Patents by Inventor James E. Brown

James E. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12642805
    Abstract: Aspects of the present disclosure include methods for treating at least one of insulin resistance, diabetes, and prediabetes, and, optionally, also non-alcoholic steatohepatitis (NASH). In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25-hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27-hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24-hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: June 2, 2026
    Assignees: Medicis Pharmaceutical Corporation, Virginia Commonwealth University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Shunlin Ren, Yaping Wang, WeiQi Lin, James E. Brown, Terrence Blaschke
  • Patent number: 12642977
    Abstract: An implantable medical device comprises an electronics module comprising communication circuitry for at least one of transmitting communication signals to and receiving communication signals from an external communication device, and further comprising processing circuitry for at least one of processing sensed biological signals and generating stimulation signals for emission. An electrode arrangement serves for at least one of sensing said biological signals of a patient and emitting said stimulation signals. An electrical line extends in between the electronics module and the electrode arrangement, wherein the electrical line comprises a first line section, a second line section and a decoupling element, the first line section being electrically decoupled at RF frequencies from the second line section by the decoupling element and forming an antenna for at least one of transmitting and receiving said communication signals.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: June 2, 2026
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Jeffrey A. von Arx, Yu Wang, James E. Brown
  • Patent number: 12606928
    Abstract: Embodiments of the present technology include electroplating methods that include providing a first portion of an electrolyte feedstock to a first compartment of an electrochemical cell. The first portion of an electrolyte feedstock may be characterized by an initial metal ion concentration and an initial acid concentration. The methods may include providing a second portion of an electrolyte feedstock to a second compartment of the electrochemical cell. The second compartment and first compartment may be separated by a first membrane. The methods may include providing an acidic solution to a third compartment of the electrochemical cell. The third compartment and second compartment may be separated by a second membrane. The acidic solution may be characterized by an initial acid concentration. The methods may include applying a current to an anode of the electrochemical cell. The anode of the electrochemical cell may be disposed proximate the first compartment and across from the first membrane.
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: April 21, 2026
    Assignee: Applied Materials, Inc.
    Inventors: Paul R. McHugh, Gregory J. Wilson, Kwan Wook Roh, Kyle M. Hanson, Forrest G. Reinhart, David J. Reis, James E. Brown, Nolan L. Zimmerman
  • Publication number: 20260102410
    Abstract: Methods of treating alcoholic hepatitis (AH) are provided. For instance, the methods may comprise administering 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or a salt thereof.
    Type: Application
    Filed: October 21, 2025
    Publication date: April 16, 2026
    Inventors: Weiqi Lin, James E. Brown, Terrence Blaschke
  • Publication number: 20240256721
    Abstract: Described are techniques for infusing environmental data into a Computer-Aided Design (CAD) workspace. The techniques include replicating a physical area in a CAD workspace, where a static object of the physical area is replicated in the CAD workspace with a single set of coordinates, and where a dynamic object of the physical area is replicated in the CAD workspace with a range of coordinates representing movement. The techniques further include using the CAD workspace to enable relative sizing of a modeled object in the CAD workspace, where the relative sizing is relative to the single set of coordinates associated with the static object and the range of coordinates associated with the dynamic object.
    Type: Application
    Filed: January 31, 2023
    Publication date: August 1, 2024
    Inventors: Tyler HANSEN, James E. BROWN, Zachary A. Silverstein, Logan Bailey
  • Publication number: 20240238598
    Abstract: An implantable medical device comprises an electronics module comprising communication circuitry for at least one of transmitting communication signals to and receiving communication signals from an external communication device, and further comprising processing circuitry for at least one of processing sensed biological signals and generating stimulation signals for emission. An electrode arrangement serves for at least one of sensing said biological signals of a patient and emitting said stimulation signals. An electrical line extends in between the electronics module and the electrode arrangement, wherein the electrical line comprises a first line section, a second line section and a decoupling element, the first line section being electrically decoupled at RF frequencies from the second line section by the decoupling element and forming an antenna for at least one of transmitting and receiving said communication signals.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 18, 2024
    Applicant: BIOTRONIK SE & Co. KG
    Inventors: Jeffrey A. von Arx, Yu Wang, James E. Brown
  • Publication number: 20230372361
    Abstract: Aspects of the present disclosure include methods for treating at least one inflammatory condition, such as at least one of dental pulp inflammation, periodontal disease, skin inflammation, psoriasis, ulcerative colitis, osteoarthritis, inflammatory bowel disease (IBD), Crohn's disease, irritable bowel syndrome (IBS), Alzheimer's disease, Parkinson's disease, pancreatitis (acute and/or chronic), hepatitis (viral and/or non-viral), atherosclerosis, myocarditis, idiopathic pulmonary disorder (IPD), chronic obstructive pulmonary disorder (COPD), pneumonia, chronic inflammatory lung disease, bronchitis, asthma, chronic kidney disease (CKD), nephritis, sepsis, ankylosing spondylitis, diverticulitis, and fibromyalgia. In some cases, the at least one inflammatory condition is associated with Epstein-Ban virus infection.
