Patents by Inventor James E. Stefano

James E. Stefano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGOSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20110300120
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: December 11, 2009
    Publication date: December 8, 2011
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • PEPTIDE ANALOGS OF ALPHA-MELANOCYTE STIMULATING HORMONE
    Publication number: 20090297444
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Application
    Filed: March 20, 2009
    Publication date: December 3, 2009
    Inventors: Michael A. Perricone, John Lyle Dzuris, Timothy E. Weeden, James E. Stefano, Clark Q. Pan, Andrea E. Edling
  • Method for detecting and identifying mutations
    Patent number: 6297010
    Abstract: This invention provides various methods for identifying one or more genetic alterations in a sample polynucleotide strand.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: October 2, 2001
    Assignee: Genzyme Corporation
    Inventor: James E. Stefano
  • Selective amplification system using Q-.beta. replicase
    Patent number: 5556751
    Abstract: Mutant forms of midivariant RNA are disclosed which are replicated efficiently by the enzyme Q.beta. replicase in the presence of an agent(s) which is useful for the real time, quantitative detection of the accumulating RNA products. This agent(s) also suppresses the replication of non-mutant wild type midivariant RNA. The mutant MDV RNAs, when modified by the addition of specific probe sequences, retain their replication properties in the presence of the detection agent. This method allows the replication to be monitored using a real time mode thereby providing a reliable method for monitoring the kinetics of the reaction, and determining the initial level of amplified RNA.
    Type: Grant
    Filed: April 5, 1994
    Date of Patent: September 17, 1996
    Assignee: Amoco Corporation
    Inventor: James E. Stefano
  • Nucleic acid structures with catalytic and autocatalytic replicating features and methods of use
    Patent number: 5472840
    Abstract: Methods and compositions are described for making ribozymes which can release or activate molecules including autocatalytically replicatable RNA such as MDV-1.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: December 5, 1995
    Assignee: Amoco Corporation
    Inventor: James E. Stefano