Abstract: The present disclosure provides wearable devices for use in generating electrocardiograms. The wearable devices may be used by a user (e.g., in combination with an app) to determine a likelihood that the user is undergoing a health emergency. A wearable device may include at least 9 precordial leads. A wearable device may include one or more leads in a V7, V8, or V9 position, or a combination thereof. A wearable device may include two rows of leads (e.g., two leads in each of a number of positions).

Abstract: The present disclosure provides methods and systems for alerting users to a likelihood that they are experiencing a health emergency. A method may include comparing current health data for a user to patient history data for the user to determine one or more probabilistic measurements corresponding to a likelihood that a user is undergoing a health emergency, such as a cardiac emergency and/or neurological emergency. If the probabilistic measurement(s) exceed a threshold, the method may include outputting a notification, such as an auditory and/or graphical notification, automatically alerting (e.g., calling) emergency medical services, or both. The method may be initiated by a user at the onset of one or more symptoms by opening an application or webpage. The method may use this initial input of symptom(s) to determine whether to proceed with requesting, and receiving, current health data to assist in the determination of the one or more probabilistic measurements.

Abstract: Described herein are systems with interleaved light sources and methods of their use. In some embodiments, a system includes a plurality of light sources, each of which has a bright phase and a dark phase, the system being arranged and constructed so that, for a first light source and a second light source of the plurality, the bright phase of the first light source occurs during the dark phase of a second light source. The example method may further include providing light from the second light source during a dark phase of the first light source. A first and/or second light source may be a swept source or a broadband source. A first and/or second light source may be a laser.

Abstract: Methods, apparatus, and systems for intravascular analysis combine at least three analytical modalities. In one implementation, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy are combined to enable detection of multiple, different abnormalities in the arterial morphology during a single intravascular procedure.

Abstract: Methods, apparatus, and systems for intravascular analysis combine at least three analytical modalities. In one implementation, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy are combined to enable detection of multiple, different abnormalities in the arterial morphology during a single intravascular procedure.

Abstract: Methods, apparatus, and systems for intravascular analysis combine at least three analytical modalities. In one implementation, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy are combined to enable detection of multiple, different abnormalities in the arterial morphology during a single intravascular procedure.

Abstract: Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric imaging of arteries to non-destructively locate and determine lipid pool and fibrous cap size and composition. Additionally, mediators and cellular components may be also determined that are typically associated with vulnerable plaques which have an increased risk of rupture.

Abstract: Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric imaging of arteries to non-destructively locate and determine lipid pool and fibrous cap size and composition. Additionally, mediators and cellular components may be also determined that are typically associated with vulnerable plaques which have an increased risk of rupture.