Patents by Inventor James E. Flaherty
James E. Flaherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957577Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.Type: GrantFiled: March 31, 2020Date of Patent: April 16, 2024Assignee: 4C Medical Technologies, Inc.Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
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Publication number: 20200276013Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.Type: ApplicationFiled: May 18, 2020Publication date: September 3, 2020Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
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Publication number: 20200222179Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.Type: ApplicationFiled: March 31, 2020Publication date: July 16, 2020Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
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Patent number: 10653523Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.Type: GrantFiled: January 18, 2018Date of Patent: May 19, 2020Assignee: 4C Medical Technologies, Inc.Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
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Publication number: 20180200049Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.Type: ApplicationFiled: January 18, 2018Publication date: July 19, 2018Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
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Publication number: 20120208292Abstract: A device including a shallow chamber for analyzing a target analyte in a body fluid using the signal generated by fluorescent detector molecules specific for the target analyte and attenuating the signal emitted by fluorescent detector molecules non-specifically bound to the surfaces of the chamber by a signal attenuating dye; and method thereof.Type: ApplicationFiled: December 15, 2011Publication date: August 16, 2012Inventors: William Lewis, James E. Flaherty, Eugene K. Achter, Dirk Kurowski
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Publication number: 20100063921Abstract: Participants to the commercial mortgage backed securities (CMBS) market enter data unique to their property via a web-based application that applies underwriting assumptions and/or methods of transforming income and expense information into a format acceptable to the CMBS industry. The resulting data set is suitable for analysis by lenders, third party credit rating companies, and investors thus standardizing and simplifying the process of obtaining a loan, the need for lenders to perform standardized underwriting analysis, and the transfer of this analysis to both the rating agencies and the investors. The disclosed methods and procedures greatly simplify how loans enter into the CMBS market and how investors analyze the performance of loans already in the CMBS market.Type: ApplicationFiled: September 10, 2008Publication date: March 11, 2010Inventor: James E. Flaherty
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Patent number: 5728267Abstract: A concentrator for concentrating a sample solution including molecules in solution which are larger than their molecular weight cutoff of a membrane in the concentrator. The concentrator has a sample reservoir which includes a bottom floor having an annular central wall surrounding a central opening. A membrane is held on a membrane support member positioned below the sample reservoir and a filtrate vial is held below the membrane to collect liquid which is passed through the membrane. A retentate vial is held over the top of the reservoir and after the sample has been concentrated the filtrate vial is removed and the remaining part of the assembly inverted. The assembly is then replaced in the centrifuge and spun to transfer the concentrated sample into the retentate vial. The membrane support member is made from spokes with open spaces between the spokes.Type: GrantFiled: November 15, 1994Date of Patent: March 17, 1998Inventor: James E. Flaherty
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Patent number: 5711868Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: January 27, 1998Assignee: Chiron Diagnostics CorporatiionInventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5601694Abstract: A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: July 27, 1995Date of Patent: February 11, 1997Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5595646Abstract: A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conductive strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 .mu.m. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.Type: GrantFiled: August 24, 1995Date of Patent: January 21, 1997Assignee: Ciba Corning Diagnostics Corp.Inventors: Joseph S. Foos, Peter G. Edelman, James E. Flaherty, Joseph Berger
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Patent number: 5582698Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: July 27, 1995Date of Patent: December 10, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason
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Patent number: 5573647Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: November 12, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
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Patent number: 5529676Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: June 25, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Robert B. Green, Steven C. Lepke, Richard W. Mason, Robert R. McCaffrey, John A. Zalenski
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Patent number: 5518601Abstract: A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conductive strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 N.L. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.Type: GrantFiled: August 24, 1995Date of Patent: May 21, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Joseph S. Foos, Peter G. Edelman, James E. Flaherty, Joseph Berger
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Patent number: 5503719Abstract: A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conductive strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 .mu.l. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.Type: GrantFiled: March 9, 1994Date of Patent: April 2, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Joseph S. Foos, Peter G. Edelman, James E. Flaherty, Joseph Berger
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Patent number: 5494562Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: June 27, 1994Date of Patent: February 27, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: D367235Type: GrantFiled: June 27, 1994Date of Patent: February 20, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty
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Patent number: D371749Type: GrantFiled: July 19, 1995Date of Patent: July 16, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty
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Patent number: D372877Type: GrantFiled: July 19, 1995Date of Patent: August 20, 1996Assignee: Ciba Corning Diagnostics Corp.Inventors: Paul A. D'Orazio, James E. Flaherty