Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: The present disclosure relates to aerosol delivery devices, methods of producing such devices, and elements of such devices. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in a reservoir and transported to a heating element by a liquid transport element. The liquid transport element may include a porous monolith.

Abstract: A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.

Abstract: An aerosol delivery device having a detachable power source is provided. A control body may be coupleable with a cartridge to form an aerosol delivery device. The cartridge may contain an aerosol precursor composition and be equipped with a heating element configured to activate and vaporize components of the aerosol precursor composition. The control body may comprise a housing and a power source detachably coupled to an outer surface of the housing. A control component may be contained within the housing and configured to operate in an active mode in which the control body is coupled with the cartridge. The control component in the active mode may be configured to direct power from the power source to the heating element to activate and vaporize components of the aerosol precursor composition.

Abstract: A particulate sodium bicarbonate product with an excellent flowability characterized by an angle of repose less than 30 degrees. An angle of repose of less than 27.5 is particularly good. The product is preferably in the form of ovoid or spherical particles, in that the particles have a mean axial ratio of at least 0.5. In some embodiments, the sodium bicarbonate product has a smooth particle surface in which less than 75% of the particle surface is covered with spikes. The particles may have a mean diameter D50 of at least 75 microns but less than 300 microns. The particulate sodium bicarbonate product comprises inorganic and organic impurities embedded in its polycrystalline structure, for example at least 75 ppm TOC; or at least 30 ppm Ca; or from 1 to 18 ppm Mg; or more than 0.6 g/kg NaCl; and/or from 100 to less than 500 ppm Si. A process for manufacturing such product, and its use for the treatment of pollutants in gases such as removal of acid gas.

Abstract: A solution mining method for recovering alkali values from a cavity of an underground ore formation comprising trona and/or wegscheiderite; a manufacturing process using such method to make sodium-based product(s); and a sodium-based product obtained therefrom. The method comprises: an ore dissolution phase (a) in which the incongruent double-salt in trona and/or wegscheiderite is dissolved from an ore face in a first solvent, and a cavity cleaning phase (b) in which sodium bicarbonate deposited on the ore face during the dissolution phase (a) is dissolved into a second aqueous solvent having a higher pH, hydroxide content, and/or temperature and is partly or completely converted in situ to sodium carbonate. The method further comprises withdrawing a liquor resulting from either phase to the ground surface, optionally recycling some liquor to the cavity; and passing some liquor through a crystallizer, a reactor, and/or an electrodialyser, to form at least one sodium-based product which is recovered.

Abstract: A method for removing impurities from a waste solid to provide at least a portion of a suitable crystallizer feed to a process for making crystalline sodium carbonate, bicarbonate, and/or other derivatives. The method comprises: contacting the waste solid with a leach solution to dissolve at least one impurity and dissolving the resulting leached residue. Leaching may include heap percolation. The leach solution may comprise a crystallizer purge liquor, a process waste effluent, a mine water, or mixtures thereof. The method may further comprise adding a magnesium compound to the resulting leached residue during or after its dissolution to remove another impurity. The waste solid preferably comprises a pond solid containing such impurities. The pond solid may be recovered from a pond receiving crystallizer purge liquor(s) and/or other process waste effluent(s). The pond solid may contain sodium carbonate, any hydrate thereof, sodium bicarbonate, and/or sodium sesquicarbonate.

Abstract: A particulate sodium bicarbonate product with an excellent flowability characterized by an angle of repose less than 30 degrees. An angle of repose of less than 27.5 is particularly good. The product is preferably in the form of ovoid or spherical particles, in that the particles have a mean axial ratio of at least 0.5. In some embodiments, the sodium bicarbonate product has a smooth particle surface in which less than 75% of the particle surface is covered with spikes. The particles may have a mean diameter D50 of at least 75 microns but less than 300 microns. The particulate sodium bicarbonate product comprises inorganic and organic impurities embedded in its polycrystalline structure, for example at least 75 ppm TOC; or at least 30 ppm Ca; or from 1 to 18 ppm Mg; or more than 0.6 g/kg NaCl; and/or from 100 to less than 500 ppm Si. A process for manufacturing such product, and its use for the treatment of pollutants in gases such as removal of acid gas.

Abstract: A magnesium treatment for removing water-soluble impurities in a process for making crystalline sodium carbonate, bicarbonate, or sulfite. A waste comprising such impurities is treated with a magnesium compound to form water-insoluble matter which is removed to form a purified solution. The treatment may be performed on a solution which contains the waste and optionally dissolved calcined trona. The purified solution may be used as a feedstock to form crystalline soda ash, and/or used as a reactant to produce crystalline sodium sulfite or bicarbonate via reaction with SO2 or CO2. In preferred embodiments, the waste may comprise a purge or weak liquor, a reclaimed solid, or combinations thereof. The water-soluble impurities may be silicates and/or foam-causing impurities, and the waste may contain sodium bicarbonate, sodium sesquicarbonate, and/or one or more sodium carbonate hydrates, such as decahydrate.

Abstract: A method for removing impurities from a waste solid to provide at least a portion of a suitable crystallizer feed to a process for making crystalline sodium carbonate, bicarbonate, and/or other derivatives. The method comprises: contacting the waste solid with a leach solution to dissolve at least one impurity and dissolving the resulting leached residue. Leaching may include heap percolation. The leach solution may comprise a crystallizer purge liquor, a process waste effluent, a mine water, or mixtures thereof. The method may further comprise adding a magnesium compound to the resulting leached residue during or after its dissolution to remove another impurity. The waste solid preferably comprises a pond solid containing such impurities. The pond solid may be recovered from a pond receiving crystallizer purge liquor(s) and/or other process waste effluent(s). The pond solid may contain sodium carbonate, any hydrate thereof, sodium bicarbonate, and/or sodium sesquicarbonate.

