Abstract: The present invention relates to novel lipidated peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts, solvates and/or other forms thereof, corresponding pharmaceutical compositions, methods and/or uses of the IL-23R inhibitors for treatment of autoimmune inflammation diseases and/or related disorders.

Abstract: The present invention relates to novel lipidated peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts, solvates and/or other forms thereof, corresponding pharmaceutical compositions, methods and/or uses of the IL-23R inhibitors for treatment of autoimmune inflammation diseases and/or related disorders.

Abstract: The present invention relates to novel cyclic peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders. The inhibitor of an interleukin-23 receptor is cyclized by a disulfide bond between penicillamine, cysteine, homocysteine, or alpha methylcysteine residues at positions X4 and X9.

Abstract: A web-based service that provides a range of sexual education experiences, ranging from unobjectionable to pornographic, all may be moderated by the same worker is disclosed. In the unobjectionable to pornographic segments of training, various products will be discussed and used. These products may be purchased by clicking through a link on the video training page and being taken to a product page which is constructed to match the training page in its explicitness, i.e., unobjectionable to pornographic. An alternative embodiment of the present invention features a product page which is constructed to not match the training page in its explicitness, i.e., unobjectionable to pornographic.

Abstract: The present invention relates to novel lipidated peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts, solvates and/or other forms thereof, corresponding pharmaceutical compositions, methods and/or uses of the IL-23R inhibitors for treatment of autoimmune inflammation diseases and/or related disorders.

Abstract: An internal lining system of an industrial chimney includes a first building block and a second building block, each having a front face facing gas flowing through the industrial chimney; a joint of binding material configured to connect the first and second building blocks such that the front faces of the first and second building blocks are aligned; and a slot formed on the front face of the first building block, smoothly crossing the joint of binding material, and formed on the front face of the second building block; wherein the slot has a depth smaller than depths of the first and second building blocks.

Abstract: This invention discloses methods and apparatus for providing an ophthalmic lens with diffractive/refractive variable optic structures. An energy source is capable of powering the variable optic included within the ophthalmic lens as it may be predetermined. In some embodiments, an ophthalmic lens is cast molded from a silicone hydrogel.

Abstract: A Compton imager and method are provided for generating three-dimensional images. The Compton imager detects Compton scattering of simultaneously or nearly simultaneously emitted gamma rays produced by a radio-nuclide. A possible location of each radio-nuclide decay is defined by the intersection of Compton direction cones corresponding to the detected gamma rays. Three-dimensional images are generated by superposition of individual locations of separate radioactive decay locations.