Patents by Inventor James E. Posey

James E. Posey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Eis inhibitors
    Patent number: 10208000
    Abstract: Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 19, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey
  • EIS INHIBITORS
    Publication number: 20170174639
    Abstract: Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
    Type: Application
    Filed: December 16, 2016
    Publication date: June 22, 2017
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey