Patents by Inventor James Dropinski

James Dropinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal agents
    Patent number: 7863465
    Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-?-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: January 4, 2011
    Assignees: Merck Sharp & Dohme Corp., Scynexis, Inc.
    Inventors: James M. Balkovec, Frances Aileen Bouffard, Bruno Tse, James Dropinski, Dongfang Meng, Mark L. Greenlee, Michael Peel, Weiming Fan, Ahmed Mamai, Hao Liu, Keqaing Li
  • Compounds for the Treatment of Dyslipidemia and Other Lipid Disorders
    Publication number: 20080039514
    Abstract: A class of compounds having Formula I and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of developing conditions and sequelae that are associated with these diseases, such as atherosclerosis.
    Type: Application
    Filed: September 12, 2005
    Publication date: February 14, 2008
    Applicant: MERCK & CO., INC.
    Inventors: James Dropinski, Guo Shi, Yong Zhang
  • Antifungal agents
    Publication number: 20080009504
    Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-?-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
    Type: Application
    Filed: March 29, 2007
    Publication date: January 10, 2008
    Inventors: James Balkovec, Frances Bouffard, Bruno Tse, James Dropinski, Dongfang Meng, Mark Greenlee, Michael Peel, Weiming Fan, Ahmed Mamai, Hao Liu, Keqaing Li
  • Antidiabetic oxazolidinediones and thiazolidinediones
    Publication number: 20070173434
    Abstract: Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones of formula (I) are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
    Type: Application
    Filed: January 18, 2005
    Publication date: July 26, 2007
    Inventors: Guo Shi, Peter Meinke, James Dropinski, Yong Zhang
  • 2-Aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
    Publication number: 20060122242
    Abstract: A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.
    Type: Application
    Filed: January 18, 2006
    Publication date: June 8, 2006
    Inventors: Alan Adams, A. Jones, Joel Berger, James Dropinski, Alexander Elbrecht, Kun Liu, Karen MacNaul, Guo-Qiang Shi, Derek Von Langen, Gaochao Zhou