Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Abstract: Examples described herein relate to a graphics processing system that includes one or more integrated graphics systems and one or more discrete graphics systems. In some examples, an operating system (OS) or other software supports switching between image display data being provided from either an integrated graphics system or a discrete graphics system by configuring a multiplexer at runtime to output image data to a display. In some examples, a multiplexer is not used and interface supported messages are used to transfer image data from an integrated graphics system to a discrete graphics system and the discrete graphics system generates and outputs image data to a display. In some examples, interface supported messages are used to transfer image data from a discrete graphics system to an integrated graphics system and the integrated graphics system uses an overlay process to generate a composite image for output to a display.

Abstract: A damped compressor used in mobile appliances. The appliances may comprise a compressor which is disposed within a housing and is in fluid communication with a refrigerant system. Within the housing there is an improved damping or stabilizer system which limits movement of electric or mechanical portions, or both, of the compressor within the housing. At startup and shutdown, when oscillations of the components within the housing are generally maximized, the components are limited from contacting the housing internal structure so as to inhibit damage to the compressor and reduce the noise associated with such contact. The components are also damped from movement associated with the mobile application of the compressor.

Abstract: An improvement to a standardized design of a body for small-bore connectors for liquids and/or gases in a healthcare application, wherein the body has a spout with a standardized upper portion. The upper portion can have a standardized external thread or can have a different size and shape for the external thread. The body can have a standardized internal flange or another differently sized and shaped internal flange. The body can have an internal void though which the liquids and/or gases flow. At least a portion of the standardized internal flange or another internal flange can be eliminated or removed to reduce a flow restriction caused by the standardized internal flange and thus increase a flow area of the internal void.

Abstract: An example system and corresponding method can include a combustion chamber of jet engine, a radio-frequency power source, and a resonator. The combustion chamber can include a liner defining a combustion zone, and include a fuel inlet configured to introduce fuel into the combustion zone. The resonator can have a resonant wavelength and include: a first conductor, a second conductor, a dielectric, and an electrode coupled to the first conductor. The resonator can be configured such that, when the resonator is excited by the radio-frequency power source with a signal having a wavelength proximate to an odd-integer multiple of one-quarter (¼) of the resonant wavelength, the resonator provides a plasma corona in the combustion zone. The controller can be configured to cause the radio-frequency power source to excite the resonator with the signal so as to provide the plasma corona.

Abstract: An apparatus for igniting a combustible mixture. In one example, the apparatus can include a coaxial cavity resonator assembly in a combustion environment. The apparatus can also include an operational feedback system and a controller. The operational feedback system can measure at least one of a voltage value and a current value of the coaxial cavity resonator assembly in the combustion environment. The controller can be configured to determine a condition of the coaxial cavity resonator assembly and modulate operation of the coaxial cavity resonator assembly based at least in part on the determined condition.

Abstract: A wind turbine is disclosed. The wind turbine includes a shaft rotatable about an axis, a plurality of hubs fixedly attached to the shaft, and a plurality of vanes. The vanes are releasably engaged with each of the plurality of hubs. The vanes disengage from the hubs once the shaft rotates about the axis at a cut-out speed of the wind turbine. In another embodiment, the vanes are releasably engaged with the shaft.

Abstract: An apparatus for igniting a combustible mixture. In one example, the apparatus can include a coaxial cavity resonator assembly in a combustion environment. The apparatus can also include an operational feedback system and a controller. The operational feedback system can measure at least one of a voltage value and a current value of the coaxial cavity resonator assembly in the combustion environment. The controller can be configured to determine a condition of the coaxial cavity resonator assembly and modulate operation of the coaxial cavity resonator assembly based at least in part on the determined condition.

Abstract: An apparatus comprises a coaxial cavity resonator; a radio frequency power source coupled to the coaxial cavity resonator; a direct current power source coupled to the coaxial cavity resonator; a combustion process feedback module configured to sense a condition in a combustion environment by measuring a characteristic of the coaxial cavity resonator; and a controller configured to modulate operation of the coaxial cavity resonator based at least in part on combustion process feedback information from the combustion process feedback module.

Abstract: A wind turbine is disclosed. The wind turbine includes a shaft rotatable about an axis, a plurality of hubs fixedly attached to the shaft, and a plurality of vanes. The vanes are releasably engaged with each of the plurality of hubs. The vanes disengage from the hubs once the shaft rotates about the axis at a cut-out speed of the wind turbine. In another embodiment, the vanes are releasably engaged with the shaft.

