Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.

Abstract: An indexed cable arrangement can be installed in a re-enterable housing. The optical fibers of the cable are indexed between a first; ruggedized multi-fiber connector and a second multi-fiber connector. The second multi-fiber connector may be non-ruggedized and disposed within the housing (e.g., at an adapter) or ruggedized and disposed external of the housing (e.g., terminating a stub cable). One or more drop lines are terminated by respective non-ruggedized, single-fiber connectors disposed within the housing. In certain examples, drop lines may be split into multiple connectorized single-fiber outputs.

Abstract: An indexed cable arrangement can be installed in a re-enterable housing. The optical fibers of the cable are indexed between a first; ruggedized multi-fiber connector and a second multi-fiber connector. The second multi-fiber connector may be non-ruggedized and disposed within the housing (e.g., at an adapter) or ruggedized and disposed external of the housing (e.g., terminating a stub cable). One or more drop lines are terminated by respective non-ruggedized, single-fiber connectors disposed within the housing. In certain examples, drop lines may be split into multiple conneaorized single-fiber outputs.

Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.

Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.

Abstract: A flat drop cable has notches or other structures for enhancing the stripability of the jacket from the a core of the flat drop cable. The notches can have an angled configuration with surfaces that converge as the notch extends into the jacket. Inner edges of the notches can be positioned along a tear path that intersects the core of the flat drop cable. For example, the notches can be offset from a minor axis of the flat drop cable a sufficient distance such that the notches are positioned outside a central boundary region that extends tangent to sides of the core and parallel to the minor axis of the flat drop cable.

Abstract: A flat drop cable has notches or other structures for enhancing the stripability of the jacket from the a core of the flat drop cable. The notches can have an angled configuration with surfaces that converge as the notch extends into the jacket. Inner edges of the notches can be positioned along a tear path that intersects the core of the flat drop cable. For example, the notches can be offset from a minor axis of the flat drop cable a sufficient distance such that the notches are positioned outside a central boundary region that extends tangent to sides of the core and parallel to the minor axis of the flat drop cable.

Abstract: A flat drop cable has notches or other structures for enhancing the stripability of the jacket from the a core of the flat drop cable. The notches can have an angled configuration with surfaces that converge as the notch extends into the jacket. Inner edges of the notches can be positioned along a tear path that intersects the core of the flat drop cable. For example, the notches can be offset from a minor axis of the flat drop cable a sufficient distance such that the notches are positioned outside a central boundary region that extends tangent to sides of the core and parallel to the minor axis of the flat drop cable.

Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.

Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors. In particular, the present invention provides an adenovirus vector comprising a capsid derived from chimpanzee adenovirus AdY25, wherein said capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest.

Abstract: A flat drop cable has notches or other structures for enhancing the stripability of the jacket from the a core of the flat drop cable. The notches can have an angled configuration with surfaces that converge as the notch extends into the jacket. Inner edges of the notches can be positioned along a tear path that intersects the core of the flat drop cable. For example, the notches can be offset from a minor axis of the flat drop cable a sufficient distance such that the notches are positioned outside a central boundary region that extends tangent to sides of the core and parallel to the minor axis of the flat drop cable.

Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors. In particular, the present invention provides an adenovirus vector comprising a capsid derived from chimpanzee adenovirus AdY25, wherein said capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest.

Abstract: In a tapping mode Atomic Force Microscope (AFM) system, a probe is excited at an excitation frequency other than the probe's first natural frequency to produce a response signal manifesting a grazing bifurcation between “non-collision” and “collision” states of the AFM system, so that an additional characteristic frequency component is generated in the “collision” state. The magnitude of the additional characteristic frequency component is monitored in real time, and the probe-sample separation is adjusted to maintain the monitored magnitude at an optimal value to operate the AFM system at near-grazing conditions.

Abstract: In a tapping mode Atomic Force Microscope (AFM) system, a probe is excited at an excitation frequency other than the probe's first natural frequency to produce a response signal manifesting a grazing bifurcation between “non-collision” and “collision” states of the AFM system, so that an additional characteristic frequency component is generated in the “collision” state. The magnitude of the additional characteristic frequency component is monitored in real time, and the probe-sample separation is adjusted to maintain the monitored magnitude at an optimal value to operate the AFM system at near-grazing conditions.

Abstract: The invention provides anti-microbial compositions, including compositions with inhibitory activity against mycobacteria. The invention further provides methods for treating microbial infections, including the treatment of mycobacterial infection and diseases such as tuberculosis.

Abstract: The present invention involves a digital audio player and a method for processing encoded digital audio data, wherein the digital audio data is encoded using one of a plurality of encoding formats. The audio data player has a hard disk or other data storage medium for storing data files, a microcontroller, buffer memory for anti-skip protection, and an audio decoder. The encoded audio data files and associated decoder files are downloaded from a personal computer or similar device to the audio data player hard drive. The player provides a menu-driven user interface for selection, sorting, and playback of stored audio data files. During playback, elapsed playback time is computed and displayed. For variable bit-rate audio data files, the audio data player generates an elapsed playback timekeeping map concurrently with playback and fast forward scan of audio data files.

Abstract: An apparatus and a method for processing encoded digital audio data, wherein the digital audio data is encoded using one of a plurality of encoding formats. The present invention prevents encoded digital audio data that has been copied onto a particular type of data storage medium having a unique identifier, such as a compactflash memory card, from another one of the particular type of data storage medium from being playable in an audio playback device according to the present invention. In accordance with the present invention, an encoded audio data file is encrypted using a unique identifier associated with the data storage device and a second key, an associated decoder file is encrypted using a first key, and the encrypted data and decoder files are stored onto the data storage device. During playback, a digital signal processor decrypt the audio data file in response to the second key and decrypts the decoder file in response to the first key.

Abstract: A method of treating a subject with a microbially-based infection, comprising the administration of a compound to the subject. The compound is able to decrease ATP levels in the microbe by at least 10% compared to controls after 24 hours in an in vitro test, without killing mammalian cells during the same time period. The decrease in ATP levels is measured by: (1) removing the cells from the testing location and putting them on ice; (2) harvesting the cells at 4 degrees C. by centrifugation and disrupting it with bead-beating in an ATP extraction buffer; (3) removing cellular debris by centrifugation at 4 degrees C., leaving an ATP-containing supernatant; (4) measuring the amount of ATP present in the supernatant by a bioluminescence assay at 4 degrees C.

Abstract: A liquid retaining pressure relief valve for electrochemical battery cells is provided including a pressure regulator and a membrane vent that are mounted to the top and bottom ends of a threaded valve housing or plug. The valve housing or plug screws into the cell cover from the outside of the cell such that the membrane vent is internal to the cell. The membrane vent includes a thin gas permeable liquid repellant membrane that is molded into the body of the vent. The membrane is preferably composed of an expanded polytetraflouroethylene (ePTFE) polymer.

Abstract: The present invention involves a digital audio player and a method for processing encoded digital audio data, wherein the digital audio data is encoded using one of a plurality of encoding formats. The audio data player has a hard disk or other data storage medium for storing data files, a microcontroller buffer memory for anti-skip protection, and an audio decoder. The encoded audio data files and associated decoder files are downloaded from a personal computer or similar device to the audio data player hard drive. The player provides a menu-driven user interface for selection, sorting, and playback of stored audio data files. During playback, elapsed playback time is computed and displayed. For variable bit-rate audio data files, the audio data player generates an elapsed playback timekeeping map concurrently with playback and fast forward scan of audio data files.