Abstract: A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The heater element can have more than one heating zone, with at least one of the heating zones being selectively energizable. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements.

Abstract: A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.

Abstract: In a preferred embodiment, there is an electronic comparator that monitors and exhibits on one or more video displays current information measured and monitored as to physical attributes relating to a revolvably rotating linearly-extending stirring shaft of which a distal end carries stirring blades positioned within media supported within a vessel stably mounted relative to a stably mounted drive mechanism and the stirring shaft, and a visual display video that during stirring displays visually the measured and monitored current degree of wobble of the stirring shaft, magnitude of vibrations of the stirring shaft, current degree of verticality of the stirring shaft, current temperature of media being stirred by the stirring shaft, current rate of revolutions per unit of time of the stirring shaft, a printing mechanism that prints current measured and monitored physical attributes onto a substrate, a computer interface structure and mechanism thereof adapted to convey measured and monitored physical attribute

Abstract: For specialized use to secure reliable standardized complete distribution or solution of aggregate mixed into a liquid diluent, a vessel having an interior hemispherical concave bottom having extending upwardly centrally from the concave bottom an arcuate conical member having upright concavely-shaped circumscribing sides. The vessel is taken in conjunction with a stably mounted mixing structure having a downwardly-extending shaft and mixing blades thereof. The shaft on a lower portion thereof supports balanced mixing blades extending radially outwardly from the mixing shaft. The mixing blades are positioned to be substantially spaced below a predetermined liquid level of liquid diluent containing a dissolvable or suspendable aggregate and to be substantially spaced above an upper end of the centrally upwardly arcuate conical member.

Abstract: In a transdermal cell, a matter volume-adjustment male device includes the lower opening end of the through-space structure having inner wall female threads mateable with first male threads of a screwable matter volume-adjustment male member alternately adjustable upwardly and downwardly between opposite upper and lower female threads-termination points. The screwable matter volume-adjustment member has opposite first upper and lower male threads-termination points, and the inner wall female threads are further concurrently mateable with a bottom closure member having second male threads having opposite second upper and lower male threads-termination points.

Abstract: In a preferred embodiment, a vessel-mouth annulus that precisely fits the inside-diameter of the upper mouth-opening to a water-containable tablet-dissolution stirring vessel, the vessel-mouth annulus being rigidly mounted on an anchoring structure rigidly attached to a paddle-shaft stirring device with one or more of the anchoring arm and/or the paddle-shaft stirring device being mounted in a predetermined fixed position on a base support structure such that a center of the dissolution vessel is centered in exact alignment with a predetermined fixed-position of a downwardly-extending lineally-extending stirrer-paddle shaft on which at-least one stirrer paddle is mounted on a lower end thereof for stirring liquid contained in the dissolution vessel during its operational use, and dissolution vessel support structure positioned to support the dissolution vessel in a state of alignment when the dissolution vessel is pressed upwardly against the aligning guide and holding means in a state of being aligned agains

Abstract: In a preferred embodiment of the invention, a transdermal patch holder is provided for making possible an ascertaining of drug release rate of a transdermal patch mountable thereon. The holder includes upper and lower spaced-apart aligned annular adapter disc structures forming aligned through-spaces. An upper surface of the lower disc structure has a centrally positioned stepped indentation forming a recess space seatable of the transdermal patch. The lower surface of the upper disc structure has a centrally positioned stepped downwardly-extending projection of slightly lesser cross-section than the cross-section of the recess space and is adapted to downwardly press upon an upper surface of a seated transdermal patch when the upper disc structure is intermittently in a latched state of being latched to the lower disc structure.

Abstract: A combination for observing and recording required periods of time for dissolution and/or disintegration of pharmaceutical solid dosage forms such as tablets, including one or more, preferably two electronic video camera lense mechanisms positioned at different locations of surveillance of a plurality of different separate tablet-containing vessels each separately supporting different tablet(s) with liquid media, as observed by the camera lenses through window(s) of camera-lens support structure anchored onto a vessel (waterbath) containing the liquid media, the tablet-containing vessels being moved alternately upwardly and downwardly and/or revolvably, with a time recorder recording intermittently or continuously exact times of surveillance testing of tablets, and a monitor for playing-back on a single or preferably divided-screen recorded observations and recorded times associated therewith.

Abstract: A tester of resistance of separate batches of tablets to breakage including a revolvable cylinder revolvable around a central height axis that extends axially of the cylinder, cylindrical space formed therein being divided into separate spaces by dividing walls extending radially across a diameter of the inner cylindrical space and the dividing walls for each space having a radially extending concave surface along one radius and a convex surface along another radius such that in each of the separate spaces there is formed a scoop facilitating collecting and tossing groups of tablets as the cylindrical cylinder revolves, and the revolvable cylinder including an access opening-structure for separate insertion and removal of tablets from the separate spaces before and after tumbling. The revolvable cylinder includes as a part of its combination, a motor mechanism for intermittently revolving the cylinder, and a male-female connection for mounting and dismounting in association with the motor mechanism.