Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: An absolute proportioning pumping system includes an electric motor assembly powering a first pump at a first flow rate and powering a second pump at a second flow rate. A proportioned fluid output includes a first fluid pumped by the first pump and a second fluid pumped by the second pump. The pumping system provides a desired ratio of the first fluid to the second fluid at the proportioned fluid output, relatively independently of pressure and flow rate at the output. In accord with further embodiments, a pump and motor assembly is mounted to and generally surrounded by a liquid tank. The pump and motor assembly may include a pair of fixed ratio outputs driven from a common motor, or may include a single variable output pump either slaved to a master pump or controlled through a timed bypass valve to control output flow rate.

Abstract: An absolute proportioning pumping system includes an electric motor assembly powering a first pump at a first flow rate and powering a second pump at a second flow rate. A proportioned fluid output includes a first fluid pumped by the first pump and a second fluid pumped by the second pump. The pumping system provides a desired ratio of the first fluid to the second fluid at the proportioned fluid output, relatively independently of pressure and flow rate at the output. In accord with further embodiments, a pump and motor assembly is mounted to and generally surrounded by a liquid tank. The pump and motor assembly may include a pair of fixed ratio outputs driven from a common motor, or may include a single variable output pump either slaved to a master pump or controlled through a timed bypass valve to control output flow rate.

Abstract: An absolute proportioning pumping system includes an electric motor assembly powering a first pump at a first flow rate and powering a second pump at a second flow rate. A proportioned fluid output includes a first fluid pumped by the first pump and a second fluid pumped by the second pump. The pumping system provides a desired ratio of the first fluid to the second fluid at the proportioned fluid output, relatively independently of pressure and flow rate at the output. In accord with further embodiments, a pump and motor assembly is mounted to and generally surrounded by a liquid tank. The pump and motor assembly may include a pair of fixed ratio outputs driven from a common motor, or may include a single variable output pump either slaved to a master pump or controlled through a timed bypass valve to control output flow rate.

Abstract: An absolute proportioning pumping system includes an electric motor assembly powering a first pump at a first flow rate and powering a second pump at a second flow rate. A proportioned fluid output includes a first fluid pumped by the first pump and a second fluid pumped by the second pump. The pumping system provides a desired ratio of the first fluid to the second fluid at the proportioned fluid output, relatively independently of pressure and flow rate at the output. In accord with further embodiments, a pump and motor assembly is mounted to and generally surrounded by a liquid tank. The pump and motor assembly may include a pair of fixed ratio outputs driven from a common motor, or may include a single variable output pump either slaved to a master pump or controlled through a timed bypass valve to control output flow rate.

Abstract: A fluid pumping system that includes a motor and a pump, wherein an output shaft of the motor is directly coupled to an input shaft of the pump. This coupling between the output shaft of the motor and the input shaft of the pump may be the primary mechanism for coupling the motor to the pump. Such a configuration may be called a “floating pump mount”, because the pump is primarily coupled to the motor via the shaft connection. As a result of this connection, the output shaft of the motor may be naturally “aligned” with the input shaft of the pump. To help prevent the pump from freely rotating with the output shaft of the motor during operation, a rotational stop mechanism may be provided. The rotational stop mechanism may include at least one resilient member for absorbing or substantially absorbing at least some of any relative movement between the pump and the motor.

Abstract: A precision pumping system is disclosed. The pumping system includes an electric motor assembly powering a first drive shaft driving a first pump at a first flow rate and powering a second drive shaft driving a second pump at a second flow rate. A proportioned fluid output includes a first fluid pumped by the first pump and a second fluid pumped by the second pump. The pumping system provides a desired ratio of the first fluid to the second fluid at the proportioned fluid output, relatively independently of pressure and flow rate at the output.

