Patents by Inventor James Dowell

James Dowell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PLASMA-FREE TRIFLUOROMETHYL AND HYDROXYL RADICAL LABELING
    Publication number: 20250076308
    Abstract: Provided herein are materials and methods for plasma-free labeling of biological molecules with trifluoromethyl and hydroxyl radicals generated using a peroxide and a radical precursor such as sodium triflinate. The methods provided herein find use in labeling of molecules, such as cell-membrane proteins, in live, intact cells.
    Type: Application
    Filed: September 6, 2024
    Publication date: March 6, 2025
    Inventors: Daniel Benjamin, Faraz Choudhury, Jonathan Schmitz, James Dowell, Alexis Lawton, Samantha Knott, Patric Sadecki
  • COMPOSITIONS AND METHODS FOR PLIMB-MEDIATED RADICAL LABELING IN VIVO
    Publication number: 20250076297
    Abstract: Provided herein are materials and methods for in vivo labeling of membrane proteins using plasma-induced modification of biomolecules (PLIMB).
    Type: Application
    Filed: August 28, 2024
    Publication date: March 6, 2025
    Inventors: Daniel Benjamin, Faraz Choudhury, Jonathan Schmitz, James Dowell, Alexis Lawton, Samantha Knott
  • COMPOSITIONS AND METHODS FOR MULTIPLEXED PLIMB-MEDIATED RADICAL LABELING
    Publication number: 20240400609
    Abstract: Provided herein are materials and methods for plasma-based multiplexed labeling of biological molecules. In some aspects, provided herein is an optimized method for simultaneous labeling of proteins with trifluoromethyl, nitro, and hydroxyl radicals generated by a plasma in a single reaction vial, such as for protein footprinting.
    Type: Application
    Filed: May 31, 2024
    Publication date: December 5, 2024
    Inventors: Samantha Knott, Daniel Benjamin, Faraz Choudhury, James Dowell