Patents by Inventor James Droste

James Droste has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Publication number: 20070203108

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: May 12, 2006

Publication date: August 30, 2007

Inventors: Eugene Thorsett, Michael Pleiss, Lee Latimer, Varghese John, Stephen Freedman, Thomas Britton, James Audia, Jon Reel, Bruce Dressman, James Droste, Steven Henry, Russell Stucky, Warren Porter
Tricyclic steroid hormone nuclear receptor modulators

Publication number: 20070088016

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).

Type: Application

Filed: December 15, 2004

Publication date: April 19, 2007

Inventors: Michael Coghlan, Prabhakar Jadhav, James Droste, Jonathan Green, Donald Matthews
Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis

Publication number: 20060223761

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease Also disclosed pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: February 2, 2004

Publication date: October 5, 2006

Applicants: Elan Pharmaceuticals, Inc., Eli Lilly & Company

Inventors: James Audia, Thomas Britton, James Droste, Beverly Folmer, George Huffman, Varghese John, Lee Latimer, Thomas Mabry, Jeffrey Nissen, Warren Porter, Jon Reel, Eugene Thorsett, Jay Tung, Jing Wu, Clark Eid, William Scott
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Publication number: 20060079499

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: December 2, 2004

Publication date: April 13, 2006

Inventors: Jing Wu, Jay Tung, Eugene Thorsett, Michael Pleiss, Jeffrey Nissen, R. Neitz, Lee Latimer, Varghese John, Stephen Freedman, Thomas Britton, James Audia, Jon Reel, Thomas Mabry, Bruce Dressman, Cynthia Cwi, James Droste, Steven Henry, Stacey McDaniel, William Scott, Russell Stucky, Warren Porter
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Publication number: 20050272666

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: December 2, 2004

Publication date: December 8, 2005

Inventors: Jing Wu, Jay Tung, Eugene Thorsett, Michael Pleiss, Jeffrey Nissen, Jeffrey Neitz, Lee Latimer, Varghese John, Stephen Freedman, Thomas Britton, James Audia, Jon Reel, Thomas Mabry, Bruce Dressman, Cynthia Cwi, James Droste, Steven Henry, Stacey McDaniel, William Scott, Russell Stucky, Warren Porter
CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Publication number: 20050215541

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: September 29, 2004

Publication date: September 29, 2005

Inventors: Jing Wu, Jay Tung, Eugene Thorsett, Michael Pleiss, Jeffrey Nissen, R. Jeffrey Neitz, Lee Latimer, Varghese John, Stephen Freedman, Thomas Britton, James Audia, Jon Reel, Thomas Mabry, Bruce Dressman, Cynthia Cwi, James Droste, Steven Henry, Stacey McDaniel, William Scott, Russell Stucky, Warren Porter
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Publication number: 20050203080

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: December 12, 2003

Publication date: September 15, 2005

Inventors: Jing Wu, Jay Tung, Eugene Thorsett, Michael Pleiss, Jeffrey Nissen, R. Neitz, Lee Latimer, Varghese John, Stephen Freedman, Thomas Britton, James Audia, Jon Reel, Thomas Mabry, Bruce Dressman, Cynthia Cwi, James Droste, Steven Henry, Stacey McDaniel, William Scott, Russell Stucky, Warren Porter
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Publication number: 20050182046

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: February 13, 2004

Publication date: August 18, 2005

Inventors: Jing Wu, Jay Tung, Eugene Thorsett, Michael Pleiss, Jeffrey Nissen, R. Neitz, Lee Latimer, Varghese John, Stephen Freedman, Thomas Britton, James Audia, Jon Reel, Thomas Mabry, Bruce Dressman, Cynthia Cwi, James Droste, Steven Henry, Stacey McDaniel, William Scott, Russell Stucky, Warren Porter
Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting ?-amyloid peptide release and/or its synthesis by use of such compounds

Patent number: 6849650

Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Grant

Filed: September 19, 2002

Date of Patent: February 1, 2005

Assignees: Athena Neurosciences, Inc., Eli Lilly Company

Inventors: Eugene D. Thorsett, Warren J. Porter, Jeffrey S. Nissen, Lee H. Latimer, James E. Audia, James Droste
Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Publication number: 20030130188

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Application

Filed: September 19, 2002

Publication date: July 10, 2003

Inventors: Eugene D. Thorsett, Warren J. Porter, Jeffrey S. Nissen, Lee H. Latimer, James E. Audia, James Droste
Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds

Patent number: 6506782

Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Type: Grant

Filed: February 27, 1998

Date of Patent: January 14, 2003

Assignees: Athena Neurosciences, Inc., Eli Lilly Company

Inventors: Eugene D. Thorsett, Warren J. Porter, Jeffrey S. Nissen, Lee H. Latimer, James E. Audia, James Droste