Patents by Inventor James E. Hansen

James E. Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190307883
    Abstract: Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A sub-set of autoantibodies having nucleolytic activity are capable of nuclear penetration. These antibodies can be used as therapeutic agents targeted towards DNA repair-deficient malignancies.
    Type: Application
    Filed: February 20, 2019
    Publication date: October 10, 2019
    Inventors: James E. Hansen, Richard H. Weisbart, Philip W. Noble
  • Patent number: 10410452
    Abstract: A circuit assembly comprising a sealed interface is configured to isolate one or more electrical components. The assembly comprises a circuit board comprising a substrate and a cover comprising a polycarbonate material in connection with the substrate. The assembly further comprises an adhesive seal disposed around a perimeter surface of the cover. The adhesive seal comprises a UV curable adhesive having a chemical composition. The assembly further comprises a polyamide over-molded coating enclosing at least a portion of the circuit board and covering the adhesive seal.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: September 10, 2019
    Assignee: GENTEX CORPORATION
    Inventors: Joel A. Stray, Dennis E. Vilcans, Sinisa Likic, Derek S. Blaskowski, Thomas S. Wright, Jonathan M. Hansen, James S. Sheline
  • Publication number: 20190184178
    Abstract: Implantable medical devices including interconnections having strain-relief structure. The interconnections can take the form of flexible circuits. Strain relief gaps and shapes are integrated in the interconnections to relieve forces in each of three dimensions. In some examples, the region of an interconnection which couples with a component of the implantable medical device is separated by a strain relief gap from a connection to a second component and/or a location where the flex bends around a corner.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Applicant: CARDIAC PACEMAKERS, INC.
    Inventors: Jean M. Bobgan, Moira B. Sweeney, James E. Blood, Robert A. Jones, John E. Hansen, Keith R. Maile
  • Publication number: 20190177754
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 13, 2019
    Inventors: James Casey LIPPMEIER, Joseph W. PFEIFER, III, Jon Milton HANSEN, Kirk E. APT, William Robert BARCLAY, Paul Warren BEHRENS, David Christian MARTIN
  • Patent number: 10315944
    Abstract: The present invention relates to a method of dewatering an aqueous mineral suspension comprising introducing into the suspension a flocculating system comprising a poly(ethylene oxide) copolymer, in particular a copolymer of ethylene oxide and one or more silane- or siloxane-functionalized glycidyl ether monomer. Said poly(ethylene oxide) copolymers are useful for the treatment of suspensions of particulate material, especially waste mineral slurries. The invention is particularly suitable for the treatment of tailings and other waste material resulting from mineral processing, in particular, the processing of oil sands tailings.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: June 11, 2019
    Assignee: Dow Global Technologies LLC
    Inventors: Cole A. Witham, Matthew J. Hansen, James E. Hitt, Carol E. Mohler, Michael K. Poindexter
  • Patent number: 10308965
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 4, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: James Casey Lippmeier, Joseph W. Pfeifer, III, Jon Milton Hansen, III, Kirk E. Apt, William Robert Barclay, Paul Warren Behrens, David Christian Martin
  • Publication number: 20190150487
    Abstract: A stabilized flour, such as stabilized whole grain wheat flour, exhibiting unexpectedly superior extended shelf life and superior biscuit baking functionality, may be produced with or without heating to inhibit lipase by subjecting whole grains or a bran and germ fraction or component to treatment with a lipase inhibitor, such as an acid or green tea extract. Treatment with the lipase inhibitor may be performed during tempering of the whole grains or berries or during hydration of the bran and germ fraction or component.
    Type: Application
    Filed: January 23, 2019
    Publication date: May 23, 2019
    Inventors: Bin Zhao, Ning Zhou, Timothy S. Hansen, Michael A. Duffin, Domenico R. Cassone, Diane L. Gannon, Lynn C. Haynes, James M. Manns, Jeanny E. Zimeri, Peter Worfolk, Anthony Pracek
  • Patent number: 10238742
    Abstract: Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A sub-set of autoantibodies having nucleolytic activity are capable of nuclear penetration. These antibodies can be used as therapeutic agents targeted towards DNA repair-deficient malignancies.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: March 26, 2019
    Assignees: Yale University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: James E. Hansen, Richard H. Weisbart, Philip W. Noble
  • Patent number: 10040867
    Abstract: It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: August 7, 2018
    Assignees: Yale University, The United States of America, as Represented by The Department of Veterans Affairs
    Inventors: James E. Hansen, Richard H. Weisbart, Melissa Young, Philip W. Noble
  • Publication number: 20180044409
    Abstract: The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78 or portion thereof, and optionally, the 3E10 Fv comprising an amino acid sequence AGIH at its amino terminus.
