Patents by Inventor James E. Conway

James E. Conway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for large-scale production of recombinant AAV vectors
    Patent number: 6783972
    Abstract: Disclosed are HSV-1 amplicons that supply all necessary helper functions required for rAAV packaging and methods for their use. These HSV-1 amplicons have been shown to be capable of rescuing and replicating all forms of rAAV genomes including rAAV genomes introduced into cells by infection of rAAV virions, rAAV genomes transfected into cells on plasmids or proviral rAAV genomes integrated into cellular chromosomal DNA. Also provided are methods for preparing high-titer rAAV vector compositions suitable for gene therapy and the delivery of exogenous polynucleotides to selected host cells.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: August 31, 2004
    Assignee: University of Florida Research Foundation
    Inventors: Barry J. Byrne, James E. Conway, Gary S. Hayward, Nicholas Muzyzcka, Sergei Zolotukhin