Abstract: Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Still further provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.

Abstract: A phosphate-free automatic dishwashing composition including an amine and an enzyme.

Abstract: An automatic dishwashing cleaning composition including a dispersant polymer and a surface-modification surface-substantive polymer.

Abstract: Described herein are methods for genetically modifying expanded hematopoietic cells comprising obtaining a quantity of hematopoietic cells, culturing the quantity of hematopoietic cells in the presence of at least one histone deacetylase inhibitor (HDACi) and at least one growth factor to expand the hematopoietic cells, and contacting the expanded hematopoietic cells with a nucleic acid sequence, wherein the nucleic acid sequence modifies the quantity of expanded hematopoietic cells. Further described herein are compositions comprising the genetically modified hematopoietic cells produced by these methods.

Abstract: An automatic dishwashing detergent composition having a pH as measured in 1% weight aqueous solution at 25° C. of from about 5 to about 7.5, the composition includes a sulfonated polymer.

Abstract: A phosphate-free automatic dishwashing composition including an amine and an enzyme.

Abstract: An automatic dishwashing detergent composition having a pH as measured in 1% weight aqueous solution at 25° C. of from about 5 to about 7.5, the composition includes a surface-modification surface-substantive polymer.

Abstract: An automatic dishwashing cleaning composition including a dispersant polymer and a surface-modification surface-substantive polymer wherein the composition leaves glass after being washed with the composition in an automatic dishwasher with a contact angle with deionised water of less than about 50° and wherein the surface-modification surface-substantive polymer has a rivulet forming effect on water drainage from glass.

Abstract: One embodiment is a uninterruptable power supply (UPS) system including a utility disconnect switch (UDS) coupled with an input line and an output line and structured to selectably connect and disconnect the input line and the output line. The UDS includes a semiconductor switching device connected between the input line and the output line, a surge arrester coupled in parallel with the semiconductor switching device, a dynamic voltage balancing device and a static voltage balancing device which are coupled in parallel with the semiconductor switching device.

Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.

Abstract: An automatic dishwashing cleaning composition having an alkyl amphocarboxylate surfactant.

Abstract: An automatic dishwashing cleaning composition including a dispersant polymer and a surface-modification surface-substantive polymer.

Abstract: An automatic dishwashing detergent composition having a pH as measured in 1% weight aqueous solution at 25° C. of from about 5 to about 7.5, the composition includes a sulfonated polymer.

Abstract: An automatic dishwashing detergent composition having a pH as measured in 1% weight aqueous solution at 25° C. of from about 5 to about 7.5, the composition includes a surface-modification surface-substantive polymer.

Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.

Abstract: An automatic dishwashing cleaning composition including a dispersant polymer and a surface-modification surface-substantive polymer wherein the composition leaves glass after being washed with the composition in an automatic dishwasher with a contact angle with deionised water of less than about 50° and wherein the surface-modification surface-substantive polymer has a rivulet forming effect on water drainage from glass.

Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.

Abstract: Described herein are methods and compositions which lead to the efficient ex vivo expansion of hematopoietic cells, such as hematopoietic stem cells (HSCs) and hematopoietic stem and progenitor cells HSPCs. Using combinations of small molecule drugs and cytokines/growth factors/grown factors targeting epigenetic status in cells, significant improvements in the expansion of cells was observed, including cells isolated from human cord blood or peripheral mobilized stem/progenitor cells. Multiple genes implicated in HSPC function were unperturbed, and efficiency of genomic editing using lentivirus was greatly enhanced following treatment. These novel approaches could be used therapeutically in a variety of hematopoietic transplantation settings, in addition to benefiting gene therapy techniques.

Abstract: One embodiment is a uninterruptable power supply (UPS) system including a utility disconnect switch (UDS) coupled with an input line and an output line and structured to selectably connect and disconnect the input line and the output line. The UDS includes a semiconductor switching device connected between the input line and the output line, a surge arrester coupled in parallel with the semiconductor switching device, a dynamic voltage balancing device and a static voltage balancing device which are coupled in parallel with the semiconductor switching device.