Abstract: This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S(?O)2NR1— and —NR1S(?O)2—; R1 is a sulfonamido substituent; and, Q2 is an acid leader group; with the proviso that if J is —S(?O)2NR1—, then Q1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.

Abstract: The present invention provides a stent for delivering drugs to a vessel in a body, including a stent framework with a plurality of micropore reservoirs formed therein using a femtosecond laser, a drug polymer positioned in the reservoirs, and a polymer layer positioned on the drug polymer. The present invention also provides a method of manufacturing a drug-polymer stent and a method of treating a vascular condition using the drug-polymer stent.

Abstract: The present invention is directed to novel pyridazine compounds of the formula I 1

Abstract: A continuous process for the production of poly(trimethylene terephthalate) is disclosed. According to the process, a liquid feed mixture comprising bis-3-hydroxypropyl terephthalate and/or low molecular weight polyesters of 1,3-propanediol and terephthalic acid, the liquid feed mixture having a mole ratio of propylene groups to terephthalate groups of 1.1 to 2.2 is fed to a prepolymerizer. Bis-3-hydroxypropyl terephthalate and the low molecular weight polyesters are continuously polymerized to form a poly(trimethylene terephthalate) prepolymer and a first stream of gaseous by-products. Poly(trimethylene terephthalate) prepolymer having a relative viscosity of at least about 5 is continuously withdrawn from the prepolymerizer and continuously fed to a final polymerizer, where it is continuously polymerized to form a higher molecular weight poly(trimethylene terephthalate) and a second stream of gaseous by-products.

Abstract: An endoluminal stent is formed in a modular construction to include at least one elongate spine and a plurality of general tube-defining modules attached to the spine, or spines, in a longitudinal array. The modules are constructed along a spine-like structure so as to form a bifurcate shape for implantation in branching or bifurcating vessels. Each module defines, in cooperation with a spine, a closed ring-like structure. Each of the modules is radially expandable from a reduced diameter, low profile configuration, in which it is readily navigated through the body passages, to an expanded diameter engageable with the inner luminal surface of the body lumen. The stent, being of modular construction, can be built to individual specifications for a specific patient. Modules are formed from a wire shaped in a flat serpentine configuration that is then wrapped in a cylindrical configuration with its free ends connected to a spine.

Abstract: Systems and methods for mounting a stent onto the balloon of a balloon catheter. In one embodiment, a kit is provided that includes two instruments, a first being a loader tool and a second being a profiler tool. The loader tool can be a handheld device that includes a handle at one end of the tool. A tube extends outwardly from the handle, and a wire extends is axially through the tube and projects outwardly from the tube. A balloon catheter can slide along the central wire until the balloon is delivered into the interior of the tube. A stent that is disposed about the periphery of the tube can be mounted onto the balloon by grasping the handle of the loader tool and pulling the handle and tube away from the catheter and stent whine the catheter and stent are maintained in a fixed relationship.

Abstract: A bolt handle adaptor is provided which enables a conventional right-hand operated bolt action rifle to be operated from the left-hand side. The adaptor is pivotally mounted to the distal end of the chamber-closing bolt of the rifle and projects to the left and to the right of the rifle. The left-hand section terminates in a gripping portion while the right-hand section terminates in a bolt gripping means which is affixed to the bolt handle of the chamber-closing bolt.