Abstract: The invention pertains to methods and apparatus for performing mass spectrometry with reduced noise. In some embodiments, an additional amount of a carrier gas is introduced into a mass spectrometer to reduce the noise.

Abstract: Methods, systems and computer readable media for dynamically controlling a time period of ion detection by an ion detector of a mass spectrometer. A current resulting from conversion of an output of the detector is surveyed during the ion detection by the detector. The time period for the ion detection is terminated upon calculation of a statistically valid accumulation statistic, calculation indicating that satisfactory statistics cannot be achieved over the time period, relative to a predetermined statistical threshold, or elapsing of the entire time period having been preset.

Abstract: A system includes a vacuum manifold for a mass spectrometer. The vacuum manifold defines an orifice. A vacuum valve is joined to the manifold at the orifice. A load-lock adapter is joined to the vacuum valve. A transfer line may be introduced to the mass spectrometer and withdrawn therefrom via the vacuum valve and load-lock adapter without substantially disturbing the operating environment of the mass spectrometer.