Patents by Inventor James E. Gern

James E. Gern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of propagating rhinovirus C in previously unsusceptible cell lines
    Patent number: 10280405
    Abstract: The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 7, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James E. Gern, Yury A. Bochkov, Ann C. Palmenberg
  • Adapted rhinovirus C
    Patent number: 10253300
    Abstract: A mutated rhinovirus C, methods of creating and methods of propagating thereof, wherein the mutated rhinovirus shows enhanced virus yields after infection and induced visible cytopathic effect.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: April 9, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Yury A. Bochkov, James E. Gern, Ann C. Palmenberg, Kelly E. Watters
  • Methods Of Propagating Rhinovirus C In Previously Unsusceptible Cell Lines
    Publication number: 20190055521
    Abstract: The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.
    Type: Application
    Filed: March 6, 2018
    Publication date: February 21, 2019
    Inventors: James E. Gern, Yury A. Bochkov, Ann C. Palmenberg
  • Methods of propagating rhinovirus C in previously unsusceptible cell lines
    Patent number: 9938507
    Abstract: The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: April 10, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James E. Gern, Yury A. Bochkov, Ann C. Palmenberg
  • Methods Of Propagating Rhinovirus C In Previously Unsusceptible Cell Lines
    Publication number: 20170082609
    Abstract: The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.
    Type: Application
    Filed: August 26, 2015
    Publication date: March 23, 2017
    Inventors: James E. Gern, Yury A. Bochkov, Ann C. Palmenberg
  • ADAPTED RHINOVIRUS C
    Publication number: 20170044503
    Abstract: A mutated rhinovirus C, methods of creating and methods of propagating thereof, wherein the mutated rhinovirus shows enhanced virus yields after infection and induced visible cytopathic effect.
    Type: Application
    Filed: August 10, 2016
    Publication date: February 16, 2017
    Inventors: Yury A. Bochkov, James E. Gern, Ann C. Palmenberg, Kelly E. Watters
  • Acidic buffered nasal spray
    Patent number: 6187332
    Abstract: Disclosed herein are buffered flowable nasal sprays having a pH of between 4.0 and 5.0. They are primarily water and a citrate (or citrate/phosphate) buffer. They may also contain sodium chloride, thickeners, and/or preservatives. The preparations are able to maintain the aforesaid pH under conditions simulating a runny nose. Methods of using these preparations to inhibit the spread of rhinovirus and/or diseases caused by rhinovirus are also disclosed.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: February 13, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James E. Gern, Anne G. Mosser