Patents by Inventor James E. Bradner

James E. Bradner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Preparing Largazole Analogs and Uses Thereof
    Publication number: 20140093449
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: July 17, 2013
    Publication date: April 3, 2014
    Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, UNIVERSITY OF NOTRE DAME DU LAC, DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
  • Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 8609678
    Abstract: The present invention relates to “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: December 17, 2013
    Assignee: Acetylon Pharmaceuticals
    Inventors: John H. Van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • Method for preparing largazole analogs and uses thereof
    Patent number: 8513290
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: August 20, 2013
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
  • Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 8394810
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: March 12, 2013
    Assignee: Acetylon Pharmaceuticals
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • Method for Preparing Largazole Analogs and Uses Thereof
    Publication number: 20120264794
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Ann E. Youngman
  • Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof
    Publication number: 20120190693
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: April 2, 2012
    Publication date: July 26, 2012
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • Method for preparing largazole analogs and uses thereof
    Patent number: 8217076
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: July 10, 2012
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk
  • Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof
    Publication number: 20120083504
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: December 2, 2011
    Publication date: April 5, 2012
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Patent number: 8148526
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 3, 2012
    Assignee: Acetylon Pharmaceuticals
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20110300134
    Abstract: The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
    Type: Application
    Filed: January 21, 2011
    Publication date: December 8, 2011
    Applicant: ACETYLON PHARMACEUTICALS
    Inventors: John H. van Duzer, Ralph Mazitschek, Walter Ogier, James E. Bradner, Guoxiang Huang, Dejian Xie, Nan Yu
  • Method for preparing largazole analogs and uses thereof
    Publication number: 20100029731
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: July 16, 2009
    Publication date: February 4, 2010
    Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, Dana-Farber Cancer Institute, Inc.
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Ann E. Youngman
  • SMALL MOLECULE PRINTING
    Publication number: 20090221433
    Abstract: The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm2.
    Type: Application
    Filed: January 3, 2007
    Publication date: September 3, 2009
    Inventors: David W. Barnes, Angela N. Koehler, James E. Bradner, Ralph Mazitschek, Stuart L. Schreiber