Patents by Inventor James E. McGrath
James E. McGrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931739Abstract: Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.Type: GrantFiled: August 16, 2018Date of Patent: March 19, 2024Assignees: SiMPore Inc., University of RochesterInventors: James A. Roussie, James L. McGrath, Richard E. Waugh, Kilean S. Lucas, Joshua J. Miller
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Patent number: 10188992Abstract: Disclosed are polybenzimidazoles containing sulfonyl groups. The polymers can be synthesized in Eaton's reagent from 3,3?,4,4?-tetraaminodiphenylsulfone, which itself can be synthesized from 4,4?-dichlorodiphenylsulfone. Methods of synthesizing the polymers are disclosed. The disclosed polymers can be used for high temperature H2/CO2 separation membranes and other uses.Type: GrantFiled: September 19, 2016Date of Patent: January 29, 2019Assignees: Board of Regents, The University of Texas System, Virginia Tech Intellectual Properties, Inc.Inventors: James E. McGrath, Judy S. Riffle, Benny D. Freeman
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Publication number: 20180008753Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.Type: ApplicationFiled: September 22, 2017Publication date: January 11, 2018Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
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Patent number: 9782523Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.Type: GrantFiled: May 5, 2011Date of Patent: October 10, 2017Assignee: Reva Medical, Inc.Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
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Publication number: 20170081477Abstract: Disclosed are polybenzimidazoles containing sulfonyl groups. The polymers can be synthesized in Eaton's reagent from 3,3?,4,4?-tetraaminodiphenylsulfone, which itself can be synthesized from 4,4?-dichlorodiphenylsulfone. Methods of synthesizing the polymers are disclosed. The disclosed polymers can be used for high temperature H2/CO2 separation membranes and other uses.Type: ApplicationFiled: September 19, 2016Publication date: March 23, 2017Inventors: James E. McGrath, Judy S. Riffle, Benny D. Freeman
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Patent number: 8703113Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.Type: GrantFiled: January 18, 2006Date of Patent: April 22, 2014Assignee: REVA Medical Inc.Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
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Patent number: 8551511Abstract: A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.Type: GrantFiled: October 11, 2009Date of Patent: October 8, 2013Assignee: Rutgers, The State University of New JerseyInventors: Don K. Brandom, Durgadas Bolikal, Lioubov Kabalnova, James E. McGrath, Joachim Kohn
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Patent number: 8383763Abstract: Sulfonated polymers are made by the direct polymerization of a sulfonated monomer to form the sulfonated polymers. The types of sulfonated polymers may include polysulfones or polyimides. The sulfonated polymers can be formed into membranes that may be used in proton exchange membrane fuel cells or as ion exchange membranes. The membranes formed from the sulfonated polymers exhibit improved properties over that of Nafion®. A heteropoly acid may be added to the sulfonated polymer to form a nanocomposite membrane in which the heteropoly acid is highly dispersed. The addition of a heteropoly acid to the sulfonated polymer increases the thermal stability of the membrane, enhances the conductivity above 100° C., and reduces the water uptake of the membrane.Type: GrantFiled: July 29, 2010Date of Patent: February 26, 2013Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: James E. McGrath, Michael Hickner, Feng Wang, Yu-Seung Kim
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Publication number: 20120329958Abstract: The present invention includes a polymer formed by the thermal rearrangement of an ortho-functional polyimide synthesized via chemical imidization with permeation properties for gas separation membranes higher than those synthesized via thermal imidization and a method for forming that polymer having tailored transport properties and different chemical resistance. The present invention also includes a polymer formed by the thermal rearrangement of an ortho-functional polyimide in which a portion of the ortho-position functional group is lost during thermal rearrangement to yield a thermally rearranged polymer with higher permeability than would be seen without the ortho-position group. This ortho-position group can be the result of chemical imidization, or the result of a post-imidization modification reaction.Type: ApplicationFiled: June 1, 2012Publication date: December 27, 2012Applicants: Virginia Tech Intellectual Properties, Inc., Board of Regents, The University of Texas SystemInventors: Benny D. Freeman, David Sanders, Claudio P. Ribeiro, JR., Zachary Smith, James E. McGrath, Ruilan Guo
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Patent number: 8028842Abstract: The present invention provides a membrane, kit, and method of making a hydrophilic-hydrophobic random copolymer membrane. The hydrophilic-hydrophobic random copolymer membrane includes a hydrophilic-hydrophobic random copolymer. The hydrophilic-hydrophobic random copolymer includes one or more hydrophilic monomers having a sulfonated polyarylsulfone monomer and a second monomer and one or more hydrophobic monomers having a non-sulfonated third monomer and a fourth monomer. The sulfonated polyarylsulfone monomer introduces a sulfonate into the hydrophilic-hydrophobic random copolymer prior to polymerization.Type: GrantFiled: January 18, 2007Date of Patent: October 4, 2011Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: James E. McGrath, Ho Bum Park, Benny D. Freeman
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Publication number: 20110223521Abstract: Sulfonated polymers are made by the direct polymerization of a sulfonated monomer to form the sulfonated polymers. The types of sulfonated polymers may include polysulfones or polyimides. The sulfonated polymers can be formed into membranes that may be used in proton exchange membrane fuel cells or as ion exchange membranes. The membranes formed from the sulfonated polymers exhibit improved properties over that of Nafion®. A heteropoly acid may be added to the sulfonated polymer to form a nanocomposite membrane in which the heteropoly acid is highly dispersed. The addition of a heteropoly acid to the sulfonated polymer increases the thermal stability of the membrane, enhances the conductivity above 100° C., and reduces the water uptake of the membrane.Type: ApplicationFiled: July 29, 2010Publication date: September 15, 2011Inventors: James E. McGrath, Michael Hickner, Feng Wang, Yu-Seung Kim
