Patents by Inventor James D. McChesney

James D. McChesney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5480639
    Abstract: Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of drying plant matter to preserve their taxane content and facilitate their extraction is disclosed. In addition, methods of extracting and purifying taxol and other taxanes from ornamental cultivars using a series of organic and aqueous solvents and normal phase chromatography columns are also disclosed.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: January 2, 1996
    Assignee: The University of Mississippi
    Inventors: Hala N. ElSohly, Edward M. Croom, Jr., Mahmoud A. ElSohly, James D. McChesney
  • Patent number: 5225562
    Abstract: This invention is a new method for preparing compounds useful as antimalarial agents having the formula; ##STR1## wherein R is hydrogen, a linear, branched or cyclo lower alkyl group having 1 to 8 carbon atoms; aminoalkyl; branched aminoalkyl; hydroxyalkyl: alkylcarboxylate or alkylbenzoate groups having 1 to 5 carbon atoms in the alkyl chains; aryl; alkoxy-substituted aryl; heteroaryl; and pyridinium groups. The method comprises treating artemisinic acid with a methylating agent followed by a stereoselective reduction of the methylated compound, subjecting the reduced compound to a Grignard addition followed by chiral photoxidation with subsequent treatment with a cyclization agent.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: July 6, 1993
    Inventors: James D. McChesney, Mankil Jung
  • Patent number: 5023353
    Abstract: This invention provides a new antimalarial compound, deoxoartemisinin, having the formula: ##STR1## Antimalarial compositions consisting essentially of the compound in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method for treating malaria comprising administering a therapeutically effective concentration of the compound, preferably in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method of preparing the deoxoartemisinin.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: June 11, 1991
    Inventors: James D. McChesney, Mankil Jung
  • Patent number: 4920147
    Abstract: This invention provides a new antimalarial compound, deoxoartemisinin, having the formula: ##STR1## Antimalarial compositions consisting essentially of the compound in admixture with a non-toxic, pharmaceutically-acceptable carrier. A method for treating malaria comprising administering a therapeutically effective concentration of the compound, preferably in admixture with a non-toxic, pharamceutically-acceptable carrier. A method of preparing the doxoartemisinin.
    Type: Grant
    Filed: March 28, 1989
    Date of Patent: April 24, 1990
    Inventors: James D. McChesney, Mankil Jung