Patents by Inventor James D. Lechleiter

James D. Lechleiter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating addiction and related disorders
    Patent number: 11839615
    Abstract: The present invention relates to adenosine receptor agonist compounds and methods of use thereof for treatment of certain disorders and conditions, for example an addiction or compulsive disorder. Exemplary compounds for use in disclosed methods include: and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: December 12, 2023
    Assignees: Astrocyte Pharmaceuticals, Inc., The Board of Regents of the University of Texas System
    Inventors: William S. Korinek, Theodore E Liston, James D. Lechleiter, Michael Beckstead
  • COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS
    Publication number: 20230165887
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Application
    Filed: September 21, 2022
    Publication date: June 1, 2023
    Inventors: William S. KORINEK, James D. LECHLEITER, Theodore E. LISTON
  • Compounds and methods for treating neurological and cardiovascular conditions
    Patent number: 11484545
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: November 1, 2022
    Assignees: Astrocyte Pharmaceuticals, Inc., The Board of Regents of the University of Texas System
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS
    Publication number: 20220305044
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Application
    Filed: April 21, 2017
    Publication date: September 29, 2022
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston, Kenneth A. Jacobson
  • HIGH CONTRAST PHOTOCONVERTIBLE FLUORESCENT PROTEINS AND METHODS OF USE
    Publication number: 20220259271
    Abstract: Disclosed herein, are photoconvertible fluorescent proteins or analogs thereof, and in particular, green-to-red photoconvertible fluorescent proteins or analogs thereof of the EosFP family; and compositions comprising the same and methods for analyzing a physiologically active substance in a cell wherein the fluorescent proteins are expressed in the cell.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 18, 2022
    Inventors: Brian J. Stoveken, James D. Lechleiter
  • COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS
    Publication number: 20220000899
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Application
    Filed: February 19, 2021
    Publication date: January 6, 2022
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • Compounds and methods for treating neurological and cardiovascular conditions
    Patent number: 10953031
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: March 23, 2021
    Assignees: Astrocyte Pharmaceuticals, Inc., The Board of Regents of the University of Texas System
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • COMPOUNDS AND METHODS FOR TREATING ADDICTION AND RELATED DISORDERS
    Publication number: 20210030760
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example an addiction or compulsive disorder.
    Type: Application
    Filed: February 8, 2019
    Publication date: February 4, 2021
    Inventors: William S. Korinek, Theodore E Liston, James D. Lechleiter, Michael Beckstead
  • COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS
    Publication number: 20200046751
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Application
    Filed: March 14, 2019
    Publication date: February 13, 2020
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • Compounds and methods for treating neurological and cardiovascular conditions
    Patent number: 10265338
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: April 23, 2019
    Assignees: ASTROCYTE PHARMACEUTICALS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • COMPOUNDS AND METHODS FOR TREATING NEUROLOGICAL AND CARDIOVASCULAR CONDITIONS
    Publication number: 20180021363
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Application
    Filed: August 7, 2017
    Publication date: January 25, 2018
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • Compounds and methods for treating neurological and cardiovascular conditions
    Patent number: 9789131
    Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: October 17, 2017
    Assignees: Astrocyte Pharmaceuticals, Inc., The Board of Regents of the University of Texas System
    Inventors: William S. Korinek, James D. Lechleiter, Theodore E. Liston
  • GPCR enhanced neuroprotection to treat brain injury
    Patent number: 8618074
    Abstract: Disclosed are methods of preventing or treating neuronal damage associated with oxidative stress and/or neuronal injury. The method comprises administering to a patient a pharmaceutical composition comprising a purinergic P2Y receptor ligand, in an amount effective to increase the extracellular concentration of said agonist in the brain of the subject such that at least a portion of cell surface P2Y receptors expressed by astrocytes are activated to mount a neuroprotective response. The pharmaceutical composition may be administered orally or parenterally. The pharmaceutical composition with typically be administered to an individual within at least one hour of the event that caused oxidative stress in the subject.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: December 31, 2013
    Assignee: Board of Regents of the University of Texas System
    Inventor: James D. Lechleiter
  • GPCR ENHANCED NEUROPROTECTION TO TREAT BRAIN INJURY
    Publication number: 20100216735
    Abstract: Disclosed are methods of preventing or treating neuronal damage associated with oxidative stress and/or neuronal injury. The method comprises administering to a patient a pharmaceutical composition comprising a purinergic P2Y receptor ligand, in an amount effective to increase the extracellular concentration of said agonist in the brain of the subject such that at least a portion of cell surface P2Y receptors expressed by astrocytes are activated to mount a neuroprotective response. The pharmaceutical composition may be administered orally or parenterally. The pharmaceutical composition with typically be administered to an individual within at least one hour of the event that caused oxidative stress in the subject.
    Type: Application
    Filed: March 17, 2008
    Publication date: August 26, 2010
    Inventor: James D. Lechleiter
  • Confocal imaging system for visible and ultraviolet light
    Patent number: 5260578
    Abstract: A scanning confocal microscope (50) capable of providing ultraviolet (UV) excitation. The optical train substantially corrects scanning and focusing errors over the wavelength range that includes UV and visible wavelengths. In a particular embodiment, the lenses (27, 30') in the common path portion of the optical train are corrected for chromatically induced scanning errors while extra lenses (60, 65) are provided in the forward UV path to correct for focusing errors due to longitudinal chromatic (visible/UV) aberration.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: November 9, 1993
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allison C. Bliton, David E. Clapham, James D. Lechleiter