    Type: Application
    Filed: June 25, 2021
    Publication date: November 23, 2023
    Inventors: Shunlin Ren, Yaping Wang, WeiQi Lin, James E. Brown, Felix Theeuwes
  • Patent number: 11798462
    Abstract: Light emitting diode display panels with an open loop amplifier resulting in better brightness accuracy and matching between multiple light emitting diode strings.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: October 24, 2023
    Assignee: APPLE INC.
    Inventors: Mohammad J. Navabi-Shirazi, Ming Gu, Alejandro Lara Ascorra, James E. Brown
  • Publication number: 20230310458
    Abstract: Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25HC3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).
    Type: Application
    Filed: February 28, 2023
    Publication date: October 5, 2023
    Inventors: Shunlin Ren, Felix Theeuwes, James E. Brown, WeiQi Lin
  • Publication number: 20230313406
    Abstract: Electroplating methods may include providing an electrolyte feedstock comprising copper to a first compartment of an electrochemical cell. The methods may include providing an acidic solution to a second compartment of the electrochemical cell. The first compartment and second compartment may be separated by a membrane. The methods may include applying a current to an anode of the electrochemical cell. The anode of the electrochemical cell may be disposed proximate the first compartment and across from the membrane. The methods may include forming an anolyte and catholyte precursor.
    Type: Application
    Filed: April 3, 2023
    Publication date: October 5, 2023
    Applicant: Applied Materials, Inc.
    Inventors: Paul R. McHugh, Forrest G. Reinhart, Gregory J. Wilson, Kwan Wook Roh, Kyle M. Hanson, James E. Brown, David J. Reis
  • Publication number: 20230313405
    Abstract: Embodiments of the present technology include electroplating methods that include providing a first portion of an electrolyte feedstock to a first compartment of an electrochemical cell. The first portion of an electrolyte feedstock may be characterized by an initial metal ion concentration and an initial acid concentration. The methods may include providing a second portion of an electrolyte feedstock to a second compartment of the electrochemical cell. The second compartment and first compartment may be separated by a first membrane. The methods may include providing an acidic solution to a third compartment of the electrochemical cell. The third compartment and second compartment may be separated by a second membrane. The acidic solution may be characterized by an initial acid concentration. The methods may include applying a current to an anode of the electrochemical cell. The anode of the electrochemical cell may be disposed proximate the first compartment and across from the first membrane.
    Type: Application
    Filed: April 3, 2023
    Publication date: October 5, 2023
    Applicant: Applied Materials, Inc.
    Inventors: Paul R. McHugh, Gregory J. Wilson, Kwan Wook Roh, Kyle M. Hanson, Forrest G. Reinhart, David J. Reis, James E. Brown, Nolan L. Zimmerman
  • Publication number: 20230285416
    Abstract: Aspects of the present disclosure include methods for treating at least one of insulin resistance, diabetes, and prediabetes, and, optionally, also non-alcoholic steatohepatitis (NASH). In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25- hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27- hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24- hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject.
    Type: Application
    Filed: June 25, 2021
    Publication date: September 14, 2023
    Inventors: Shunlin Ren, Yaping Wang, WeiQi Lin, James E. Brown, Terrence Blaschke
  • Publication number: 20230235474
    Abstract: Exemplary methods of semiconductor processing may include performing an electroplating operation on a semiconductor substrate in an electroplating bath within a vessel of an electroplating system. The methods may include removing the semiconductor substrate from the electroplating bath. The methods may include closing a valve associated with a first drain from the electroplating system. The methods may include increasing flow to a second drain from the electroplating system. The second drain may be associated with a drain channel from the vessel of the electroplating system.
