Abstract: A method of compressing a color image is provided. The color image comprises color data for a plurality of pixels. The method includes the step of obtaining red, green and blue pixel values of an object of interest in the image. A calculation is made of the complement of the red, green and blue values of the object of interest. Transformation coefficients are calculated which transform the complements of red, green and blue values of the object of interest into representations in a transformation color space. The transformation coefficients are applied to all the pixels in the image to thereby obtain a transformed data set representing the image having components along three mutually orthogonal axes (A, B and C herein) in a three-dimensional transformed color space. The transformed data set is scaled in accordance with the color quantization used in the system; e.g., the A, B and C values are between 0 and 255 for an 8 bit quantization. A compression algorithm, e.g.

Abstract: A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.

Abstract: The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a nucleoside 5?-pyrophosphate pyranoside or analogue, which is defined by general Formula I. The method of the present invention is useful in the treatment or prevention of ocular hypertension, such as found in glaucoma, including primary and secondary glaucoma. The method can be used alone to reduce intraocular pressure. The method can also be used in conjunction with another therapeutic agent or adjunctive therapy commonly used to treat glaucoma to enhance the therapeutic effect of reducing the intraocular pressure. The present invention also provides a novel composition comprising a nucleoside 5?-pyrophosphate pyranoside or analogue.

Abstract: A method of compressing a color image is provided. The color image comprises color data for a plurality of pixels. The method includes the step of obtaining red, green and blue pixel values of an object of interest in the image. A calculation is made of the complement of the red, green and blue values of the object of interest. Transformation coefficients are calculated which transform the complements of red, green and blue values of the object of interest into representations in a transformation color space. The transformation coefficients are applied to all the pixels in the image to thereby obtain a transformed data set representing the image having components along three mutually orthogonal axes (A, B and C herein) in a three-dimensional transformed color space. The transformed data set is scaled in accordance with the color quantization used in the system; e.g., the A, B and C values are between 0 and 255 for an 8 bit quantization. A compression algorithm, e.g.

Abstract: Two color transformations, as described herein, facilitate identification of the objects of interest in the biological specimen. One of the color transformations, a Minus Clear Plus One (MC+1) transformation, can be conceptualized as either translating and rotating axes of a three-dimensional coordinate space that defines an image of the biological specimen or calculating differences between vectors in the three dimensional coordinate space that defines the image of the biological specimen. The other of the color transformations, a Quantitative Chromatic Transformation (QCT),is a colorimetric transformation that produces three new quantitities from the original red, green, and blue pixel values for each color pixel of an image. These three new quantities, X, Y, and Z can each be related to the quantitative amount of absorbing molecules sampled by that pixel.

Abstract: A device useful for loading, unloading, and securing cargo to be transported by a vehicle is described. The device comprises a bed liner and a movable platform. The moveable platform is movably inserted into a platform receiving area located in the bed liner and platform movement is limited by use of stop pins inserted into pin apertures. Suitable insert for use securing a variety of different loads are also described.

Abstract: A user of a first device may select at least one multimedia presentation. Based on this selection, the multimedia presentation is accessed from a storage source and presented to the user. Simultaneously, information is transmitted to at least a second device that causes the selected multimedia presentation to be presented by the at least second device without the at least second device receiving input from a second user. Continuous media streams from the first user may be captured and transmitted to the second device(s). The presenting of the multimedia presentation on the first device are coordinated with the presenting of the multimedia presentation on the second device(s). The presenting of the captured media streams on the second device(s) are coordinated with the capturing of those streams and the presenting of the multimedia presentation on the second device(s). Users may control the multimedia presentations and the captured media streams.

Abstract: The system and method for evaluating the amount of marker identifying precipitate in a cellular specimen on a microscope slide is disclosed. The automated microscope system performs a low magnification and high magnification scan of a cellular specimen to identify and confirm candidate objects of interest which correspond to cells containing a marker identifying precipitate. A regularly shaped area centered about a centroid computed for a candidate object of interest is used to define the pixels to be processed. A color ratio is computed for each pixel and those color ratios indicative of being dominated by the color corresponding to the marker identified precipitate are summed and normalized. The normalized color ratio is compared to at least one predetermined threshold to assign a grade to the candidate objects of interest. The grades for a predetermined number of candidate objects of interest are summed to form an aggregate score and the aggregate score is compared to a threshold.