Abstract: A device for sampling fluid from a subject includes a body having a fluid inflow end and a fluid outflow end, and a needle adapted to penetrate the subject to sample fluid. The needle is in fluid communication with the body at the fluid inflow end. The body has a body portion at the fluid outflow end that is couplable with a collecting receptacle. The coupling is such that an interior of the collecting receptacle remains in fluid communication with the ambient environment to permit the fluid to be passively collected into the collecting receptacle during fluid sampling. A method for sampling fluid from a subject with a sampling device is provided. A collecting receptacle releasably couplable with a device for sampling fluid from a subject is also provided. A kit including a sampling device and one or more collecting receptacles is also provided.

Abstract: A hand-operable surgical clip applicator (10) including a barrel (12) having a first end (14) and a second end (16), the second end formed to accommodate a surgical clip, a crimping lever (20) pivotally connected at the second end of the barrel, and a trigger (28) co-located with the barrel, the trigger being operable to pivot the crimping lever, the pivoting movement of the crimping lever causing the surgical clip to be urged from an open position to a closed position, wherein the trigger has an operating portion on either side of the barrel.

Abstract: A hand-operable surgical clip applicator (10) including a barrel (12) having a first end (14) and a second end (16), the second end formed to accommodate a surgical clip, a crimping lever (20) pivotally connected at the second end of the barrel, and a trigger (28) co-located with the barrel, the trigger being operable to pivot the crimping lever, the pivoting movement of the crimping lever causing the surgical clip to be urged from an open position to a closed position, wherein the trigger has an operating portion on either side of the barrel.

Abstract: The disclosure relates to a medical dispenser, comprising an outlet and a plurality of sealed compartments containing medicament to be sequentially aligned with and dispensed through said outlet. Movement of an actuator sequentially causes mechanical energy to be built up and then released and converted into an indexing movement of the compartments. The disclosure also relates to an indexing method for a medical dispenser.

Abstract: A hand-operable surgical clip applicator (10) including a barrel (12) having a first end (14) and a second end (16), the second end formed to accommodate a surgical clip, a crimping lever (20) pivotally connected at the second end of the barrel, and a trigger (28) co-located with the barrel, the trigger being operable to pivot the crimping lever, the pivoting movement of the crimping lever causing the surgical clip to be urged from an open position to a closed position, wherein the trigger has an operating portion on either side of the barrel.

Abstract: An inhaler, including a base having at least one air-tight, foil-sealed cavity containing medicament is disclosed. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. A method of dispensing a medicament from a sealed cavity inside an inhaler is also disclosed.

Abstract: A dry powder inhaler comprises a disc-shaped assembly (14) having cavities (16) filled with medicament powder for inhalation. The assembly is rotatably mounted in a housing (6, 8) on which is mounted a rotatable external casing (11, 12). A mouthpiece (10) is movably mounted on the housing (6, 8) allowing it to be brought into and out of engagement with the edge of the disc (14) whereby the mouthpiece acts as a brake to prevent or permit rotational movement of the disc (14). The inhaler is opened by rotating the housing with respect to the casing (11, 12) to expose the mouthpiece (10). As the inhaler is opened and closed, cam followers (105) on the mouthpiece move along cam tracks (109) in the casing (11, 12), causing the mouthpiece to move against or away from the disc (14). A gap is defined between the disc and mouthpiece to allow a flow of bypass air to enter the mouthpiece.

Abstract: A dry powder inhaler (2) comprises a housing (6, 8) including a mouthpiece (10) and a cover (11, 12) movably mounted to the housing (6, 8). The cover (11, 12) is movable between an open configuration of the inhaler (2) in which the mouthpiece (10) is exposed for use and a closed configuration of the inhaler (2) in which the mouthpiece (10) is enclosed. In the open position, the cover (11, 12) at least partly defines an inlet aperture (71) to an inhalation air flow path leading through the inhaler (2) and communicating with the mouthpiece (10). The inlet aperture (71) is positioned in such a way that makes it difficult for a user to obstruct it when using the inhaler (2). Preferably, in the closed position, the mouthpiece (10) is received into the inlet aperture (71) to protect the mouthpiece (10) when the inhaler (2) is stored.

Abstract: The present invention relates to an inhaler, comprising a base having at least one air-tight, foil-sealed cavity containing medicament. An actuator is engagable with a separating element attached to the foil, the actuator having an energized position in which it is biased towards an unloaded position so as to cause the separating element and attached foil to be moved away from the cavity. A latch has a first position, in which it latches the actuator in said energized position, wherein the latch is at least partly arranged in a flow path such that an inhalation flow through the flow path affects the latch to move from the first position to the second position. The invention also relates to a method of dispensing a medicament from a sealed cavity inside an inhaler.

Abstract: A hand-operable surgical clip applicator (10) including a barrel (12) having a first end (14) and a second end (16), the second end formed to accommodate a surgical clip, a crimping lever (20) pivotally connected at the second end of the barrel, and a trigger (28) co-located with the barrel, the trigger being operable to pivot the crimping lever, the pivoting movement of the crimping lever causing the surgical clip to be urged from an open position to a closed position, wherein the trigger has an operating portion on either side of the barrel.

Abstract: The disclosure relates to a medical dispenser, comprising an outlet and a plurality of sealed compartments containing medicament to be sequentially aligned with and dispensed through said outlet. Movement of an actuator sequentially causes mechanical energy to be built up and then released and converted into an indexing movement of the compartments. The disclosure also relates to an indexing method for a medical dispenser.

Abstract: The disclosure relates to an inhaler comprising an outlet through which doses of medicament may be dispensed. The inhaler also comprises a dispensing mechanism having a primed state, in which it is ready for dispensing a dose, and a fired state, in which it has dispensed a dose. In one aspect, the inhaler also comprises a disabler which, after the final dose has been dispensed, is activated to disable the dispensing mechanism from generating a sound which has been audible when the dispensing mechanism has moved from its primed state to its fired state. In a second aspect, the disabler prevents the dispensing mechanism from being in its primed state when an outlet cover is in an open position, whereby a not ready indication is presented to the user.