Abstract: The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting a solute carrier family member gene, e.g., SLC30A10, or SLC39A8. The invention also relates to methods of using such RNAi agents to inhibit expression of a solute carrier family member gene, e.g., an SLC30A10 gene, or an SLC39A8 gene, and to methods of preventing and treating a solute carrier family member-associated disorder, e.g., a hypermanganesemia.

Abstract: A handgrip for placement about an elongated member is disclosed. The handgrip includes a resilient body member having an arcuate gripping surface adapted to conform to the outer surface of the elongated member. A plurality of outwardly extending curvilinear projections are adapted to conform to the shape of a hand of a user. A finger engaging member extends from the resilient body member. The finger engaging member is adapted to retain the handgrip on the hand of a user after the elongated member is released.

Abstract: An exhaust sensor comprises a sensing electrode and a reference electrode each in contact with an electrolyte. At least one of the sensing electrode and the reference electrode are formed by depositing an electrode precursor material on an electrolyte precursor material and sintering the combination at a sufficient temperature for a sufficient time to achieve densification of the electrolyte, wherein the electrode precursor material comprises an alkali salt. Electrode patterns having enhanced perimeter ratios are also disclosed. The resulting exhaust sensor is capable of providing a usable output at a reduced operating temperature.

Abstract: A wire retention clip includes a first compartment for allowing at least a first wire to pass through the compartment uninterrupted and for retaining the at least one wire to the wire retention clip. The wire retention clip also includes a second compartment that is distinct from the first compartment and contains and electronic device.

Abstract: A wire retention clip includes a first compartment for allowing at least a first wire to pass through the compartment uninterrupted and for retaining the at least one wire to the wire retention clip. The wire retention clip also includes a second compartment that is distinct from the first compartment and contains and electronic device.

Abstract: An exhaust sensor comprises a sensing electrode and a reference electrode each in contact with an electrolyte. At least one of the sensing electrode and the reference electrode are formed by depositing an electrode precursor material on an electrolyte precursor material and sintering the combination at a sufficient temperature for a sufficient time to achieve densification of the electrolyte, wherein the electrode precursor material comprises an alkali salt. Electrode patterns having enhanced perimeter ratios are also disclosed. The resulting exhaust sensor is capable of providing a usable output at a reduced operating temperature.

Abstract: An improved method of diagnosing shaft sensor failure in a reciprocating internal combustion engine verifies engine rotation by sensor information responsive to dynamic variation in engine air intake that occurs during engine rotation. Failure of the shaft sensor is diagnosed when the dynamic variation in engine air intake is detected in the absence of a shaft sensor signal. The sensor information used to detect the dynamic variation in intake air may be obtained from either a mass air flow sensor disposed in a throttle passage of the engine, or from a pressure sensor disposed in an intake manifold of the engine, and virtually all current engine control systems utilize at least one of these sensors. The dynamic variation is detected by recognizing rising and falling segments of the signal waveform, by comparing the relative manifold pressure to predetermined maximum and minimum values, or by using a derivative of the signal waveform to recognize its inflection points.

Abstract: An improved method of diagnosing shaft sensor failure in a reciprocating internal combustion engine verifies engine rotation by sensor information responsive to dynamic variation in engine air intake that occurs during engine rotation. Failure of the shaft sensor is diagnosed when the dynamic variation in engine air intake is detected in the absence of a shaft sensor signal. The sensor information used to detect the dynamic variation in intake air may be obtained from either a mass air flow sensor disposed in a throttle passage of the engine, or from a pressure sensor disposed in an intake manifold of the engine, and virtually all current engine control systems utilize at least one of these sensors. The dynamic variation is detected by recognizing rising and falling segments of the signal waveform, by comparing the relative manifold pressure to predetermined maximum and minimum values, or by using a derivative of the signal waveform to recognize its inflection points.

Abstract: A detachable grip for placement about an elongated member is disclosed. The grip includes a resilient body member having an arcuate gripping surface adapted to conform to the outer surface of the elongated member. A plurality of outwardly extending curvilinear projections are adapted to conform to the shape of a hand of a user. First and second pairs of resilient securing members extend from the body member. Attachment means releasably attach distal ends of each pair of securing members to each other in an overlapping relationship around the elongated member.

Abstract: An improved butterfly valve having leak detecting means, the valve body having a flow passageway therethrough, and co-axial top and bottom shaft openings and a seat circumscribing the flow passageway, a disc having an uninterrupted circumferential sealing surface having two spaced apart circumferential sealing contacts providing a circumferential valley therebetween. An upper and lower shaft portion is received in the body shaft openings, one of the shaft portions being secured to the disc providing means of positioning the disc and one of the shaft portions having a passageway therein communicating with the exterior of the valve body, the disc having a passageway communicating with the disc circumferential valley and the shaft passageway so that fluid leakage past either one of the disc sealing contacts will be conducted exteriorly of the body as an indication of loss of valve integrity when the valve is in the closed position.