Abstract: A vial access transfer set for use with a bottle containing a medicinal fluid that provides a mechanism for securely attaching an administration set to the bottle and also provides a universal spike port to which any primary IV line can be readily attached. The vial access transfer set includes a novel, vented vial access adapter to which a length of tubing can be connected, the adapter comprising a top wall, a cannula connected to the top wall and a uniquely configured, resiliently deformable slitted skirt connected to the top wall and extending therefrom. With this construction, during the interconnection of the vial access transfer set with the bottle, the rubber septum of the bottle can readily be pierced by the cannula and the resiliently deformable skirt positively snapped into place over the neck portion of the drug vial or bottle to maintain the adapter in secure connection with the bottle.