Abstract: A communication network device facilitates communication between devices and/or applications in a network without requiring each device to register with every other device or application. The communication network device may generate and assign a unique identifier to each device or application upon registration and store a role of the device or application (e.g., sender or receiver or both) in addition to capability and compatibility information. The communication network device may then dynamically broker and manage communications from each of the devices or applications to other devices and applications in real-time. Using a communication network device, communications may be directed to devices or applications without requiring a sending device to know of the recipient's network address. Additionally, the communication network device allows for the direct targeting of communications to specific applications.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: A system and method of adding a high-rate channel to a legacy baseband bus includes a bus communicatively coupled to a transmitter and a receiver via one or more transformer couplers, where the transmitter and receiver transmit and receive a first signal over the bus utilizing a differential mode. The system also includes at least two modems coupled to the bus, where a first modem transmits a second signal over the bus for receipt by a second modem, where the at least two modems are each coupled to the bus via the one or more transformer couplers, where the second signal is transmitted over the bus utilizing a common mode, and where the first signal and the second signal are spatially separated on the bus based on an isolation between the common mode and the differential mode.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: An adjustable scaffolding tunnel assembly. The assembly includes a first pair of posts connected on upper and lower portions thereof to a second pair of posts via grooved members. A first cross beam is positioned between the first pair of posts, and a second cross beam is positioned between the second pair of posts. A plurality of support beams is disposed between the first and second cross beams. The first and second pairs of posts are vertically adjustable, and the first and second cross beams and the support beams are laterally adjustable. In this manner, a height and a width of the assembly are individually adjustable. The adjustable scaffolding tunnel assembly can hold one or more isolation members, such as wood or drywall, to isolate an interior of the assembly from an exterior of the assembly.

Abstract: An adjustable scaffolding tunnel assembly. The assembly includes a first pair of posts connected on upper and lower portions thereof to a second pair of posts via grooved members. A first cross beam is positioned between the first pair of posts, and a second cross beam is positioned between the second pair of posts. A plurality of support beams is disposed between the first and second cross beams. The first and second pairs of posts are vertically adjustable, and the first and second cross beams and the support beams are laterally adjustable. In this manner, a height and a width of the assembly are individually adjustable. The adjustable scaffolding tunnel assembly can hold one or more isolation members, such as wood or drywall, to isolate an interior of the assembly from an exterior of the assembly.

Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.

Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.

Abstract: The invention relates to apH mediated cell delivery vehicle comprising: a cargo or a cargo-binding molecule for binding to a cargo; a protein transduction domain; and a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell, wherein the GAG binding element is a peptide which is modified to comprise one or more histidine residues which are capable of being protonated in an acidic environment. The invention further relates to the use of such a delivery vehicle including methods of treatment, such as treatment for cancer.

Abstract: A rear fairing system for a vehicle includes a roof foil on top of the vehicle roof and sidewall foils pivotally mounted to the vehicle sidewalls. The roof foil includes downwardly facing concavity and a roof foil curved convex upper surface extending laterally across the vehicle roof. A spring extends laterally across the vehicle roof in the downwardly facing concavity. A door foil extends aft of the roof foil with a curved convex upper surface continuing the roof foil curved convex upper surface. Cables extend from the vehicle rear doors to the sidewall foils adjacent the sidewall foil free edges. The cables are taut and strain the sidewall foils toward the vehicle rear doors with the vehicle rear doors closed.

Abstract: A pressure support device such as a CPAP machine, is provided, which includes a housing, and a controller enclosed by the housing. The controller operates the CPAP machine independently or in combination with an accessory such as, for example and without limitation, a humidifier. A user interface is operably coupled to the controller and includes a primary display, a secondary display and a single control. The single control is operable in a first mode of operation to adjust operating parameters of the CPAP machine, and in a second mode of operation to adjust operating parameters of the humidifier. The secondary display preferably comprises a dead front, which is operational (e.g., without limitation, visible) only in the second mode of operation. A method of operating a pressure support device is also disclosed.

Abstract: A rear fairing system for a vehicle includes a roof foil on top of the vehicle roof and sidewall foils pivotally mounted to the vehicle sidewalls. The roof foil includes downwardly facing concavity and a roof foil curved convex upper surface extending laterally across the vehicle roof. A spring extends laterally across the vehicle roof in the downwardly facing concavity. A door foil extends aft of the roof foil with a curved convex upper surface continuing the roof foil curved convex upper surface. Cables extend from the vehicle rear doors to the sidewall foils adjacent the sidewall foil free edges. The cables are taut and strain the sidewall foils toward the vehicle rear doors with the vehicle rear doors closed.

Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.

Abstract: In order to facilitate access to and exchange of a given content item in a sequential set of content items (such as a slide in a presentation or a frame in a video), a system may create a clipped-content identifier in response to a clip selection of the content item by a user. This clipped-content identifier may include a pointer to a location in the system that stores the content item in the sequential set of content items, and metadata associated with the content item. Subsequently, the system may present a clipped-content summary document to the user, which allows the user to download, edit, share, and aggregate one or more clip selections in sequential sets of content items.

Abstract: Methods and systems for interpersonal coordination analysis and training are provided. In an example embodiment of a method for interpersonal coordination analysis and training, at least one physical action is selected to be performed. A leader subject is instructed to perform the at least one physical action in the presence of at least one follower subject. The at least one physical action of the leader subject is tracked. The at least one follower subject is instructed to mimic the at least one physical action of the leader subject. The at least one physical action of the at least one follower subject is tracked. Tracking data obtained from the tracking of the leader subject and the at least one follower subject is analyzed. From the analyzing of the tracking data, a responsiveness of the at least one follower subject to mimic the leader subject can be determined.

Abstract: A hyperspectral imaging system and a method are described herein for providing a hyperspectral image of an area of a remote object. In one aspect, the hyperspectral imaging system includes a fore optic with optics for acquiring and projecting an image from a remote object, a scannable slit mechanism with a plurality of slits for receiving the projected image, where the projected image simultaneously illuminates two or more of the plurality of slits, a spectrometer for receiving and dispersing images passing through the two or more simultaneously-illuminated slits, and a two-dimensional image sensor for recording images received from the spectrometer, where the images received from different slits are recorded on different sets of detection elements of the two-dimensional image sensor.