Abstract: This invention relates to a class of pyrrolidine compounds of formula (I), and pharmaceutically acceptable derivatives thereof, to their use in medicine, to compositions containing them, and to processes for their preparation. It also relates to intermediates used in the preparation of such compounds and derivatives. In particular the compounds of formula (I) are useful for the treatment of EP2-mediated conditions, such as endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), chronic pelvic pain syndrome.

Abstract: This invention relates to a class of pyrrolidine compounds of formula (I), and pharmaceutically acceptable derivatives thereof, to their use in medicine, to compositions containing them, and to processes for their preparation. It also relates to intermediates used in the preparation of such compounds and derivatives. In particular the compounds of formula (I) are useful for the treatment of EP2-mediated conditions, such as endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), chronic pelvic pain syndrome.

Abstract: A vehicle axle is provided that includes a spindle supporting a wheel hub having a toothed wheel. A tapered axle portion is adjacent to said spindle, and an ABS sensor bracket is secured to the tapered portion. The bracket has a body defining a hole receiving an ABS sensor adjacent the toothed wheel. The bracket includes a pedestal extending from the body and terminating in a base extending transversely from the pedestal. Reinforcing ribs may be used between the base and pedestal to strengthen the area. The base secured to the axle portion by a weld arranged in a notch in the base and another weld arranged at the rear of the base. The bracket is preferably secured to the axle by an automated process in which the axle is already precisely oriented for a procedure to the axle, such as the attachment of the brake spider.

Abstract: A vehicle suspension assembly includes a device for securing an axle to a selected suspension component. A seat member that is received between the axle and the suspension component includes an axle adaptor as part of the seat member. A first portion of the seat member is received between the axle and the suspension component. A second portion of the seat member extends away from the first portion and includes at least one support surface for supporting a brake component relative to the axle. In one example embodiment, the seat member includes an integrated brake carrier.

Abstract: A vehicle axle is provided that includes a spindle supporting a wheel hub having a toothed wheel. A tapered axle portion is adjacent to said spindle, and an ABS sensor bracket is secured to the tapered portion. The bracket has a body defining a hole receiving an ABS sensor adjacent the toothed wheel. The bracket includes a pedestal extending from the body and terminating in a base extending transversely from the pedestal. Reinforcing ribs may be used between the base and pedestal to strengthen the area. The base secured to the axle portion by a weld arranged in a notch in the base and another weld arranged at the rear of the base. The bracket is preferably secured to the axle by an automated process in which the axle is already precisely oriented for a procedure to the axle, such as the attachment of the brake spider.

Abstract: A vehicle suspension assembly includes a device for securing an axle to a selected suspension component. A seat member that is received between the axle and the suspension component includes an axle adaptor as part of the seat member. A first portion of the seat member is received between the axle and the suspension component. A second portion of the seat member extends away from the first portion and includes at least one support surface for supporting a brake component relative to the axle. In one example embodiment, the seat member includes an integrated brake carrier.

Abstract: An axle and brake mounting assembly includes a brake carrier secured directly to the axle. In one example, the brake carrier includes a portion that completely surrounds a corresponding portion of the axle. The brake carrier in one example is welded directly to the axle.

Abstract: A versatile portable support for cameras, spotting scopes, and other devices is shown secured to a collateral support object (tree). A rope or the like is attached to a central hub member (FIG. 4), and encircled about a collateral support object one or more times, and then tightly placed in rope gripping clamps (FIG. 9). An optical device attachment assembly (FIG. 14), is removably coupled to an arm member (FIG. 10), which rotably and extendably supports cameras, spotting scopes, and other devices. My support is also shown configured so as to stand, tripod-like, on a generally horizontal surface. A central hub member (FIG. 4), houses an arm member hub (FIG. 11) and an elongated leg hub member (FIG. 7). Rotation of cam lock knob (FIG. 5) , disengages central hub member (FIG. 4), enabling rotational adjustment of tree leg assembly (FIG. 8), plural elongated leg assembly (FIG. 6), and arm member (FIG. 10), about central rotational axis 69 of central hub member (FIG. 4).

Abstract: The efficiency of a microwave oven of a conventional two-source configuration and energy level is increased by providing the oven with a container for housing a refractory material to be treated. The container is formed of top and bottom walls transparent to microwaves while the sidewalls, in a circular configuration, are formed of a nonmetallic material opaque to microwave radiation reflecting the radiation penetrating the top and bottom walls radially inwardly into the center of the container wherein a casket of heat-insulating material is provided for housing the material to be heat treated. The reflection of the microwave radiation from the sidewalls increases the concentration of the microwaves upon the material being heat treated while the casket retains the heat to permit the heating of the material to a substantially higher temperature than achieveable in the oven without the container.