Abstract: An optical waveguide having a cladding layer formed of high-purity glass, or a cladding layer formed of high-purity isotope-proportion modified glass, and with a core of high-purity isotope-proportion-modified glass with the index of refraction of the core glass greater than the index of refraction of the cladding glass, said high-purity isotope-proportion-modified core material having a Si-29-isotope proportion at most 4.447% Si-29 (atom/atom) of all silicon atoms in said core, or at least 4.90% of Si-29 (atom/atom) atoms in said core, or having a Ge-73 isotope proportion of at most 7.2% Ge-73 (atom/atom) of all germanium atoms in said core, or at least 8.18% of Ge-73 (atom/atom) of Germanium atoms in said core region.

Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

Abstract: A method of monitoring media playback includes outputting media content from a server over a network to a client device, and receiving at the server from the client device, a plurality of beacon signals, each beacon signal having at least one pair of timing data items. A first data item in the pair represents a point in time in the media content and a second data item in the pair represents a time indicated by a real time clock of the client device at which time the part of media content corresponding to the point in time was being played by the client device. The at least one of processed or stored beacon signals are at the server so as to monitor the playback of the media content by the client device.

Abstract: An optical waveguide having a cladding layer formed of high-purity glass, or a cladding layer formed of high-purity isotope-proportion modified glass, and with a core of high-purity isotope-proportion-modified glass with the index of refraction of the core glass greater than the index of refraction of the cladding glass, said high-purity isotope-proportion-modified core material having a Si-29-isotope proportion at most 4.447% Si-29 (atom/atom) of all silicon atoms in said core, or at least 4.90% of Si-29 (atom/atom) atoms in said core, or having a Ge-73 isotope proportion of at most 7.2% Ge-73 (atom/atom) of all germanium atoms in said core, or at least 8.18% of Ge-73 (atom/atom) of Germanium atoms in said core region.

Abstract: The present disclosure provides for systems, devices, and methods which address needs of seniors, disabled persons, or any other similar users, at a stage in life when they can still live independently while benefiting from monitored care. Embodiments described herein enable a higher level of connectivity without requiring the member to be technologically savvy, and provides a simple mechanism for personalized emergency support. Embodiments utilize at least one personal communication device which may allow for remote interactions with medical and concierge personnel in a monitoring center or other emergency contacts, in order to fulfill requests for everyday needs, ranging from providing directions to a locations, to health alerts based on health and status measurements collected electronically and remotely.

Abstract: The present disclosure provides for systems, devices, and methods which address needs of seniors, disabled persons, or any other similar users, at a stage in life when they can still live independently while benefiting from monitored care. Embodiments described herein enable a higher level of connectivity without requiring the member to be technologically savvy, and provides a simple mechanism for personalized emergency support. Embodiments utilize at least one personal communication device which may allow for remote interactions with medical and concierge personnel in a monitoring center or other emergency contacts, in order to fulfill requests for everyday needs, ranging from providing directions to a locations, to health alerts based on health and status measurements collected electronically and remotely.

Abstract: An implantable connector includes: first and second detachable mating parts configured to be implantable in living tissue, to terminate first and second segments of a cable, and have first and second interfacing surfaces, respectively; and a protection structure configured to protect against contaminant intrusion between the first and second interfacing surfaces. And a device for decoupling and re-coupling the detachable mating parts in an environmentally controllable volume is provided.

Abstract: An optical waveguide having a cladding layer formed of high-purity glass, or a cladding layer formed of high-purity isotope-proportion modified glass, and with a core of high-purity isotope-proportion-modified glass with the index of refraction of the core glass greater than the index of refraction of the cladding glass, said high-purity isotope-proportion-modified core material having a Si-29-isotope proportion at most 4.447% Si-29 (atom/atom) of all silicon atoms in said core, or at least 4.90% of Si-29 (atom/atom) atoms in said core, or having a Ge-73 isotope proportion of at most 7.2% Ge-73 (atom/atom) of all germanium atoms in said core, or at least 8.18% of Ge-73 (atom/atom) of Germanium atoms in said core region.

