Patents by Inventor James Darnell

James Darnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240054855
    Abstract: An automated system for lottery application is provided which allows the players to choose the best options based on past statistic and other methods. The system displays the underdogs, stars and provides various other novel features which are innovative in nature.
    Type: Application
    Filed: August 14, 2022
    Publication date: February 15, 2024
    Inventor: James Darnell Mills, JR.
  • Patent number: 8723008
    Abstract: A snare drum kick stand having a base having at least one slot, with a front cradle is supported by front uprights fixably attached to the base, and a rear cradle supported by rear uprights attached to a rear cross bar; attached to the rear cross bar is at least one releasable fastener that slidably attaches to the at least one slot in the base; the front cradle has attached to it an end stop with at least one nub suitable for engaging the rim of a snare drum, and the rear cradle has a rear end stop; fixably attached to the base is a spur mounting plate and at least one spur is adjustably attached to the mounting plate with at least one spur fastener.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: May 13, 2014
    Inventor: Dean James Darnell
  • Publication number: 20060160152
    Abstract: The present invention describes methods of producing milligram quantities of three forms of purified Stat1 protein from recombinant DNA constructs. In addition, the Stat proteins may be isolated in their phosphorylated or nonphosphorylated forms (Tyr 701). The proteins can be produced in baculovirus infected insect cells, or E. coli. A compact domain in the amino terminus of Stat1? was isolated and found to enhance DNA binding due to its ability to interact with a neighboring Stat protein. A relatively protease-resistant recombinant truncated form of the Stat protein was isolated in 40-50 mg quantities. Purification of the Stat proteins were performed after modifying specific cysteine residues of the Stat proteins to prevent aggregation. Activated EGF-receptor partially purified from membranes by immunoprecipitation was shown to be capable of in vitro catalysis of the phosphorylation of the tyrosine residue of Stat1 known to be phosphorylated in vivo.
    Type: Application
    Filed: January 19, 2006
    Publication date: July 20, 2006
    Inventors: Uwe Vinkemeier, James Darnell
  • Publication number: 20060020112
    Abstract: The present invention relates to methods for identifying interacting regions of transcription factors, and methods for identifying agents which modulate the interactions, useful for affecting gene regulation, for example, cellular transformation. A site within residues 130-154 and within residues 343-358 in Stat3 were found to interact with the transcription factor c-Jun. On c-Jun, a site within residues 105 and 334, and more particularly, between 105 and 263, interact with Stat3. These sites of interactions permit methods for identifying agents which modulate the interaction between these transcription factors to modulate gene transcription.
    Type: Application
    Filed: September 1, 2005
    Publication date: January 26, 2006
    Inventors: Xiaokui Zhang, Curt Horvath, Melissa Wrzeszczynska, James Darnell
  • Publication number: 20050079543
    Abstract: Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN? and IFN?. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested.
    Type: Application
    Filed: August 12, 2003
    Publication date: April 14, 2005
    Inventors: James Darnell, Christian Schindler, Xin-Yuan Fu, Zilong Wen, Zhong Zhong
  • Patent number: 4834000
    Abstract: A rollable pallet for insertion into an open end of a container compartment or a semi-trailer compartment. The pallet includes a rectangular frame having a flat base plate adapted to rest on the floor of the container compartment. The front end of the frame is elevated and a roller which also rests on the floor is mounted thereon to provide support for the frame and to provide a pivot about which the frame is tilted when the rear end of the frame is lifted. When tilted the pallet is rollable on the floor of the container.
    Type: Grant
    Filed: July 1, 1987
    Date of Patent: May 30, 1989
    Inventors: James Darnell, Ralph Defalco