Abstract: A drain treatment system includes a puck containment basket having an open top, sides, a bottom attached to the sides, and a rim attached to the sides at the open top. The sides and bottom of the puck containment basket have openings to permit liquid flow while restricting passage of solid debris. The system includes a cover that is movable or attachable to the puck containment basket at the open top or at the rim. The cover has openings to permit liquid flow while restricting the passage of solid debris. The cover can be positioned over the open top formed in the rim of the puck containment basket to form an enclosure. A drain treatment puck is insertable in and removable from the enclosure. Selected micro-organisms in the drain treatment puck are dispersed by the liquid and reduce clogging in the drain by a digestive action of the micro-organisms.