Abstract: Analyte sensors and associated insertion devices are disclosed herein. According to some embodiments, the present technology includes a sensor applicator comprising a housing having an insertion end configured to be positioned at or adjacent a user's skin at an insertion site, a needle carried by the housing and configured for insertion into the user's skin at the insertion site, and a sensor assembly comprising a base and a sensing portion extending from the base. The base is supported by the housing in a first position during insertion of the needle and configured to rotate into a second, laid-flat position on the user's skin after removal of the housing from the insertion site.

Abstract: Wearable medical devices are provided. An exemplary wearable medical device includes a printed circuit board assembly (PCBA) comprising a dielectric layer having a top surface and conductive features on the top surface of the dielectric layer. Further, the exemplary wearable medical device includes a top housing mounted directly to the top surface of the PCBA. Also, the wearable medical device includes a power source located between the top housing and the PCBA. The top housing and the dielectric layer of the PCBA encapsulates the conductive features and power source and define an outer surface of the wearable medical device.

Abstract: Wearable medical devices are provided. An exemplary wearable medical device includes a printed circuit board assembly (PCBA) comprising a dielectric layer having a top surface and conductive features on the top surface of the dielectric layer. Further, the exemplary wearable medical device includes a top housing mounted directly to the top surface of the PCBA. Also, the wearable medical device includes a power source located between the top housing and the PCBA. The top housing and the dielectric layer of the PCBA encapsulates the conductive features and power source and define an outer surface of the wearable medical device.

Abstract: A thermal therapy of body tissue with electromagnetic energy is controlled by feedback from one or more temperature sensors placed in the vicinity of the tissue to be treated. The temperature sensors are calibrated by comparing stabilized temperature values of the one or more temperature sensors against a normal range of body temperature and adjusting sensed temperature to a value within a normal body temperature range if the actual temperature value of a stabilized temperature sensor is less than the normal body temperature range. The temperature adjustment to the temperature sensor is maintained throughout the thermal therapy which reduces the risk of thermal damage to healthy tissue located near the tissue to be treated.

Abstract: A thermal therapy of body tissue with electromagnetic energy is controlled by feedback from one or more temperature sensors placed in the vicinity of the tissue to be treated. The temperature sensors are calibrated by comparing stabilized temperature values of the one or more temperature sensors against a normal range of body temperature and adjusting sensed temperature to a value within a normal body temperature range if the actual temperature value of a stabilized temperature sensor is less than the normal body temperature range. The temperature adjustment to the temperature sensor is maintained throughout the thermal therapy which reduces the risk of thermal damage to healthy tissue located near the tissue to be treated.

Abstract: A thermal therapy method includes inserting an applicator including an energy-emitting device into a body cavity such as a urethra adjacent a targeted tissue region such as a prostate, energizing the energy-emitting device, and circulating coolant between the energy-emitting device and a wall of the body cavity. The therapy is controlled by decreasing a temperature of the coolant and continually adjusting coolant temperature based on therapy parameters. The applicator, or selected tissue at a predetermined depth from the wall of the body cavity, is maintained at a temperature corresponding to a predetermined applicator temperature profile by adjusting a power level provided to the energy-emitting device.

Abstract: A thermal therapy method includes inserting a microwave antenna-containing applicator into a body cavity such as a urethra adjacent a targeted tissue region such as a prostate, energizing the microwave antenna, and circulating coolant between the microwave antenna and a wall of the body cavity. The therapy is controlled by decreasing a temperature of the coolant and continually adjusting coolant temperature based on other parameters. The applicator is maintained at a predetermined temperature set point by adjusting a power level provided to the microwave antenna. In one embodiment involving treatment of the prostate, rectal temperature is monitored and, upon sensing a rectal temperature that exceeds a predetermined threshold, the temperature of the coolant is increased to force a reduction in power provided to the microwave antenna to maintain the applicator at the predetermined temperature set point.

Abstract: A method for treating an individual with diseased prostatic tissue, such as benign prostatic hyperplasia, includes inserting a catheter into a urethra to position a microwave antenna located within the catheter adjacent a prostatic region of the urethra. A microwave antenna is then driven within a power range for applying microwave energy substantially continuously to prostatic tissue to heat the prostatic tissue surrounding the microwave antenna at a temperature and for a time period sufficient to cause necrosis of the prostatic tissue.