    Type: Application
    Filed: January 26, 2023
    Publication date: July 27, 2023
    Applicant: Applied Materials, Inc.
    Inventors: Joel L. Cannone, Gregory J. Wilson, Douglas William Carr, James E. Brown
  • Publication number: 20230218639
    Abstract: Aspects of the present disclosure include methods for treating at least one of depression, neurodegenerative disease, multiple sclerosis, Parkinson's disease, spinocerebellar degeneration, Friedreich ataxia, ataxia-telangiectasia, progressive supranuclear palsy, Huntington's disease, striatonigral degeneration, olivopontocerebellar atrophy, Shy-Drager syndrome, schizophrenia, schizoaffective disorder, manic-depression (bipolar) disorder, disturbed or abnormal circadian entrainment, childhood Alice in Wonderland syndrome, childhood acute cerebellar ataxia, and Alzheimer's disease. In some instances, methods include treating an addiction to a drug, such as alcohol addiction, cocaine addiction or amphetamine addiction.
    Type: Application
    Filed: June 25, 2021
    Publication date: July 13, 2023
    Applicant: Virginia Commonwealth University
    Inventors: Shunlin Ren, Yaping Wang, WeiQi Lin, James E. Brown, Felix Theeuwes
  • Publication number: 20230181602
    Abstract: Methods of treating non-alcoholic steatohepatitis (NASH) are provided. For instance, the methods comprise administering 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or a salt thereof.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 15, 2023
    Inventors: WEIQI LIN, JAMES E. BROWN
  • Publication number: 20230141965
    Abstract: Methods of treating infectious diseases are provided. For instance, the methods may comprise administering at least one antimicrobial in combination with at least one oxygenated cholesterol sulfate (OCS). Methods for preventing and/or treating organ dysfunction and/or organ failure for patients with an infectious disease are described herein. Methods for preventing and/or treating tissue damage of one or more organs or organ systems for patients with an infectious disease are described herein.
    Type: Application
    Filed: February 10, 2021
    Publication date: May 11, 2023
    Inventors: SHUNLIN REN, WEIQI LIN, JAMES E. BROWN
  • Patent number: 11612609
    Abstract: Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction/failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25H-C3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: March 28, 2023
    Assignees: Durect Corporation, Virginia Commonwealth University
    Inventors: Shunlin Ren, Felix Theeuwes, James E. Brown, WeiQi Lin
  • Publication number: 20220378802
    Abstract: Methods of treating alcoholic hepatitis (AH) are provided. For instance, the methods may comprise administering 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or a salt thereof.
    Type: Application
    Filed: September 29, 2020
    Publication date: December 1, 2022
    Inventors: WEIQI LIN, JAMES E. BROWN, TERRENCE BLASCHKE
  • Patent number: 11468854
    Abstract: Aspects of the subject technology relate to control circuitry for light-emitting diodes. The control circuitry may include feedforward control and a feedback control for a power supply for the light-emitting diodes. The feedforward control may include host circuitry for the device that determines a maximum zone current, a maximum row current, and the maximum row-to-row current step for an upcoming backlight frame while a current backlight frame is being executed. A headroom voltage for the upcoming backlight frame is determined based on the maximum zone current, the maximum row current, and/or the maximum row-to-row current step and provided to the power supply so that the power supply can settle at a corresponding supply voltage before the upcoming backlight frame is executed. The feedback control utilizes dynamic thresholds determined for each backlight frame to fine tune the feedforward-determined headroom voltage.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: October 11, 2022
    Assignee: Apple Inc.
    Inventors: Vehbi Calayir, James E. Brown
  • Patent number: 11402687
    Abstract: Aspects of the subject technology relate to an electronic device with a display. The display includes a first array of light-emitting diodes of a backlight unit to generate backlight for the display with each LED including an anode and a cathode. A first switch selectively couples a power supply voltage to a common anode of the first array of LEDs to control illumination of the first array of LEDs. A first discharge switch selectively couples a first voltage level to the common anode of the first array of LEDs to discharge the common anode to prevent an undesired current path through the first array of LEDs and associated undesired illumination.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: August 2, 2022
    Assignee: Apple Inc.
    Inventors: Vehbi Calayir, James E. Brown, Bret Rothenberg