Abstract: Reverse osmosis (RO) systems having efficiency enhancing features are disclosed. Included are RO systems having a RO module and a pumping system. A feed fluid line can introduce feed fluid into the pumping system, and the pumping system can increase the pressure of the feed and pass the pressurized feed to the RO module. Such RO systems can also have a recycle stream leading from a concentrate side of the RO module to the pumping system and a purified stream leading from a purified side of the RO module. In some cases, the pumping system can boost the pressure of both the feed fluid and the recycle stream, and the boosted fluids can be fed into the RO module. The pumping system can have first and second pumping chambers for the feed fluid and the recycled concentrate. These pumping chambers can be separate pumps, or they can be referred to as a single pumping system, for example a double-acting simplex plunger pump.

Abstract: A coolant system for a machining center includes a cutting tool selectively engageable with a work-piece and includes a pump for supplying a flow of coolant to the cutting tool, a motor drivingly engaging the pump, a pressure transducer measuring the pressure of the coolant being supplied to the cutting tool and a controller in communication with the pressure transducer and the motor. The controller compares the pressure measured to a predetermined target pressure and varies the speed of the motor to minimize deviation of the measured pressure from the target pressure.

Abstract: A coolant system for a machining center includes a cutting tool selectively engageable with a work-piece and includes a pump for supplying a flow of coolant to the cutting tool, a motor drivingly engaging the pump, a pressure transducer measuring the pressure of the coolant being supplied to the cutting tool and a controller in communication with the pressure transducer and the motor. The controller compares the pressure measured to a predetermined target pressure and varies the speed of the motor to minimize deviation of the measured pressure from the target pressure.

Abstract: A water mist cooling system including a supply of water at a supply outlet. A plurality of misting nozzles are serially connected by hollow tubing means to form a line having two ends. A pump has an inlet connected to the supply outlet, and an outlet connected to a first of two ends of a line of nozzles. The pump is controlled whereby water is pumped by the pump at a preselected pressure through said hollow tubing means to the misting nozzles and thence exiting the nozzles as water mist to the atmosphere. Pressure regulator means is connected to the other of said ends of the line of misting nozzles to provide a line flushing function.

Abstract: An elongated strap useful for bundling hoses, cables, extensions cords, and the like. One end of the strap is formed into an integral handle which the user may grasp to carry the bundled item. The handle portion also contains a boss with a through hole useful for hanging the bundled item over a screw or nail. The strap is locked around the item to be bundled by a two stage latch. While this latch provided substantial holding strength, it may also be unfastened and refastened a number of times without wearing out.

Abstract: A bi-directional fluid valve apparatus comprising a valve member adapted to co-act with an annular shoulder at the end of a fluid bore, the valve member having two axial ends. A flat surface on a first end having a diameter greater than that of the shoulder is positioned with the flat surface abutting the axial end surface of the shoulder. At least two axially extending and circumferentially spaced apart ribs are on the second axial end thereof, each of the ribs terminating in an end surface. The ribs are positioned so that the end surfaces are in axial alignment with, and spaced a preselected distance from, the axial end surface of the shoulder. Hollow coil spring means are positioned within the recesses in register with the bores, and having a first end engaging one of the shoulders, and a second end engaging the at least three circumferentially spaced apart ribs and the second axial end of the valve member.

Abstract: A bi-directional fluid valve apparatus comprising a valve member adapted to co-act with an annular shoulder at the end of a fluid bore, the valve member having two axial ends. A flat surface on a first end having a diameter greater than that of the shoulder is positioned with the flat surface abutting the axial end surface of the shoulder. At least two axially extending and circumferentially spaced apart ribs are on the second axial end thereof, each of the ribs terminating in an end surface. The ribs are positioned so that the end surfaces are in axial alignment with, and spaced a preselected distance from, the axial end surface of the shoulder. Hollow coil spring means are positioned within the recesses in register with the bores, and having a first end engaging one of the shoulders, and a second end engaging the at least three circumferentially spaced apart ribs and the second axial end of the valve member.