Patents by Inventor James E. Seely

James E. Seely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
    Patent number: 5849694
    Abstract: The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a method for producing such a small-loop modified somatotropin. Also provided by the present invention are DNA sequences coding for such small-loop modified somatotropins, plasmids containing such sequences, and organisms containing such plasmids. Furthermore, pharmaceutical compositions including small-loop modified somatotropins and methods for using such pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: December 15, 1998
    Inventors: Richard M. Synenki, Peter M. Rubinelli, Henry E. Auer, James E. Seely
  • Growth hormone-releasing factor analogs
    Patent number: 5137872
    Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [Pro.sup.0, X.sup.15, Y.sup.27 ]-hGRF(1-A)-B, wherein X is selected from the group consisting of Ala and Gly, Y is selected from the group consisting of Ile, Leu, Val, Nle and Met, A has a value from 29-44, and B is NH.sub.2, OH or COOH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: August 11, 1992
    Assignee: Pitman-Moore, Inc.
    Inventors: James E. Seely, Hsi Meng
  • Protein recovery
    Patent number: 4656255
    Abstract: An improved process is described for recovering proteins from insoluble inclusion bodies produced in transformant microorganisms. Sidestream precipitates isolated from chromatography effluent are resolubilized in a denaturing agent and the resolubilized proteins are renatured either by direct dialysis into denaturant-free buffer or by dialysis into a weaker denaturing agent followed by dialysis into denaturant-free buffer.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: April 7, 1987
    Assignee: International Minerals & Chemical Corp.
    Inventor: James E. Seely