Abstract: The present invention relates to compositions and methods for the detection and characterization of interfering RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs) and other short nucleic acid molecules. More particularly, the present invention relates to improved methods for the detection and quantitation of interfering RNA expression. The present invention further provides for the detection of variants and types of miRNAs and siRNAs.

Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).

Abstract: A direct memory access (DMA) controller having a first mode and a second mode controls communication between a module bus, communicating with a processor and a memory, and an input/output (I/O) bus communicating with an external device. A data controller subsystem stores I/O bus input data to provide module bus output data, and stores module bus input data to provide I/O bus output data. A device address controller subsystem stores a device address from the module bus to provide an I/O device output address to the I/O bus for addressing the external device. A memory addressing subsystem receives module bus input data to form an initial memory address provided to the module bus representing a storage location in the memory. An incrementer increments the initial memory address.

Abstract: A priority selector prioritizes interrupts associated with each ASIC of a plural ASIC system in accordance with a programmed sequence. A table in each ASIC contains a programmable offset table and a programmable priority code table. The table selects an offset value and a priority code associated with the highest priority interrupt for the ASIC. An interrupt collector includes a priority compare to identify the priority code of the highest-priority interrupt of all of the ASICs. A multiplexer selects the offset value associated with it. The offset value forms a jump or offset address to the interrupt for the CPU. The priority sequencing, offset tables, priority code tables and priority compare values are programmable, so the prioritizing is adjustable. Each priority selector generates an interrupt active signal for the CPU. A mask disables interrupts until serviced by the CPU so that any interrupt active signal resulting from a disabled interrupt is terminated.

Abstract: A top state controller controls a bus adapter to a selected master or slave top state in response to a command on a local or system bus during a dispatch state of the bus adapter. The bus adapter remains in the selected top state until the command is completed or suspended, whereupon it returns to the dispatch state. The top state controller sets a first flag upon a change from a master top state to the dispatch state in response to suspension of a command by a data handling device, and sets a second flag upon a change from a slave top state to the dispatch state upon completion of a command. The top state controller is responsive to the first or second flag to operate the bus adapter to that master top state from which the bus adapter changed to set the first flag and is responsive to the completion of the suspended command to clear the first and said second flags.