    Type: Application
    Filed: July 14, 2017
    Publication date: February 15, 2018
    Inventors: Richard H. Weisbart, Robert N. Nishimura, James E. Hansen
  • Publication number: 20170334981
    Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
    Type: Application
    Filed: June 6, 2017
    Publication date: November 23, 2017
    Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
  • Publication number: 20170291961
    Abstract: Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the variant scFv has one or more insertions, deletions, or substitutions relative to a corresponding 3E10 scFv, and wherein the molecule can bind, preferably specifically bind, to the epitope of 3E10. Methods of using the antigen binding molecules for treating cancer and viral infections or preventing viral infections are also provided.
    Type: Application
    Filed: August 27, 2015
    Publication date: October 12, 2017
    Inventors: James E. Hansen, Richard H. Weisbart, Philip W. Noble
  • Patent number: 9701740
    Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: July 11, 2017
    Assignees: YALE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The United States of America represented by the Department of Veterans Affairs
    Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
  • Publication number: 20170073429
    Abstract: It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.
    Type: Application
    Filed: March 4, 2015
    Publication date: March 16, 2017
    Inventors: James E. Hansen, Richard H. Weisbart, Melissa Young, Philip W. Noble
  • Publication number: 20150376279
    Abstract: Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A sub-set of autoantibodies having nucleolytic activity are capable of nuclear penetration. These antibodies can be used as therapeutic agents targeted towards DNA repair-deficient malignancies.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 31, 2015
    Inventors: James E. Hansen, Richard H. Weisbart, Philip W. Noble
  • Publication number: 20140050723
    Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
    Type: Application
    Filed: April 2, 2012
    Publication date: February 20, 2014
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YALE UNIVERSITY
    Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
  • Publication number: 20110054613
    Abstract: A spinal implant includes a tapering box-shaped block made of a bone material; and at least one buttress ridge disposed on at least one surface of the tapering box-shaped block. A spinal implant bolt includes a shaft with a cylindrical body, the shaft having a leading end and a trailing end, wherein the trailing end has at least one slot for receiving a screw driver; and a buttress thread dispose on the shaft in a spiral configuration, wherein the buttress thread has a leading flank facing the leading end of the shaft and a trailing flank facing the trailing end of the shaft, the leading flank forms a smaller angle with a longitudinal axis of the shaft than an angle formed between the trailing flank and the longitudinal axis of the shaft, wherein the spinal implant bolt is made of a bone material.
    Type: Application
    Filed: August 26, 2009
    Publication date: March 3, 2011
    Applicant: MURREN, LLC
    Inventor: James E. Hansen
  • Patent number: 7501836
    Abstract: An apparatus for determining capacitance variation in an integrated circuit, includes at least two capacitances, a stimulus provided to the at least two capacitances, and a first logic element coupled to the stimulus and the at least two capacitances, the first logic element configured to switch state upon a state transition of the stimulus when the at least two capacitances differ in value by a predetermined amount.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: March 10, 2009
    Assignee: Avago Technologies Enterprise IP (Singapore) Pte. Ltd.
    Inventors: James E. Hansen, Robert H. Hansen, Gregory J. Milburn
  • Publication number: 20090023973
    Abstract: A process for melting material to be treated includes placing material to be treated in a container that may include an insulating lining, heating the material to be treated and melting the material to be treated, preferably allowing the melted material to cool to form a vitrified and/or crystalline mass, and disposing of the mass. The mass is either disposed while contained in container or removed from container after cooling and disposed. Heat loss and melt-surface disruptions can be minimized with an engineered overburden material, which covers at least a portion of an exposed surface of the material to be treated.
    Type: Application
    Filed: January 27, 2006
    Publication date: January 22, 2009
    Inventors: Patrick S. Lowery, Leo E. Thompson, Craig Timmerman, Jack L. McElroy, Brett E. Campbell, James E. Hansen
  • Publication number: 20080128271
    Abstract: A process for melting material to be treated includes placing material to be treated in a container that may include an insulating lining, heating the material to be treated and melting the material to be treated, preferably allowing the melted material to cool to form a vitrified and/or crystalline mass, and disposing of the mass. The mass is either disposed while contained in container or removed from container after cooling and disposed. The time required for startup of the melting procedure can be reduced by utilizing a plurality of electrodes and multiple starter paths, at least one of which is horizontally-oriented and positioned in a deeper region of the melt container.
    Type: Application
    Filed: January 27, 2006
    Publication date: June 5, 2008
    Applicant: GEOSAFE CORPORATION
    Inventors: Patrick S. Lowery, James E. Hansen