Patents by Inventor James E. HUCKLE

James E. HUCKLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mcl-1 inhibitor formulations
    Patent number: 12643913
    Abstract: Provided herein are solid dispersions comprising AMG 397, methods of preparing the solid dispersion, and pharmaceutical formulations comprising AMG 397.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: June 2, 2026
    Assignee: AMGEN INC.
    Inventors: James E. Huckle, Markian M. Stec, Tian Wu, Darren L Reid, Fernando A. Alvarez-Nunez, Sean P. Brown
  • Crystalline Salt and Solvate Forms Of Murizatoclax (AMG 397)
    Publication number: 20250122224
    Abstract: Disclosed herein are salt and solvate forms of (4S,7aR,9aR,10R,11E,14S,15R)-6?-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3?,4?,7a,8,9,9a,10,13,14,15-decahydro-2?H,3H,5H-spiro[1,19-etheno-16,16-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadlazacyclohexadecine-4,1 naphthalene]-16,16,18 (7H,17H)-trione (AMG 397): (AMG 397), such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.
    Type: Application
    Filed: February 3, 2023
    Publication date: April 17, 2025
    Inventors: Ron C. Kelly, Mary Chaves, Jing Teng, Stephan Parent, Van Luu, Robert P. Farrell, James E. Huckle, Michal Achmatowicz, Tian Wu, Darren Leonard Reid, Lingyun Xiao
  • Crystalline Forms Of An MCL-1 Inhibitor
    Publication number: 20250115622
    Abstract: Disclosed herein are crystalline forms of (4S,7aR,9aR,10R,11E,14S,15R)-6?-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3?,4?,7a,8,9,9a,10,13,14,15-decahydro-2?H,3H,5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1?-naphthalene]-16,16,18(7H,17H)-trione (AMG 397): (AMG 397), hydrates, and solvates thereof. Also disclosed are methods of making the crystalline forms, and methods of treating diseases and disorders with the crystalline forms.
    Type: Application
    Filed: February 3, 2023
    Publication date: April 10, 2025
    Inventors: Ron C. Kelly, Mary Chaves, Jing Teng, Stephan Parent, Markian Stec, Van Luu, Robert P. Farrell, James E. Huckle, Michal Achmatowicz, Tian Wu, Darren Leonard Reid, Lingyun Xiao
  • MCL-1 INHIBITOR FORMULATIONS
    Publication number: 20230312606
    Abstract: Provided herein are solid dispersions comprising AMG 397, methods of preparing the solid dispersion, and pharmaceutical formulations comprising AMG 397.
    Type: Application
    Filed: August 24, 2021
    Publication date: October 5, 2023
    Applicant: AMGEN INC.
    Inventors: JAMES E. HUCKLE, MARKIAN M. STEC, TIAN WU, DARREN L. REID, FERNANDO A. ALVAREZ-NUNEZ, SEAN P. BROWN
  • METHYLATION OF MCL-1 COMPOUNDS
    Publication number: 20230117777
    Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).
    Type: Application
    Filed: March 30, 2021
    Publication date: April 20, 2023
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, Sheng CUI, Tsang-Lin HWANG, Neil Fred LANGILLE, Janine K. TOM, James E. HUCKLE, Markian STEC, Tian WU, Sean P. BROWN