Abstract: The invention relates to a method of expanding a population of regulatory T cells in a tissue or organ of a subject, wherein said method comprises administration of IL-2 and a targeting moiety specific for said tissue or organ, and wherein said tissue or organ is the central and/or peripheral nervous system. The invention further relates to populations of regulatory T cells produced according to the method and the production of said population in vivo. Also provided is a pharmaceutical composition comprising IL-2 and a targeting moiety as defined herein as well as a method of treating a disease or disorder mediated by inflammation or for the reduction of inflammation which comprises the methods defined herein or administration of a pharmaceutical composition as defined herein.

Abstract: Systems, methods, and apparatuses for programming and debugging electronic devices using a near field communications device are provided. One apparatus includes an electronic device (101). The electronic device can include a microcontroller (102), wherein the microcontroller includes a bootloader (104), a device memory (103), and a processor configured to execute instructions stored on the device memory. A near field communications (NFC) interface (106) can be in communication with the microcontroller. An antenna (108) can be in communication with the NFC interface and can be configured to be energized by a signal received from an external NFC device (109). An interface memory can be in communication with the NFC interface (106), wherein the interface memory is configured to store data received from the external NFC device, the data included in the signal received from the external NFC device.

Abstract: A method for executing a security stack can include executing a bootloader included in a memory resource of an electronic device in response to the bootloader receiving a prompt. The method can include performing a verification function, with the bootloader, on data stored in a programmable memory included in the memory resource of the electronic device, wherein the verification function includes comparing security data stored in a configuration area of the memory resource with a signature that accompanies the data stored in the programmable memory. The method can include determining whether the security data stored in the configuration area matches the signature that accompanies the data stored in the programmable memory.

Abstract: An interface device configured to interface with one or more aircraft avionics data systems and an antenna. The interface device includes a radio and at least one computing device that are housed inside an enclosure. The radio is connected to the antenna. The radio is configured to transmit outgoing messages and to receive incoming messages via the antenna. The at least one computing device is configured to send the outgoing messages to the radio for transmission by the radio via the antenna and to receive the incoming messages from the radio. The radio may be a very high frequency (“VHF”) transceiver.

Abstract: An interface device configured to interface with one or more aircraft avionics data systems and an antenna. The interface device includes a radio and at least one computing device that are housed inside an enclosure. The radio is connected to the antenna. The radio is configured to transmit outgoing messages and to receive incoming messages via the antenna. The at least one computing device is configured to send the outgoing messages to the radio for transmission by the radio via the antenna and to receive the incoming messages from the radio. The radio may be a very high frequency (“VHF”) transceiver.

Abstract: A method for executing a security stack can include executing a bootloader included in a memory resource of an electronic device in response to the bootloader receiving a prompt. The method can include performing a verification function, with the bootloader, on data stored in a programmable memory included in the memory resource of the electronic device, wherein the verification function includes comparing security data stored in a configuration area of the memory resource with a signature that accompanies the data stored in the programmable memory. The method can include determining whether the security data stored in the configuration area matches the signature that accompanies the data stored in the programmable memory.

Abstract: Systems, methods, and apparatuses for programming and debugging electronic devices using a near field communications device are provided. One apparatus includes an electronic device (101). The electronic device can include a microcontroller (102), wherein the microcontroller includes a bootloader (104), a device memory (103), and a processor configured to execute instructions stored on the device memory. A near field communications (NFC) interface (106) can be in communication with the microcontroller. An antenna (108) can be in communication with the NFC interface and can be configured to be energized by a signal received from an external NFC device (109). An interface memory can be in communication with the NFC interface (106), wherein the interface memory is configured to store data received from the external NFC device, the data included in the signal received from the external NFC device.

Abstract: The methodology described herein provides a process of interaction between a Bluetooth beacon or other wireless beacon and a user-device. Embodiments of the method may allow the user-device to cryptographically verify the identity and provider of the beacon. Only if the user-device has a record of trust with the beacon provider may the beacon be considered trustworthy. The process may be automatic and may be convenient for the user who can then assess the trustworthiness of a beacon for further ad-hoc interaction without compromising the user-experience. This may be achieved without the need for a third-party, making it robust to situations where a user-device internet-connection is unavailable, unreliable or undesirable.

Abstract: The reputation of an executable computer program is checked when a user input to a computing device initiates a program launch, thus triggering a check of a local cache of reputation information. If the local cache confirms that the program is safe, it is permitted to launch, typically without notifying the user that a reputation check has been made. If the local cache cannot confirm the safety of the program, a reputation check is made by accessing a reputation service in the cloud. If the reputation service identifies the program as safe, it returns an indication to the computing device and the program is permitted to be launched, again without notifying the user that a reputation check has been made. If the reputation service identifies the program as unsafe or potentially unsafe, or does not recognize it at all, a warning is displayed to the user.

Abstract: The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.

Abstract: The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.

Abstract: The reputation of an executable computer program is checked when a user input to a computing device initiates a program launch, thus triggering a check of a local cache of reputation information. If the local cache confirms that the program is safe, it is permitted to launch, typically without notifying the user that a reputation check has been made. If the local cache cannot confirm the safety of the program, a reputation check is made by accessing a reputation service in the cloud. If the reputation service identifies the program as safe, it returns an indication to the computing device and the program is permitted to be launched, again without notifying the user that a reputation check has been made. If the reputation service identifies the program as unsafe or potentially unsafe, or does not recognize it at all, a warning is displayed to the user.

Abstract: A universal content representation system (“UCRS”) implements techniques for universally representing digital content such as files, device information, and applications across a group of electronic devices that includes at least a source electronic device and a remote electronic device. Proxy content items, which correspond with items of content (“source content items”) stored on the source electronic device, are data stores for the corresponding source content items, and visually represent the corresponding source content items on the remote electronic device, whether the source electronic device is online or offline. A user of the remote electronic devices uses the proxy content items to search for and view source content items prior to requesting full access to the source content items. From time-to-time, source content items and proxy content items are synchronized with each other.

Abstract: The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salths thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.

Abstract: This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-aminomethyl-5-methyl-octanoic acid.

Abstract: A pocketed panel assembly for a vehicle door is disclosed herein. The pocketed panel assembly includes a trim panel, a partial pocket structure, and a living hinge. The trim panel has a pivotal edge, and the partial pocket structure also has a pivotal edge. The living hinge integrally joins the pivotal edge of the trim panel to the pivotal edge of the partial pocket structure. In such a configuration, the partial pocket structure can be rotated about the living hinge and substantially abutted against the trim panel so as to form an open pocket on the trim panel.

Abstract: This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S, 5R)-3-aminomethyl-5-methyl-octanoic acid.

Abstract: This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.

Abstract: A pocketed panel assembly for a vehicle door is disclosed herein. The pocketed panel assembly includes a trim panel, a partial pocket structure, and a living hinge. The trim panel has a pivotal edge, and the partial pocket structure also has a pivotal edge. The living hinge integrally joins the pivotal edge of the trim panel to the pivotal edge of the partial pocket structure. In such a configuration, the partial pocket structure can be rotated about the living hinge and substantially abutted against the trim panel so as to form an open pocket on the trim panel.