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Publication number: 20110213456Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.Type: ApplicationFiled: May 5, 2011Publication date: September 1, 2011Applicant: REVA Medical, Inc.Inventors: Donald K. Brandom, James E. McGrath, Joan Zeltinger, Eric V. Schmid, Robert K. Schultz
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Publication number: 20100228343Abstract: A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.Type: ApplicationFiled: October 11, 2009Publication date: September 9, 2010Applicant: Rutgers, the State UniversityInventors: Don K. BRANDOM, Durgadas Bolikal, Lioubov Kabalnova, James E. McGrath, Joachim Kohn
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Patent number: 7790314Abstract: A membrane electrode assembly for a fuel cell is described. The materials for the membrane electrode assembly are formed from sulfonated polymers. A polymer dispersion ink containing the sulfonated polymer and a mixture of solvents is used to form the electrodes on the exchange membrane. The dispersion ink allows for the electrodes to be formed directly on the exchange membrane without significantly dissolving the exchange membrane.Type: GrantFiled: June 5, 2009Date of Patent: September 7, 2010Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: James E. McGrath, Michael Hickner
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Patent number: 7790837Abstract: Sulfonated polymers are made by the direct polymerization of a sulfonated monomer to form the sulfonated polymers. The types of sulfonated polymers may include polysulfones or polyimides. The sulfonated polymers can be formed into membranes that may be used in proton exchange membrane fuel cells or as ion exchange membranes. The membranes formed from the sulfonated polymers exhibit improved properties over that of Nafion®. A heteropoly acid may be added to the sulfonated polymer to form a nanocomposite membrane in which the heteropoly acid is highly dispersed. The addition of a heteropoly acid to the sulfonated polymer increases the thermal stability of the membrane, enhances the conductivity above 100° C., and reduces the water uptake of the membrane.Type: GrantFiled: February 21, 2008Date of Patent: September 7, 2010Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: James E. McGrath, Michael Hickner, Feng Wang, Yu-Seung Kim
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Publication number: 20090239125Abstract: A membrane electrode assembly for a fuel cell is described. The materials for the membrane electrode assembly are formed from sulfonated polymers. A polymer dispersion ink containing the sulfonated polymer and a mixture of solvents is used to form the electrodes on the exchange membrane. The dispersion ink allows for the electrodes to be formed directly on the exchange membrane without significantly dissolving the exchange membrane.Type: ApplicationFiled: June 5, 2009Publication date: September 24, 2009Inventors: James E. McGrath, Michael Hickner
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Patent number: 7544764Abstract: A membrane electrode assembly for a fuel cell is described. The materials for the membrane electrode assembly are formed from sulfonated polymers. A polymer dispersion ink containing the sulfonated polymer and a mixture of solvents is used to form the electrodes on the exchange membrane. The dispersion ink allows for the electrodes to be formed directly on the exchange membrane without significantly dissolving the exchange membrane.Type: GrantFiled: April 1, 2003Date of Patent: June 9, 2009Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: James E. McGrath, Michael Hickner
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Patent number: 7473714Abstract: A family of polymers having pendent sulfonate moieties connected to polymeric main chain phenyl groups are described. These polymers are prepared by the steps of polymerization (using a monomer with a phenyl with an alkoxy substitution), deportation by converting the alkoxy to a hydroxyl, and functionalization of the polymer with a pendant sulfonate group. As an example, sulfonated poly(arylene ether sulfone) copolymers with pendent sulfonic acid groups are synthesized by the direct copolymerization of methoxy-containing poly(arylene ether sulfone)s, then converting the methoxy groups to the reactive hydroxyl form, and finally functionalizing the hydroxyl form with proton-conducting sites through nucleophilic substitution. The family of polymers may have application in proton exchange membranes and in other applications.Type: GrantFiled: May 2, 2005Date of Patent: January 6, 2009Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Brian R. Einsla, James E. McGrath
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Publication number: 20080275146Abstract: Sulfonated polymers are made by the direct polymerization of a sulfonated monomer to form the sulfonated polymers. The types of sulfonated polymers may include polysulfones or polyimides. The sulfonated polymers can be formed into membranes that may be used in proton exchange membrane fuel cells or as ion exchange membranes. The membranes formed from the sulfonated polymers exhibit improved properties over that of Nafion®. A heteropoly acid may be added to the sulfonated polymer to form a nanocomposite membrane in which the heteropoly acid is highly dispersed. The addition of a heteropoly acid to the sulfonated polymer increases the thermal stability of the membrane, enhances the conductivity above 100° C., and reduces the water uptake of the membrane.Type: ApplicationFiled: February 21, 2008Publication date: November 6, 2008Inventors: James E. McGrath, Michael Hickner, Feng Wang, Yu-Seung Kim
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Patent number: 7375178Abstract: High refractive index, melt processable polyphosphonates and methods for preparing the same are provided. These polymers are particularly useful for optical and ophthalmic parts, such as lenses. A method of preparing optical and ophthalmic lenses by injection molding the polymers of the present invention into the form of the optical or ophthalmic lenses is also provided.Type: GrantFiled: June 27, 2006Date of Patent: May 20, 2008Assignee: Essilor InternationalInventors: Hosadurga K. Shobha, Venkat Sekharipuram, James E. McGrath, Atul Bhatnagar