Abstract: The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.

Abstract: The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.

Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein domain I and domain II hinge region from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.

Abstract: The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of influenza virus infections. In particular, these antibodies may neutralize or limit the replication of H1N1 influenza virus. Also disclosed are improved methods for producing such monoclonal antibodies.

Abstract: The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of influenza virus infections. In particular, these antibodies may neutralize or limit the replication of influenza virus. Also disclosed are improved methods for producing such monoclonal antibodies, including novel immunogens for use in vaccination and production of protective immune responses.

Abstract: In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Human monoclonal antibodies and fragments thereof which bind and neutralize respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also disclosed are diagnostic and immunotherapeutic methods of using the monoclonal antibodies as well as cell lines producing the monoclonal antibodies.

Abstract: The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.

Abstract: A teaching and learning game for players to learn the sequence of letters in the alphabet. In a preferred embodiment, a set of fifty cards comprising two groups of twenty-five cards each are provided. The first side of one group has marked thereon a respective letter of the alphabet and first indicia to indicate the succeeding letter of the alphabet such that the players are directed to identify the letter of the alphabet which succeeds the letter marked on the first side of the card. The first side of the second group has marked thereon a respective letter of the alphabet and second indicia to indicate the preceding letter of the alphabet such that players are directed to identify the letter of the alphabet which precedes the letter marked on the second side of the card. The second side of the card has third indicia marked thereon to direct the players and to further teach the players the relation between the third indicia and the letters of the alphabet. A set of instructions is also provided.

Abstract: A teaching and learning game for players to learn the sequence of letters in the alphabet. In a preferred embodiment, a set of blocks has a different letter of the alphabet marked on each side of a respective block and further has marked on two sides of the block, first indicia means to indicate the preceding letter, and has marked on two other sides of the block second indicia means to indicate the succeeding letters. Another preferred embodiment includes a set of twenty-six cards having the letters of the alphabet marked in alphabetical sequence on the sides of the cards. Further, one side of each card is marked with first indicia means to indicate the preceding letter and the other side of each card is marked with second indicia means to indicate the succeeding letter. Point scores are awarded to players correctly identifying the preceding or succeeding letter of the alphabet. Selected cards are further marked with scoring indicators to award bonus points to the players.