Abstract: The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.

Abstract: This invention provides certain substituted benzenesulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier.

Abstract: The floral arrangement holder has a base which supports a foam block in contact with the upper surface of the base. Drain holes are provided so that any excess water can run into the hollow base portion. Recessed reservoir channels are provided in the upper surface of the base, to allow any excess water in one portion of the block to flow to a drier portion, and to allow water to wick upwardly into the block from the channels. A filling area extends outwardly from the base for convenient access, and has an upper surface which preferably is angled slightly downwardly towards the channels for better distribution of the water. The filling area also doubles as a convenient hand grip, by virtue of being provided with finger recesses. A clip arrangement holds the foam block in place. An elongated version of the holder holds two such blocks, and includes an extended end portion to provide greater-water storage capacity, particularly useful if the holder is suspended via an apertured tab at the opposite end.

Abstract: A floral display holder has a hollow body with a frontal recess for receiving a water-absorbing foam, and a manual pump to draw water from a lower portion defining a liquid reservoir. The floral display holder has U-shaped clips to secure the foam generally against a floor surface of the recess. The water drawn with the pump is directed onto the foam, thereby replenishing the foam with additional water.

Abstract: A floral display holder to be used on a funeral casket has a hollow body with an inclining recess for receiving water-absorbing foams, and a manual pump to draw water from a lower portion defining a liquid reservoir. The floral display holder has U-shaped clips to secure the foams generally against an inclined floor surface of the recess. The water drawn with the pump is directed onto the foam, thereby replenishing the foam with additional water.

Abstract: This invention provides certain substituted 2,3-dihydrobenzofurylsulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier.

Abstract: The present invention is directed to azetidinone compounds of the following formula: ##STR1## which are useful as intermediates to carbacephalosporins: ##STR2## These carbacephalosporins are useful as antibacterials.

Abstract: This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.

Abstract: This invention provides certain benzenesulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier, and processes for preparing the benzenesulfonamide derivatives.

Abstract: This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.

Abstract: A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.

Abstract: This invention provides certain N-phenyl-N'-substituted phenylsulfonylureas compounds, formulations, and a method for treating susceptible neoplasms in mammals using the sulfonylurea compounds.

Abstract: This invention provides the use of certain indenesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel indenesulfonamide derivatives and their pharmaceutical formulations.