Abstract: The instant disclosure is generally directed to low viscosity, low volatility lubricating compositions. The lubricating composition of the instant disclosure includes an oil of lubricating viscosity that contains a lubricating base oil and a hydrocarbon oil. The hydrocarbon oil makes up least 20 wt % of the oil of lubricating viscosity and has a kinematic viscosity of less than 3.7 c St at 100° C. and a NOACK volatility (measured by ASTM D5800) of less than 25 wt %. The lubricant composition further includes a polyalkenyl succinimide dispersant, and, optionally, other formulation additives. The lubricating compositions have been shown to increase fuel economy in internal combustion engines.

Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: Described herein is the use of bisamidoximes compounds for the treatment of HAT malfunction related pathologies.

Abstract: Described herein is the use of bisamidoximes compounds for the treatment of HAT malfunction related pathologies.

Abstract: Disclosed are methods and devices for endocardial left atrial appendage management (LAAM) by inversion and excision. The methods may comprise inserting an inverter apparatus into an interior cavity of the left atrial appendage (LAA) of a subject and inverting the LAA, closing the base portion of the inverted LAA with the one or more closure devices, separating the inverted LAA from the left atrium with a separation apparatus positioned at the base portion of the inverted LAA adjacent to the one or more closure devices, and removing the separated LAA from the subject.

Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. A system includes an introducer tool including a dilator portion, a carrier portion and a release mechanism, the dilator portion selectively engageable with the carrier portion. The system further includes a lead including a lead body and an electrode structure, the electrode structure including an active side with an electrode disposed thereon, and an inactive side with an element disposed thereon. The introducer tool is configured to be temporarily inserted into a patient over a guidewire, and a portion of the release mechanism is selectively engageable with the element of the electrode structure to retain the electrode structure to the introducer tool.

Abstract: In various embodiments, methods and systems for optimizing allocation of multi-priority service instances are provided. In embodiments, a quality metric associated with each candidate node to which a service instance could be allocated is determined. An eviction cost or a survival metric associated with at least a portion of the candidate nodes to which the service instance could be allocated are determined. The eviction costs generally indicate a cost to evict a service instance from a corresponding node such that another service instance can be allocated to that node. At least a portion of the quality metrics and either the eviction costs or the survival metrics are used to select a node from the candidate nodes to which to allocate the service instance.

Abstract: Described herein is the use of bisamidoximes compounds for the treatment of HAT malfunction related pathologies.

Abstract: Described herein is the use of bisamidoximes compounds for the treatment of cancer. In preferred embodiments, combinations of two or more bisamidoximes or combinations of a bisamidoxime and another anti-cancer agent were found to be effective against various types of cancer cells.

Abstract: In various embodiments, methods and systems for optimizing allocation of multi-priority service instances are provided. In embodiments, a quality metric associated with each candidate node to which a service instance could be allocated is determined. An eviction cost or a survival metric associated with at least a portion of the candidate nodes to which the service instance could be allocated are determined. The eviction costs generally indicate a cost to evict a service instance from a corresponding node such that another service instance can be allocated to that node. At least a portion of the quality metrics and either the eviction costs or the survival metrics are used to select a node from the candidate nodes to which to allocate the service instance.

Abstract: Technologies for managing fault recovery in a cloud computing environment may be used after faults of various sizes, including faults which put total functioning capacity below subscribed capacity. Computing services have repair priorities. A fault recovery manager selects a higher priority service whose capacity is below a minimum availability, and chooses a lower priority service still above its minimal availability, and reassigns capacity from the lower priority service to the higher priority service without depriving the lower priority service of operability. Capacity reassignment continues at least until the higher priority service is at or above minimal availability, or the lower priority service is at minimal availability. Lower priority services may also be terminated entirely to free up resources for higher priority services. New deployments may be prevented until all services are at or above minimal availability. Spare capacity may be reserved against demand fluctuations or further faults.

Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: In various embodiments, methods and systems for optimizing allocation of dynamic resources are provided. A user service request resource instance is received at an allocator. The user service request resource instance is based on a dynamic resource protocol that supports generating and communicating resource instances between components in a resource allocation platform. The dynamic resource protocol also defines a set of rules for translating and representing resources as logical resource types and logical units. At a node, a node resource instance is generated and communicated, based on the dynamic resource protocol, from the node to the allocator. The node resource instance specifically comprises a resource interaction matrix that indicates dependencies between resource types. A resource allocation instance is generated at the allocator for the user service request resource instance.

Abstract: In various embodiments, methods and systems for optimizing allocation of multi-priority service instances are provided. In embodiments, a packing quality metric associated with each candidate node to which a service instance could be allocated are determined. An eviction cost associated with at least a portion of the candidate nodes to which the service instance could be allocated are determined. The eviction costs generally indicate a cost to evict a service instance from a corresponding node such that another service instance can be allocated to that node. At least a portion of the packing quality metrics and the eviction costs are used to select a node from the candidate nodes to which to allocate the service instance.

Abstract: Systems and methods are taught for providing customers of a cloud computing service to control when updates affect the services provided to the customers. Because multiple customers share the cloud's infrastructure, each customer may have conflicting preferences for when an update and associated downtime occurs. Preventing and resolving conflicts between the preferences of multiple customers while providing them with input for scheduling a planned update may reduce the inconvenience posed by updates. Additionally, the schedule for the update may be transmitted to customers so that they can prepare for the downtime of services associated with the update.

Abstract: Described herein is the use of bisamidoximes compounds for the treatment of cancer. In preferred embodiments, combinations of two or more bisamidoximes or combinations of a bisamidoxime and another anti-cancer agent were found to be effective against various types of cancer cells.