Patents by Inventor James D. McCully

James D. McCully has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to chondrisomes from blood products
    Patent number: 11903975
    Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 20, 2024
    Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center Corporation
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • Methods and compositions relating to chondrisomes from cultured cells
    Patent number: 11903974
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 20, 2024
    Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center Corporation
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • THERAPEUTIC USE OF MITOCHONDRIA AND COMBINED MITOCHONDRIAL AGENTS
    Publication number: 20230416413
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Application
    Filed: September 1, 2023
    Publication date: December 28, 2023
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • PRODUCTS AND METHODS TO ISOLATE MITOCHONDRIA
    Publication number: 20230219081
    Abstract: Filtration apparatuses, kits, and methods for rapid isolation of intact, viable mitochondria from tissues are described with mitochondria isolated by differential filtration through nylon mesh filters. Mitochondria can be isolated in less than 30 minutes using the filtration apparatuses, kits, and methods described.
    Type: Application
    Filed: October 5, 2022
    Publication date: July 13, 2023
    Inventors: James D. McCully, Douglas B. Cowan, Christina A. Pacak, Sidney Levitsky
  • THERAPEUTIC USE OF MITOCHONDRIA AND COMBINED MITOCHONDRIAL AGENTS
    Publication number: 20230183380
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Application
    Filed: October 6, 2022
    Publication date: June 15, 2023
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • AEROSOLIZED COMPOSITIONS COMPRISING MITOCHONDRIA AND METHODS OF USE THEREOF
    Publication number: 20220395531
    Abstract: This disclosure pertains to pharmaceutical compositions of aerosolized compositions containing mitochondria, methods of preparing and using the compositions, and devices for administering the compositions.
    Type: Application
    Filed: April 15, 2020
    Publication date: December 15, 2022
    Inventors: James D. McCully, Pedro J. Del Nido
  • Products and methods to isolate mitochondria
    Patent number: 11491480
    Abstract: Filtration apparatuses, kits, and methods for rapid isolation of intact, viable mitochondria from tissues are described with mitochondria isolated by differential filtration through nylon mesh filters. Mitochondria can be isolated in less than 30 minutes using the filtration apparatuses, kits, and methods described.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: November 8, 2022
    Assignees: Children's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
    Inventors: James D. McCully, Douglas B. Cowan, Christina A. Pacak, Sidney Levitsky
  • PROPHYLACTIC AND THERAPEUTIC USE OF MITOCHONDRIA AND COMBINED MITOCHONDRIAL AGENTS
    Publication number: 20220347212
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating or preventing disorders or damage associated with ischemia-reperfusion injury (IRI) using such compositions.
    Type: Application
    Filed: October 30, 2019
    Publication date: November 3, 2022
    Inventors: James D. McCully, Pedro J. del Nido
  • Treating Heart Failure
    Publication number: 20220160782
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions. The described methods are based, at least in part, on the discovery that isolated mitochondria themselves, and isolated mitochondria linked to a therapeutic agent, diagnostic agent and/or imaging agent, can be delivered to a patients tissue by injecting them into the patients blood vessels.
    Type: Application
    Filed: February 14, 2020
    Publication date: May 26, 2022
    Inventor: James D. McCully
  • METHODS AND COMPOSITIONS OF CHONDRISOMES
    Publication number: 20220160784
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • Automated Isolation of Viable Mitochondria
    Publication number: 20210238534
    Abstract: An automated isolation device for isolation of mitochondria includes an incubation station including a holder for a viable mitochondria solution; and a cooling system, controlled by a processor of the device, for cooling the holder. The device includes a processor-controlled transfer system for transferring solution from the holder to a filtration station; and the filtration station, including a series of filters. The device includes a processor-controlled spectrometry station including a spectrometer positioned to illuminate a cuvette fluidically coupled to an output of the filtration station; and a detector coupled to the processor and positioned on a side of the cuvette opposite the spectrometer. The device includes a processor-controlled transfer system for transferring solution from the spectrometry station to a centrifuge. The centrifuge is processor-controlled and configured to centrifuge the filtrate to separate viable mitochondria from a supernatant.
    Type: Application
    Filed: May 8, 2019
    Publication date: August 5, 2021
    Inventors: James D. McCully, Douglas B. Cowan, Pedro J. Del Nido, Thomas Duignan
  • THERAPEUTIC USE OF MITOCHONDRIA AND COMBINED MITOCHONDRIAL AGENTS
    Publication number: 20200123273
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Application
    Filed: June 25, 2019
    Publication date: April 23, 2020
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • METHODS AND COMPOSITIONS OF CHONDRISOMES
    Publication number: 20190374582
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: January 18, 2019
    Publication date: December 12, 2019
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • Therapeutic use of mitochondria and combined mitochondrial agent
    Patent number: 10370458
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: August 6, 2019
    Assignees: Children's Medical Center Corporation and Beth Israel, Deaconess Medical Center, Inc.
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • Therapeutic Use of Mitochondria and Combined Mitochondrial Agent
    Publication number: 20180057610
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Application
    Filed: November 3, 2017
    Publication date: March 1, 2018
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • PRODUCTS AND METHODS TO ISOLATE MITOCHONDRIA
    Publication number: 20170120237
    Abstract: Filtration apparatuses, kits, and methods for rapid isolation of intact, viable mitochondria from tissues are described with mitochondria isolated by differential filtration through nylon mesh filters. Mitochondria can be isolated in less than 30 minutes using the filtration apparatuses, kits, and methods described.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Inventors: James D. McCully, Douglas B. Cowan, Christina A. Pacak, Sidney Levitsky