Abstract: The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, prevention, amelioration and treatment of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.

Abstract: A process for selectively immobilizing viral glycoproteins on lectin-coated surfaces for use in solid phase immunoassays is disclosed. This method does not require that the virus or antigen be purified prior to immobilization. This method provides an inexpensive and effective immunoassay method to screen fluids for the presence of viral antibodies.

Abstract: The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, pervention of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.

Abstract: The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.

Abstract: A thermal detection system (10) includes a focal plane array (12), a thermal isolation structure (14), and an integrated circuit substrate (16). Focal plane array (12) includes thermal sensors (28), each having an associated thermal sensitive element (30). Thermal sensitive element (30) is coupled with one side to infrared absorber and common electrode assembly (36) and on the opposite side to an associated contact pad (20) disposed on the integrated circuit substrate (16). Reticulation kerfs (52a, 52b) separate adjacent thermal sensitive elements (30a, 30b, 30c) by a distance at least half the average width (44, 46) of a single thermal sensitive element (30a, 30b, 30c). A continuous, non-reticulated optical coating (38) may be disposed over thermal sensitive elements (30a, 30b, 30c) to maximize absorption of thermal radiation incident to focal plane array (12).

Abstract: A thermal imaging system (10) contains a focal plane array (14) including a plurality of thermal sensors (50) mounted on a substrate (52). The focal plane array (14) generates both a reference signal which represents the temperature of the substrate (52) and a biased signal corresponding to the total radiance emitted by a scene (11). Electronics (16) process the reference signal and the biased signal to obtain an unbiased signal representing radiance differences emitted by objects in the scene (11). A thermoelectric cooler/heater (38) may be provided to optimally adjust the temperature of the substrate (52) to improve overall image quality. Each thermal sensor (50) contains an electrode (66 and 68) that electrically couples the thermal sensor (50) to the substrate (52) and also allows the thermal sensor (50) to deflect, contact, and thermally shunt with the substrate (52).

Abstract: A thermal detection system (10) includes a focal plane array (12), a thermal isolation structure (14), and an integrated circuit substrate (16). Focal plane array (12) includes thermal sensors (28), each having an associated thermal sensitive element (30). Thermal sensitive element (30) is coupled with one side to infrared absorber and common electrode assembly (36) and on the opposite side to an associated contact pad (20) disposed on the integrated circuit substrate (16). Reticulation kerfs (52a, 52b) separate adjacent thermal sensitive elements (30a, 30b, 30c) by a distance at least half the average width (44, 46) of a single thermal sensitive element (30a, 30b, 30c). A continuous, non-reticulated optical coating (38) may be disposed over thermal sensitive elements (30a, 30b, 30c) to maximize absorption of thermal radiation incident to focal plane array (12).

Abstract: A compact, portable satellite dish antenna system comprises a dish-shaped member having an inner surface that includes a central circular flat area and a plurality of annular parabolically-shaped segments concentric with the central circular flat area for providing a plurality of focal points over the inner surface of the dish-shaped member to thereby improve the signal gathering characteristics of the dish antenna system.

Abstract: An incubator and an incubator method using two independently driven incubator rings each holding and transferring a liquid-containing cuvette between processing stations. At least one reagent addition station is disposed permanently adjacent each of the two rings. One advantageous result is enhanced throughput compared to having only one such ring for all reagent addition stations.

Abstract: A device for the replacement of wheels on trains comprising a generally flat framework having a longitudinal opening extending therethrough, a first wheel receiving area rigidly affixed to the framework for abutting a surface of a wheel, and a second wheel receiving area rigidly affixed to the framework and disposed distal from the first wheel receiving area on the framework. The longitudinal opening receives the periphery of a train wheel. The framework includes a first longitudinal member, a second longitudinal member, and a transverse member rigidly connected across the longitudinal members for maintaining the longitudinal members in parallel alignment. The longitudinal opening has a width sufficient, in combination with the thickness of the longitudinal members, to cause the periphery of the train wheels to raise above the top surface of a railroad track.

Abstract: A vacuum sample introduction device includes a roller bearing assembly which rigidly supports a probe rod for accurate reciprocation relative to the device.

Abstract: A plastic material extruder having a barrel and an outer sheath with heating and cooling means in the outer sheath is disclosed, together with means for maintaining the temperature of the inner barrel, including two temperature sensing devices, one on the barrel and one on the other sheath, the sensing devices connected to control circuitry which actuates the heating and cooling means to maintain a temperature gradient between the two sensors by sensing the temperature change from the barrel and adjusting the set point of the sensing device on the sheath.

Abstract: A sample loading device for loading samples into and unloading samples from an ultra high vacuum analysis chamber without the necessity to raise and lower pressure each time a sample loading or unloading is effected, is described. The sample is initially positioned in a chamber of comparatively small volume which can be rapidly and simply evacuated to a vacuum approximating that of the analysis chamber. A gate valve between the small volume chamber and the analysis chamber then is opened and the sample introduced to the analysis chamber by a simple rack-and-pinion mechanism. Fine positioning of the sample and release of the carrier from the insertion fork is achieved by external X- and Y-axis adjustments.

Abstract: An extruder for simultaneously extruding two plastics materials without intermixing thereof prior to exiting the extruder. The extruder barrel has two feed hoppers at one end and an outlet at the opposite end and contains a rotatable screw with two spaced screw threads of the same handedness which form two helical channels, each fed from one of the hoppers. One channel extends from a hopper to the outlet and the other channel is blocked in advance of the outlet so that substantially all the material therein is forced to enter a passage in the screw which extends to the outlet. Also, a process for extruding the two plastics materials and for coating a wire with two layers with a die having a single material receiving channel.

Abstract: A visible light and near infrared imaging device is disclosed. The imaging device comprises X-Y addressing means, an array of opto-electronic semiconductor elements or cells, a multiplexer, a precharge switch, and an amplifier. The X-Y addressing means selectively addresses each cell of the array of opto-electronic semiconductor cells and corresponding multiplexer switch for connecting a reference voltage to each cell to charge each element to the reference voltage, then to isolate each element and vary its voltage in proportion to the intensity of the impinging light, and finally to read out selectively the voltage of each element to the amplifier for amplifying the electrical signals representative of the light intensity to a working level for processing into video signals.