Abstract: A processing module may be provided. The processing module may include a mounting member configured to structurally support a first processing unit and receive thermal energy from the first processing unit through a coupling side of the first processing unit by conduction. The processing module may also include a base member coupled to the mounting member. The base member may be configured to receive thermal energy from the mounting member. A thermal conductivity of at least one of the mounting member and the base member may be greater than about 50 Watts/meter Celsius (W/m-C). Coefficients of thermal expansion (CTEs) of the mounting member, the base member, and the coupling side of the first processing unit may be matched.

Abstract: A magnesium treatment for removing water-soluble impurities in a process for making crystalline sodium carbonate, bicarbonate, or sulfite. A waste comprising such impurities is treated with a magnesium compound to form water-insoluble matter which is removed to form a purified solution. The treatment may be performed on a solution which contains the waste and optionally dissolved calcined trona. The purified solution may be used as a feedstock to form crystalline soda ash, and/or used as a reactant to produce crystalline sodium sulfite or bicarbonate via reaction with SO2 or CO2. In preferred embodiments, the waste may comprise a purge or weak liquor, a reclaimed solid, or combinations thereof. The water-soluble impurities may be silicates and/or foam-causing impurities, and the waste may contain sodium bicarbonate, sodium sesquicarbonate, and/or one or more sodium carbonate hydrates, such as decahydrate.

Abstract: A process for beneficiation of trona includes supplying a trona feedstream that is crushed and dried. The trona is then separated into a first size fraction and a second size fraction. Impurities are removed from the first size fraction using at least one magnetic separator. The magnetic separator includes a plurality of stages. Each stage includes a conveyer system including a first end, a second end, and a conveyer belt. Each stage also includes a magnetic roller disposed at the second end of the conveyer system and a splitter disposed adjacent the second end of the conveyer system for separating a fraction of magnetic impurities from the trona to create a beneficiated fraction. At least one conveyer belt is deionized. Airborne dust particles are removed from an area surrounding at least one conveyer system.

Abstract: The present invention provides a system and method for simulating aircraft flight path trajectory by integrating the point mass equations using a selectable non-time based integration variable, including altitude, velocity or range. The present invention separates the horizontal and vertical profiles of an aircraft's flight path trajectory. The horizontal profile is specified as a series of waypoints, defined by latitude-longitude pairs and the vertical profile is specified as an initial state and a list of segment types, defined by altitude and velocity, and end states. The altitude-velocity segment types are continuous, such that the end state of one segment is the starting point of the following segment. The point mass equations and the non-time based integration variables are iteratively integrated to merge the horizontal and vertical profiles of a flight path trajectory.

Abstract: A process for the beneficiation of trona includes supplying a trona feedstream that is crushed and dried. The trona is then separated into a first size fraction and a second size fraction. Impurities are removed from the first size fraction using at least one magnetic separator. The magnetic separator includes a plurality of stages. Each stage includes a conveyor system comprising a first end, a second end, and a conveyor belt. Each stage also includes a magnetic roller disposed at the second end of the conveyor system and a splitter disposed adjacent the second end of the system for separating a fraction of magnetic impurities from the trona to create a beneficiated fraction. At least one conveyor belt is deionized. Airborne dust particles are removed from an area surrounding at least one conveyor system.

Abstract: A process for beneficiation of trona includes supplying a trona feedstream that is crushed and dried. The trona is then separated into a first size fraction and a second size fraction. Impurities are removed from the first size fraction using at least one magnetic separator. The magnetic separator includes a plurality of stages. Each stage includes a conveyer system including a first end, a second end, and a conveyer belt. Each stage also includes a magnetic roller disposed at the second end of the conveyer system and a splitter disposed adjacent the second end of the conveyer system for separating a fraction of magnetic impurities from the trona to create a beneficiated fraction. At least one conveyer belt is deionized. Airborne dust particles are removed from an area surrounding at least one conveyer system.

Abstract: A method and apparatus for bending a plastic tube using heated dies. The tube is cooled after release from the dies and takes a set. A spring may be inserted in the tube to support the tube while it is being bent.

Abstract: A process for recovery of alkali values from trona in which trona is dissolved, the sodium carbonate in the feed solution is converted to sodium bicarbonate by introducing carbon dioxide, sodium bicarbonate is crystallized and separated from a mother liquor, and sodium bicarbonate in the mother liquor is converted to sodium carbonate by introducing air to form a recirculating dissolving solution which is used to dissolve the trona.

Abstract: A preferred embodiment of FIGS. 1-3 includes a check valve (10) with a pair of semicircular check valve members (34, 36) normally permitting fluid flow in one direction and blocking fluid flow in an opposite direction. Semicircular valve member (36) is releasably locked in an open position to permit a back flow upon manual rotation of handle (46) after manual gripping of knurled knob (84) and withdrawal of a locking pin (82) from a receiving opening (96). A safety lever (98) is pivoted out of a covering relation to knob (84) before knob (84) is gripped and prevents rotation of shaft (38) unless lever (98) is manually pivoted out of covering relation with knob (84). Another embodiment shown in FIG. 4 permits selective opening of a semicircular plate valve member (34A or 36A) to a releasably locked open position. Manual rotation of handle (46A) in one direction effects movement of semicircular valve member (36A) to an open position.

Abstract: This invention provides a method for the production of dense soda ash by reacting sodium carbonate decahydrate with a light soda ash or soda ash fines at an elevated temperature to produce sodium carbonate monohydrate crystals, and drying the sodium carbonate monohydrate to produce dense soda ash.