Patents by Inventor James E. Heikes

James E. Heikes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby
    Patent number: 4873356
    Abstract: A method is provided for preparing phosphinic acid compounds, which are useful in preparing certain angiotensin converting enzyme inhibitors, which have the formula ##STR1## wherein R.sub.1 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl;R.sub.2 is hydrogen, lower alkyl or arylalkyl;X is hydrogen, lower alkyl or phenyl;Y is hydrogen, lower alkyl, phenyl or alkoxy, or together X and Y are --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.dbd.CH--, or ##STR2## and n is 0 or 1including salts thereof and stereoisomers thereof, which method includes the steps of reacting a phosphinic acid ester of the structure ##STR3## wherein R.sub.
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 10, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Donald S. Karanewsky, John K. Thottathil, James E. Heikes, John A. Grosso
  • 7-Oxabicycloheptane prostaglandin intermediates
    Patent number: 4503241
    Abstract: 7-Oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided. The final products are used in the treatment of thrombolytic disease.
    Type: Grant
    Filed: May 13, 1983
    Date of Patent: March 5, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes
  • 7-Oxabicycloheptaine prostaglandin intermediates and method for preparing same
    Patent number: 4500723
    Abstract: 7-Oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided.
    Type: Grant
    Filed: May 13, 1983
    Date of Patent: February 19, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes
  • 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same
    Patent number: 4499292
    Abstract: Optically active 7-oxabicyclopheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided.
    Type: Grant
    Filed: May 13, 1983
    Date of Patent: February 12, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes
  • 1,3-Benzodithiolanes
    Patent number: 4107175
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; R.sub.2 is carboxyl or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.
    Type: Grant
    Filed: December 17, 1976
    Date of Patent: August 15, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes
  • 1,3-Benzodithiolanes
    Patent number: 4104467
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; and R.sub.2 is an amino group, a 5- or 6-membered heterocyclic group, a 3-indolyl group, carboxyl, or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.
    Type: Grant
    Filed: July 16, 1976
    Date of Patent: August 1, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter W. Sprague, James E. Heikes