Patents by Inventor James E. Flor

James E. Flor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermal isomer of difficidin and thermal isomer of oxydifficidin antibacterials
    Patent number: 4816448
    Abstract: The present invention relates to novel antibacterial compounds referred to herein generally as a thermal isomer of difficidin and thermal isomer of oxydifficidin. Also disclosed is process for preparing, isolating and purifying said compounds.
    Type: Grant
    Filed: February 5, 1987
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth E. Wilson, James E. Flor, Otto D. Hensens, Jerrold M. Liesch, Reamer, Robert A.
  • Process for the preparation of difficidin and derivative antibacterials
    Patent number: 4681846
    Abstract: Process for the preparation of difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: May 6, 1985
    Date of Patent: July 21, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth E. Wilson, Richard L. Monaghan, Cheryl DeRiso, Sheldon B. Zimmerman, Otto D. Hensens, James E. Flor, Sagrario M. Del Val, Maria I. M. Fernandez
  • Difficidin and derivative antibacterials
    Patent number: 4545991
    Abstract: Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: October 8, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Sheldon B. Zimmerman, Kenneth E. Wilson, Richard L. Monaghan, Sagrario M. Del Val, Maria I. M. Fernandez, Otto D. Hensens, James E. Flor, Cheryl Deriso
  • Process for producing Tunicamycin
    Patent number: 4330624
    Abstract: The antibiotic Tunicamycin is produced by fermenting a Tunicamycin-producing strain of Streptomyces (Streptomyces griseus ATCC 31591) under controlled conditions in a suitable nutrient medium and isolating the antibiotic so produced from the fermentation medium.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: May 18, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Enrique Tejera, Sara A. Currie, James E. Flor, Richard L. Monaghan
  • Process for producing A73A, a new Efrotomycin-like antibiotic in fermentation broth
    Patent number: 4304859
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: December 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa
  • Discovery of A73A, a new efrotomycin-like antibiotic in fermentation broth
    Patent number: 4262002
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa