Patents by Inventor James David Ross
James David Ross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11918801Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: GrantFiled: November 5, 2021Date of Patent: March 5, 2024Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth UniversityInventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
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Publication number: 20230380743Abstract: Systems, devices, and methods for interfacing with biological tissue are described herein. An example electrode patch as described herein includes a flexible substrate and an electrode array arranged on the flexible substrate. The electrode array includes a plurality of electrodes, where each of the plurality of electrodes is formed of a hydrogel. Additionally, each of the plurality of electrodes defines a raised geometry. Additionally, an example system includes the electrode patch, which is configured to interface with a subject's skin, and an electronics module operably coupled to the electrode array.Type: ApplicationFiled: March 21, 2023Publication date: November 30, 2023Inventors: Isaac Perry Clements, Anna Harrison, Edgar Brown, Amanda Preyer, James David Ross, Andrew Willsie, Maximilian Sonntag
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Patent number: 11612344Abstract: Systems, devices, and methods for interfacing with biological tissue are described herein. An example electrode patch as described herein includes a flexible substrate and an electrode array arranged on the flexible substrate. The electrode array includes a plurality of electrodes, where each of the plurality of electrodes is formed of a hydrogel. Additionally, each of the plurality of electrodes defines a raised geometry. Additionally, an example system includes the electrode patch, which is configured to interface with a subject's skin, and an electronics module operably coupled to the electrode array.Type: GrantFiled: November 4, 2019Date of Patent: March 28, 2023Assignee: BioCircuit Technologies, Inc.Inventors: Isaac Perry Clements, Anna Harrison, Edgar Brown, Amanda Preyer, James David Ross, Andrew Willsie, Maximilian Sonntag
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Publication number: 20220349869Abstract: A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions.Type: ApplicationFiled: January 27, 2020Publication date: November 3, 2022Inventors: Michael Antony CLEMENTS, Isaac Perry CLEMENTS, Thomas J. O'BRIEN, James David ROSS, Daniel Christopher MILLARD, Andrew WILLSIE, Edgar A. BROWN, Robert Dixon GRIER, Jr., Amanda Jervis PREYER, Denise Danielle SULLIVAN
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Publication number: 20220054824Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: ApplicationFiled: November 5, 2021Publication date: February 24, 2022Inventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
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Patent number: 11167131Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: GrantFiled: May 3, 2021Date of Patent: November 9, 2021Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth UniversityInventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
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Publication number: 20210252282Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.Type: ApplicationFiled: May 3, 2021Publication date: August 19, 2021Inventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
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Patent number: 10994130Abstract: An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve.Type: GrantFiled: September 6, 2017Date of Patent: May 4, 2021Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth UniversityInventors: Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach, Jonathan Isaacs
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Patent number: 10989703Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.Type: GrantFiled: June 7, 2019Date of Patent: April 27, 2021Assignee: Axion BioSystems, Inc.Inventors: Isaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
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Patent number: 10969382Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.Type: GrantFiled: April 27, 2018Date of Patent: April 6, 2021Assignee: AXION BIOSYSTEMS, INC.Inventors: Stacie Ann Chvatal, Daniel Christopher Millard, James David Ross
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Publication number: 20200138313Abstract: Systems, devices, and methods for interfacing with biological tissue are described herein. An example electrode patch as described herein includes a flexible substrate and an electrode array arranged on the flexible substrate. The electrode array includes a plurality of electrodes, where each of the plurality of electrodes is formed of a hydrogel. Additionally, each of the plurality of electrodes defines a raised geometry. Additionally, an example system includes the electrode patch, which is configured to interface with a subject's skin, and an electronics module operably coupled to the electrode array.Type: ApplicationFiled: November 4, 2019Publication date: May 7, 2020Inventors: Isaac Perry Clements, Anna Harrison, Edgar Brown, Amanda Preyer, James David Ross, Andrew Willsie, Maximilian Sonntag
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Publication number: 20200003753Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.Type: ApplicationFiled: June 7, 2019Publication date: January 2, 2020Inventors: Isaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
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Patent number: 10351812Abstract: Systems and methods for creating a localized environment for a cell culture plate are described herein. An example system can include a dock shaped to receive the cell culture plate, and a gas distribution device positioned on the dock. The gas distribution device can include a frame including a plurality of sides connected to form an opening, an internal channel within the frame for directing a gas mixture within the gas distribution device, an inlet port in fluid communication with the internal channel for receiving the gas mixture, and a plurality of apertures in fluid communication with the internal channel. The plurality of apertures can be spaced apart from one another along the frame and configured to direct the gas mixture toward the opening.Type: GrantFiled: August 28, 2015Date of Patent: July 16, 2019Assignee: AXION BIOSYSTEMS, INC.Inventors: Robert Dixon Grier, Jr., David Ernest Irvine, James David Ross
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Patent number: 10317391Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.Type: GrantFiled: June 6, 2016Date of Patent: June 11, 2019Assignee: Axion BioSystems, Inc.Inventors: Isaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
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Publication number: 20180292389Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.Type: ApplicationFiled: April 27, 2018Publication date: October 11, 2018Inventors: Stacie Ann Chvatal, Daniel Christopher Millard, James David Ross
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Patent number: 9983198Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.Type: GrantFiled: March 21, 2016Date of Patent: May 29, 2018Assignee: Axion BioSystems, Inc.Inventors: Stacie Ann Chvatal, Daniel Christopher Millard, James David Ross
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Publication number: 20180064931Abstract: An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve.Type: ApplicationFiled: September 6, 2017Publication date: March 8, 2018Inventors: Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach, Jonathan Isaacs
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Publication number: 20170058246Abstract: Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein.Type: ApplicationFiled: August 28, 2015Publication date: March 2, 2017Inventors: Robert Dixon Grier, JR., David Ernest Irvine, James David Ross
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Publication number: 20170038361Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.Type: ApplicationFiled: June 6, 2016Publication date: February 9, 2017Inventors: Isaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
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Publication number: 20160274088Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.Type: ApplicationFiled: March 21, 2016Publication date: September 22, 2016Inventors: Stacie Ann Chvatal, Daniel Christopher Millard, James David Ross