Abstract: The present application provides materials and methods for treating a patient with Amyotrophic Lateral Sclerosis (ALS). In addition, the present application provides materials and methods for (1) modifying the transcription start site of exon1a to render the transcription start site non-functioning, (2) deleting the transcription site of exon1a, (3) deleting exon1a, or (4) deleting of the expanded hexanucleotide repeat within or near the C9ORF72 gene, or any combinations of (1)-(4), above in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with Amyotrophic Lateral Sclerosis (ALS). In addition, the present application provides materials and methods for (1) modifying the transcription start site of exon1a to render the transcription start site non-functioning, (2) deleting the transcription site of exon1a, (3) deleting exon1a, or (4) deleting of the expanded hexanucleotide repeat within or near the C9ORF72 gene, or any combinations of (1)-(4), above in a cell by genome editing.

Abstract: Processing apparatus in the form of a parallel processing configuration having a plurality of processors and at least one shared memory that is shared between the processors. Each processor is operated at a clock speed that is lower than the clock speed of the memory.

Abstract: A circuit is for sampling an analog input signal that receives and samples an analog input signal. Sampling circuitry is clocked at a sampling frequency and samples the analog input signal at a rate corresponding to the sampling frequency. The sampling circuitry includes at least one pulse density modulator that includes a comparator configured to be clocked at the sampling frequency, to provide bandpass sampling of the analog input signal at the sampling frequency, and to produce a corresponding pulsed output that is pulse density modulated based on the analog input signal.

Abstract: A modulator circuit includes a plurality of signal processing branches, each branch having a modulator for performing a delta-sigma modulation of a respective data stream portion in order to generate a modulated signal. The modulator circuit receives an input data stream having a carrier frequency; splits the input data stream into a plurality of data stream portions. Delta-sigma modulation is performed in each branch on a respective data stream portion. The respective modulated signals from each branch are combined to form an output signal for outputting at the carrier frequency.

Abstract: A modulator circuit includes a plurality of signal processing branches, each branch having a modulator for performing a delta-sigma modulation of a respective data stream portion in order to generate a modulated signal. The modulator circuit receives an input data stream having a carrier frequency; splits the input data stream into a plurality of data stream portions. Delta-sigma modulation is performed in each branch on a respective data stream portion. The respective modulated signals from each branch are combined to form an output signal for outputting at the carrier frequency.

Abstract: Processing apparatus in the form of a parallel processing configuration having a plurality of processors and at least one shared memory that is shared between the processors. Each processor is operated at a clock speed that is lower than the clock speed of the memory.

Abstract: A circuit is for sampling an analog input signal that receives and samples an analog input signal. Sampling circuitry is clocked at a sampling frequency and samples the analog input signal at a rate corresponding to the sampling frequency. The sampling circuitry includes at least one pulse density modulator that includes a comparator configured to be clocked at the sampling frequency, to provide bandpass sampling of the analog input signal at the sampling frequency, and to produce a corresponding pulsed output that is pulse density modulated based on the analog input signal.

Abstract: Methods are provided for selecting a bacterium capable of reducing pathogenic bacterial colonization of the intestinal tract in a subject comprising selecting the bacterium capable of migrating at least 0.75 cm from the point of inoculation on motility agar after incubation for 24 hours at 37° C. or capable of migrating from the point of inoculation to a diameter of at least 1.5 cm based on the farthest colonies from the point of inoculation on motility agar after incubation for 24 hours at 37° C. Bacteria selected using the method and compositions comprising these bacteria are also provided.

Abstract: Methods are provided for selecting a bacterium capable of reducing pathogenic bacterial colonization of the intestinal tract in a subject comprising selecting the bacterium capable of migrating at least 0.75 cm from the point of inoculation on motility agar after incubation for 24 hours at 37° C. or capable of migrating from the point of inoculation to a diameter of at least 1.5 cm based on the farthest colonies from the point of inoculation on motility agar after incubation for 24 hours at 37° C. Bacteria selected using the method and compositions comprising these bacteria are also provided.

Abstract: A receiver (10) for receiving a wireless communication signal, such as a UWB signal, is operable in a first mode when the receiver is actively receiving a transmitted signal, and a second mode when the receiver is waiting to receive a transmitted signal. The receiver comprises an analogue-to-digital converter (20) for converting a received analogue signal into a digital signal. A receiver controller is adapted to control the operating resolution of the analogue to digital converter such that, in the first mode, the analogue-to-digital converter (20) operates at a first resolution, and, in the second mode, the analogue-to-digital converter (20) operates at a second resolution. The second resolution is lower than the first resolution, and preferably the second resolution is a 1-bit resolution.

Abstract: The present invention provides a method of packaging goods having a liquid element, said liquid element comprising dissolved gases, wherein the liquid element is treated prior to the goods being subjected to a vacuum packing process, such that a substantial volume of the dissolved gages do not escape from said liquid element during said vacuum packing process. Suitable methods of treatment of the liquid element include subjecting the liquid element to a gas removal process and subjecting the liquid element to a freezing process.

Abstract: A vertical glazing frame system for building curtain walls includes a sill assembly having a subsill shaped and dimensioned for direct attachment to a support structure and a sill shaped and dimensioned for receipt within the subsill for ease of installation and movement relative thereto. The system also includes a head assembly having a head receptor shaped and dimensioned for direct attachment to a support and a head shaped and dimensioned for receipt within the head receptor for movement relative thereto. The system further includes a jamb assembly and flashing plate extending over the sill assembly and the head assembly, the flashing plate including a first end coupled to the sill assembly and a second end covering the head assembly.

Abstract: A vertical glazing frame system for building curtain walls includes a sill assembly having a subsill shaped and dimensioned for direct attachment to a support structure and a sill shaped and dimensioned for receipt within the subsill for ease of installation and movement relative thereto. The system also includes a head assembly having a head receptor shaped and dimensioned for direct attachment to a support and a head shaped and dimensioned for receipt within the head receptor for movement relative thereto. The system further includes a jamb assembly and flashing plate extending over the sill assembly and the head assembly, the flashing plate including a first end coupled to the sill assembly and a second end covering the head assembly.