Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

Abstract: A backlit temperature control knob for water heater valves used with water heaters and more particularly to gas water heaters provides a way to read the temperature indication not previously known in the art. Some embodiments rely on a thermocouple or thermopile normally used to power a safety magnet with the pilot light system as a source of electrical energy to selectively illuminate a Light Emitting Diode (LED) which directs light through at least a portion of the knob to assist in reading the temperature indications.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A stand alone input device can be a touch pad that provides touch inputs to an associated computing device. The input device can include a wedge-shaped base defining an inner cavity, a touch plate having a touch surface disposed over the inner cavity and configured to accept a touch input, cantilevered beams coupled to the wedge-shaped base and the touch plate and configured to deliver a force from the touch input, a haptic generator coupled to the cantilevered beams and configured to generate a haptic output in response to the touch input, an antenna component integrated within a wall of the wedge-shaped base and an antenna resonance cavity located within the inner cavity, and a switch assembly including a sliding component having a pin through a wedge-shaped base wall and a switch beam having a protrusion that engages multiple recesses located at a detent region on the sliding component.

Abstract: A polarized electromagnetic actuator includes a movable armature, a stator, and at least one coil wrapped around the stator. At least one permanent magnet is disposed over the stator. When a current is applied to the at least one coil, the at least one coil is configured to reduce a magnetic flux of at least one permanent magnet in one direction and increase a magnetic flux of at least one permanent magnet in another direction. The movable armature moves in the direction of the increased magnetic flux.

Abstract: A method of isolating vibrations between vibrating bodies includes determining a pressure differential between a first fluid chamber and a second fluid chamber of a liquid inertia vibration eliminator (LIVE) unit, and selectively injecting fluid into or withdrawing fluid from the LIVE unit based on the pressure differential. A system for isolating vibrations between bodies includes a vibration isolator including fluid, a fluid regulator valve in fluid communication with the vibration isolator to selectively flow fluid through the vibration isolator, a pressurized fluid source in fluid communication with the fluid regulator to supply fluid to the fluid regulator, a controller in signal communication with the fluid regulator to control fluid flow between the fluid regulation valve and the vibration isolator, and at least one sensor in signal communication with the controller.

Abstract: A stand alone input device can be a touch pad that provides touch inputs to an associated computing device. The input device can include a wedge-shaped base defining an inner cavity, a touch plate having a touch surface disposed over the inner cavity and configured to accept a touch input, cantilevered beams coupled to the wedge-shaped base and the touch plate and configured to deliver a force from the touch input, a haptic generator coupled to the cantilevered beams and configured to generate a haptic output in response to the touch input, an antenna component integrated within a wall of the wedge-shaped base and an antenna resonance cavity located within the inner cavity, and a switch assembly including a sliding component having a pin through a wedge-shaped base wall and a switch beam having a protrusion that engages multiple recesses located at a detent region on the sliding component.

Abstract: A method of isolating vibrations between vibrating bodies includes determining a pressure differential between a first fluid chamber and a second fluid chamber of a liquid inertia vibration eliminator (LIVE) unit, and selectively injecting fluid into or withdrawing fluid from the LIVE unit based on the pressure differential. A system for isolating vibrations between bodies includes a vibration isolator including fluid, a fluid regulator valve in fluid communication with the vibration isolator to selectively flow fluid through the vibration isolator, a pressurized fluid source in fluid communication with the fluid regulator to supply fluid to the fluid regulator, a controller in signal communication with the fluid regulator to control fluid flow between the fluid regulation valve and the vibration isolator, and at least one sensor in signal communication with the controller.

Abstract: A polarized electromagnetic actuator includes a movable armature, a stator, and at least one coil wrapped around the stator. At least one permanent magnet is disposed over the stator. When a current is applied to the at least one coil, the at least one coil is configured to reduce a magnetic flux of at least one permanent magnet in one direction and increase a magnetic flux of at least one permanent magnet in another direction. The movable armature moves in the direction of the increased magnetic flux.

Abstract: A force sensing input device (such as a force sensing mouse) includes at least one force sensor and at least one top portion movably connected to at least one bottom portion. When a force is applied to the top portion, the top portion exerts pressure on the force sensor. The force sensor obtains force data based upon the pressure. The amount of force applied to the top portion, within a range of force amounts, is determined from at least the force data. In this way, a broader range of inputs may be receivable from the force sensing input device as compared to input devices that merely detect whether or not a button or similar element has been pushed.

Abstract: A two-layer cover with a compressible layer separating first and second layers. In some cases, capacitive sensing between the first and second layers can determine both touch locations and applied force.

Abstract: A force sensing input device (such as a force sensing mouse) includes at least one force sensor and at least one top portion movably connected to at least one bottom portion. When a force is applied to the top portion, the top portion exerts pressure on the force sensor. The force sensor obtains force data based upon the pressure. The amount of force applied to the top portion, within a range of force amounts, is determined from at least the force data. In this way, a broader range of inputs may be receivable from the force sensing input device as compared to input devices that merely detect whether or not a button or similar element has been pushed.