Abstract: Methods and apparatus to form biocompatible energization elements are described. In some examples, the methods and apparatus to form the biocompatible energization elements involve forming pellets comprising active cathode chemistry. The active elements of the cathode and anode are sealed with a biocompatible material. In some examples, a field of use for the methods and apparatus may include any biocompatible device or product that requires energization elements.

Abstract: An extensible single point orchestration system receives service requests from applications. In dependence upon the service request a single third party provider service or multiple third party provider services is identified. When the single third party provider service is identified, the system dynamically adapts a core capability service, using a stored configuration entity, so as to set an appropriate message format and transmit a service call message to an external API of the identified single third party provider service. When multiple third party provider services are identified, the system dynamically adapts the core capability service, using another stored configuration entity, so as to set a respective appropriate message format for parallel data transmission of service call messages to each of the respective identified third party provider services and transmits the service call messages to respective external APIs of each of the third party provider services.

Abstract: Designs, strategies and methods to form energization elements comprising polymer electrolytes are described. In some examples, the biocompatible energization elements may be used in a biomedical device. In some further examples, the biocompatible energization elements may be used in a contact lens.

Abstract: Anode formulations and designs for use in biocompatible energization elements are described. In some examples, a field of use for the apparatus may include any biocompatible device or product that requires energization elements.

Abstract: A microfluidic cartridge and a microfluidic delivery device having a housing and a microfluidic cartridge releasably connectable with the housing are provided. The microfluidic cartridge includes a reservoir for containing a fluid composition, a first face, and a second face joined with the first face. The electrical circuit has a first end portion and a second end portion. The first end portion of the electrical circuit is disposed on the first face and the second end portion of the electrical circuit is disposed on the second face. The first end portion includes electrical contacts and one or more circuit minor openings that are configured to mate with minor guideposts on the housing of a microfluidic delivery device. The microfluidic cartridge may include one or more major openings that are configured to mate with major guideposts on the housing. The microfluidic cartridge includes a microfluidic die disposed on the second face.

Abstract: Thinned, flexible surface regions upon which flexible active components may be utilized to attach flexible active components in space/volume constrained devices, for example, a powered ophthalmic device. Thinned, flexible surface regions foster an avenue for enhanced functionality because various electronic circuits and components can be integrated into polymeric structures.

Abstract: A converged Operations Support System (OSS) for managing a hierarchical network environment including a plurality of network domains. In one embodiment, each OSS component of the OSS is mapped against a particular hierarchical information layer of a plurality of hierarchical information layers required to manage the hierarchical network environment. When a query is received at a northbound interface of the OSS from an external requester, a determination is made as to which particular hierarchical information layers are required to generate a response to the query. Responsive to the determination, the query may be forwarded to one or more OSS components mapped to the particular hierarchical information layers for generating a response.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: A system includes a first body of a fluid-handling component and a second body of a fluid-handling component. The system also includes a fastener configured to couple the first body to the second body, and an annular sleeve configured to surround a portion of the fastener that is positioned at an interface between the first body and the second body when the first body and the second body are coupled to one another.

Abstract: A microfluidic cartridge is provided. The microfluidic cartridge has a reservoir configured to contain a fluid composition. The microfluidic cartridge has a first face and a second face joined with the first face along a first edge. The second face comprises a second face outermost point in an X-direction. The microfluidic cartridge has a third face opposing the first face in a Z-axis and joined with the second face along a second edge. The microfluidic cartridge includes an electrical circuit having a first end portion disposed on the first face and a second end portion disposed on the second face. The microfluidic cartridge has a microfluidic die in electrical communication with the electrical circuit and in fluid communication with the reservoir. The microfluidic die is disposed on a region of the second face that is positioned inward from the second face outermost point in the X-direction.

Abstract: A portable storage device that includes a storage body comprising a plurality of sides enclosing a space suitable for storing items therein, and a wheel assembly coupled to the storage body suitable for enabling transportation of the portable storage device over a surface. The wheel assembly includes one or more wheels that can be pivoted around axle assemblies. During storage or use of the portable storage device, the wheels may be pivoted inward to a storage position. When the user is ready to move or transport the portable storage device on its wheels, the wheels may be pivoted outward.

Abstract: A user-activity video signal can be received. The user-activity video signal can comprise a video capture characterizing a user's interaction with a software application on a client. The software application can have an interface display space on the client and the software application can execute on the client in operation with at least one remote backend computing system. Backend user interaction data corresponding to the user's interaction with the software application as generated by the at least one remote backend computing system can be received. A new video comprising a plurality of divided segments of the user-activity video signal can be generated automatically using the backend user interaction data and a plurality of predefined rules. The new video can be provided. Related apparatus, systems, techniques, and articles are also described.

Abstract: A microfluidic cartridge is provided. The microfluidic cartridge is configured to be releasably connectable with a microfluidic delivery device. The microfluidic cartridge has a reservoir configured to contain a fluid composition. The microfluidic cartridge has a first face with a first opening and a second opening. The microfluidic cartridge also includes a second face joined with the first face, a third face joined with the second face and opposing the first face, and a fourth face joined with the third face and the first face and opposing the second face. The fourth face has a connector. The microfluidic cartridge has an electrical circuit with a first end portion disposed on the first face and a second end portion disposed on the second face. The microfluidic cartridge also includes a microfluidic die disposed on the second face. The microfluidic die is in electrical communication with the electrical circuit and in fluid communication with the reservoir.

Abstract: Methods to form a device whereon flexible component elements are attached upon three-dimensional surfaces are described. In some aspects, the present invention includes incorporating flexible semiconductor devices onto three-dimensional surfaces with electrical contacts. In some aspects, the formed device may be incorporated in an ophthalmic device.

Abstract: A system for tracking a count of a product in a distribution unit is provided. The distribution unit may have a front portion where the product is presented for dispensing. The system may include a track, a product positioner, a sensor, and a processor. The track may be configured for holding the product in the distribution unit. The product positioner may interact with the track for pushing the product to the front of the distribution unit. The sensor may determine a position of the product positioner. The processor may calculate a product count in response to the position.

Abstract: A device for sampling fluid from a subject includes a body having a fluid inflow end and a fluid outflow end, and a needle adapted to penetrate the subject to sample fluid. The needle is in fluid communication with the body at the fluid inflow end. The body has a body portion at the fluid outflow end that is couplable with a collecting receptacle. The coupling is such that an interior of the collecting receptacle remains in fluid communication with the ambient environment to permit the fluid to be passively collected into the collecting receptacle during fluid sampling. A method for sampling fluid from a subject with a sampling device is provided. A collecting receptacle releasably couplable with a device for sampling fluid from a subject is also provided. A kit including a sampling device and one or more collecting receptacles is also provided.

Abstract: Methods and apparatus for sealing and encapsulating components on and within a multi-piece insert are set forth herein. In some embodiments, an ophthalmic lens is cast molded from a silicone hydrogel and the component includes a sealed and encapsulated multi-piece insert portion.

Abstract: This disclosure relates to a system and method for detecting structural integrity of a well casing. The system may detect casing structural integrity events. The casing structural integrity events may include structural failures of the casing and/or potential structural failures of the casing. The well casing may be drilled and/or otherwise embedded into a geologic structure. The well casing may be subject to geologic forces generated by the geologic structure. Unplanned and/or unexpected forces and/or movement may pose a risk to the structural integrity of the casing. Forces and/or movement of sufficient magnitude may result in damage to and/or destruction of the casing. Damage to and/or destruction of the casing may cause a loss of the natural resources being extracted via the well associated with the well casing, contamination of areas surrounding the well, undesirable surface expression, and/or other negative effects.