Abstract: The present disclosure provides for systems, devices, and methods which address needs of seniors, disabled persons, or any other similar users, at a stage in life when they can still live independently while benefiting from monitored care. Embodiments described herein enable a higher level of connectivity without requiring the member to be technologically savvy, and provides a simple mechanism for personalized emergency support. Embodiments utilize at least one personal communication device which may allow for remote interactions with medical and concierge personnel in a monitoring center or other emergency contacts, in order to fulfill requests for everyday needs, ranging from providing directions to a locations, to health alerts based on health and status measurements collected electronically and remotely.

Abstract: An optical waveguide having a cladding layer formed of high-purity glass, or a cladding layer formed of high-purity isotope-proportion modified glass, and with a core of high-purity isotope-proportion-modified glass with the index of refraction of the core glass greater than the index of refraction of the cladding glass, said high-purity isotope-proportion-modified core material having a Si-29-isotope proportion at most 4.447% Si-29 (atom/atom) of all silicon atoms in said core, or at least 4.90% of Si-29 (atom/atom) atoms in said core, or having a Ge-73 isotope proportion of at most 7.2% Ge-73 (atom/atom) of all germanium atoms in said core, or at least 8.18% of Ge-73 (atom/atom) of Germanium atoms in said core region.

Abstract: An optical waveguide having a cladding layer formed of high-purity glass, or a cladding layer formed of high-purity isotope-proportion modified glass, and with a core of high-purity isotope-proportion-modified glass with the index of refraction of the core glass greater than the index of refraction of the cladding glass, said high-purity isotope-proportion-modified core material having a Si-29-isotope proportion at most 4.447% Si-29 (atom/atom) of all silicon atoms in said core, or at least 4.90% of Si-29 (atom/atom) atoms in said core, or having a Ge-73 isotope proportion of at most 7.2% Ge-73 (atom/atom) of all germanium atoms in said core, or at least 8.18% of Ge-73 (atom/atom) of Germanium atoms in said core region.

Abstract: A system for cleaning mating parts of an implantable connector includes an implantable connector and a cleaning structure. The implantable connector includes first and second detachable mating parts configured: to be implantable in living tissue; to terminate at least a first segment of a cable; and to have with first and second interfacing surfaces, respectively. The clean structure includes: a cleaning structure configured to clean the first and second interfacing surfaces as the first and second mating parts are being engaged.

Abstract: An implantable connector includes: first and second detachable mating parts configured to be implantable in living tissue, to terminate first and second segments of a cable, and have first and second interfacing surfaces, respectively; and a protection structure configured to protect against contaminant intrusion between the first and second interfacing surfaces. And a device for decoupling and re-coupling the detachable mating parts in an environmentally controllable volume is provided.

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract: A dosing regimen comprising a therapeutically effective amount of flavopiridol or a pharmaceutically acceptable salt thereof optionally in combination with a pharmaceutically acceptable carrier suitable for bolus infusion and subsequently for infusion is disclosed and claimed. Also disclosed and claimed is a method of treating a variety of cancers in a patient comprising administering to said patient the dosing regimen of the invention.

Abstract: A personal care cleansing composition having enhanced perceptible skin benefits, for example, by selecting certain ratios of quaternary ammonium compounds and free fatty acids. Additionally, in accordance with various aspects of the present invention, the present inventors have discovered that the addition of talc in varying percentages increases qualities to the user such as freshness, smoothness, lather and creaminess. Additionally, aspects relating to fragrance retention, deposition and the amounts perceived are improved.

Abstract: A prosthetic hearing device comprising a biocompatible housing having a surface that vibrates in response to sound waves traveling through tissue; and an interferometer mounted in the housing, the interferometer is constructed and arranged to generate a light beam that impinges on a reflective interior surface of the vibrating surface, and to receive light reflected from the reflective interior surface. The device detects ambient sound by impinging a light beam on a portion of the vibrating surface; receiving light reflected from the reflective portion; measuring the movement of the vibrating surface based on an interference pattern of the impinging and reflected light; and determining at least a frequency of the incident sound wave based on the interference pattern.

Abstract: A virtual wire assembly that includes a substantially electrically-nonconductive substrate and a plurality of hermetic feedthroughs including a conductive region extending transversely through the substrate to form a conductive pathway with accessible surfaces at opposing ends thereof, wherein each conductive pathway is electrically isolated from other conductive pathways. In certain embodiments of this aspect of the invention, the substantially electrically-nonconductive substrate is a semiconductor device, and the conductive regions each include an n-type or a p-type doped semiconductor material.

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.