Abstract: A quarter wave coaxial cavity resonator for producing corona discharge plasma from is presented. The quarter wave coaxial cavity resonator has a folded cavity made of opposing concentric cavity members that are nested together to form a continuous cavity ending in a aperture. A center conductor with a tip is positioned in the cavity. The folded cavity advantageously permits the coaxial cavity resonator to resonate at a lower operating frequency than an unfolded quarter wave coaxial cavity resonator of the same length. Embodiments of the quarter wave coaxial cavity resonator use narrower apertures to reduce radiative losses, and include center conductors that are reactive load elements, such as helical coils. When a radio frequency (RF) oscillation is produced in the quarter wave coaxial cavity resonator, corona discharge plasma is formed at the tip of the center conductor. The corona discharge plasma can be used to ignite combustible materials in combustion chambers of combustion engines.

Abstract: A wind turbine is disclosed. The wind turbine includes a shaft rotatable about an axis, a plurality of hubs fixedly attached to the shaft, and a plurality of vanes. The vanes are releasably engaged with each of the plurality of hubs. The vanes disengage from the hubs once the shaft rotates about the axis at a cut-out speed of the wind turbine. In another embodiment, the vanes are releasably engaged with the shaft.

Abstract: An exercise machine is provided for agonist-antagonist muscle training. A first variable resistance mechanism has a first line extending therefrom, a second variable resistance mechanism has a second line extending therefrom, and a user-engaged link is coupled to the first line and second line with the first line, second line, and link being aligned along a common axis. When the user applies a first tensile force to the first line via the link, the first line extends from the first variable resistance mechanism against its resistance force while the second line retracts towards the second variable resistance mechanism under its restoring force. Then, when the user applies a second tensile force to the second line via the link, the second line extends from the second variable resistance mechanism against its resistance force while the first line retracts towards the first variable resistance mechanism under its restoring force.

Abstract: The invention provides a system for detecting leaks in glovebox gloves, the system having a first seal within a glovebox aperture; a second seal contacting exterior surfaces of a glovebox, wherein the exterior surfaces define a periphery of the aperture; a first fluid supply for circumferentially expanding the first seal against center facing surfaces of the aperture to a first pressure; a second fluid supply for inflating the glove to a second pressure; and a pressure gauge for detecting a pressure decrease of the second pressure. Also provided is an in situ method for detecting leaks in glove box gloves, the method having the steps of applying a radially directed force to inside surfaces of cuffs of the gloves to hermetically seal the gloves from the exterior of the glovebox, thereby establishing a seal; inflating the gloves to a pressure; and monitoring the pressure for any decrease in pressure.

Abstract: An apparatus comprises a coaxial cavity resonator; a radio frequency power source coupled to the coaxial cavity resonator; a direct current power source coupled to the coaxial cavity resonator; a combustion process feedback module configured to sense a condition in a combustion environment by measuring a characteristic of the coaxial cavity resonator; and a controller configured to modulate operation of the coaxial cavity resonator based at least in part on combustion process feedback information from the combustion process feedback module.

Abstract: An example system and corresponding method can include a combustion chamber of jet engine, a radio-frequency power source, and a resonator. The combustion chamber can include a liner defining a combustion zone, and include a fuel inlet configured to introduce fuel into the combustion zone. The resonator can have a resonant wavelength and include: a first conductor, a second conductor, a dielectric, and an electrode coupled to the first conductor. The resonator can be configured such that, when the resonator is excited by the radio-frequency power source with a signal having a wavelength proximate to an odd-integer multiple of one-quarter (¼) of the resonant wavelength, the resonator provides a plasma corona in the combustion zone. The controller can be configured to cause the radio-frequency power source to excite the resonator with the signal so as to provide the plasma corona.

Abstract: The present disclosure generally pertains to methods for the harvesting of biomass, in particular algae, from dilute aqueous suspension. In one embodiment, the method comprises the steps of: adjusting the pH of the dilute aqueous suspension to cause disruption of the algal cell walls and exposure of the hydrophobic tails of the algal lipid bilayer; adding at least one organic solvent to the dilute aqueous suspension; and mixing the dilute aqueous suspension. The method may also include the steps of: waiting for formation of an organic layer from the dilute aqueous suspension; and recovering the organic layer. The organic layer rises to the top of the dilute aqueous suspension, allowing for mechanical separation or decanting of the organic layer.

Abstract: A method, system and computer program product are provided for implementing cable failover in multiple cable Peripheral Component Interconnect Express (PCIE) IO interconnections to an external IO enclosure. System firmware is provided for implementing health check functions for the PCIE IO interconnections to identify a faulted low byte cable. A cable failover mechanism recovers a PCI link to the external IO enclosure. A multiplexer logic is provided between the PCIE host bridge (PHB) and the cable connected to the IO enclosure to perform a full lane reversal of the PCIE lanes.