Patents by Inventor James Elliott Bradner

James Elliott Bradner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating leukemia
    Patent number: 10676484
    Abstract: The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: June 9, 2020
    Assignees: Dana-Farber Cancer Institute, Inc., Cold Spring Harbor Institute
    Inventors: James Elliott Bradner, Johannes Zuber, Junwei Shi, Christopher R. Vakoc, Scott W. Lowe, Constantine S. Mitsiades
  • COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS
    Publication number: 20200148702
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Application
    Filed: July 19, 2019
    Publication date: May 14, 2020
    Inventors: James Elliott Bradner, Jun Qi
  • Compositions and methods for treating neoplasia, inflammatory disease and other disorders
    Patent number: 10407441
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: September 10, 2019
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: James Elliott Bradner, Jun Qi
  • COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS
    Publication number: 20180237454
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Application
    Filed: February 1, 2018
    Publication date: August 23, 2018
    Inventors: James Elliott Bradner, Jun Qi
  • COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA
    Publication number: 20180222917
    Abstract: The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
    Type: Application
    Filed: October 17, 2017
    Publication date: August 9, 2018
    Inventors: James Elliott Bradner, Johannes Zuber, Junwei Shi, Christopher R. Vakoc, Scott W. Lowe, Constantine S. Mitsiades
  • Compositions and methods for treating leukemia
    Patent number: 9815849
    Abstract: The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 14, 2017
    Assignees: Dana-Farber Cancer Institute, Inc., Cold Spring Harbor Laboratory
    Inventors: James Elliott Bradner, Johannes Zuber, Junwei Shi, Christopher R. Vakoc, Scott W. Lowe, Constantine S. Mitsiades
  • Male contraceptive compositions and methods of use
    Patent number: 9789120
    Abstract: The invention relates to compositions and methods for effecting male contraception.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: October 17, 2017
    Assignees: Dana-Farber Cancer Institute, Inc., Baylor College of Medicine
    Inventors: James Elliott Bradner, Martin Matzuk, Jun Qi
  • Compositions and Methods for Treating Neoplasia, Inflammatory Disease and Other Disorders
    Publication number: 20170029437
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Application
    Filed: March 4, 2016
    Publication date: February 2, 2017
    Inventors: James Elliott Bradner, Jun Qi
  • LNA antisense oligonucleotides for the modulation of Myc expression
    Patent number: 9506060
    Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: November 29, 2016
    Assignees: DANA-FARBER CANCER INSTITUTE, INC., ENZON PHARMACEUTICALS, INC.
    Inventors: Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
  • Male Contraceptive Compositions And Methods Of Use
    Publication number: 20160317547
    Abstract: The invention relates to compositions and methods for effecting male contraception.
    Type: Application
    Filed: December 21, 2015
    Publication date: November 3, 2016
    Inventors: James Elliott Bradner, Martin Matzuk, Jun Qi
  • Compositions and methods for treating neoplasia, inflammatory disease and other disorders
    Patent number: 9320741
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: April 26, 2016
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: James Elliott Bradner, Jun Qi
  • Male contraceptive compositions and methods of use
    Patent number: 9301962
    Abstract: The invention relates to compositions and methods for effecting male contraception.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: April 5, 2016
    Assignees: Baylor College of Medicine, Dana Farber Cancer Institute, Inc.
    Inventors: James Elliott Bradner, Martin Matzuk, Jun Qi
  • LNA ANTISENSE OLIGONUCLEOTIDES FOR THE MODULATION OF MYC EXPRESSION
    Publication number: 20160024495
    Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 28, 2016
    Inventors: Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
  • Compositions and Methods for Treating Neoplasia, Inflammatory Disease and Other Disorders
    Publication number: 20150150885
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Application
    Filed: September 30, 2014
    Publication date: June 4, 2015
    Inventors: James Elliott Bradner, Jun Qi
  • Compositions and methods for treating neoplasia, inflammatory disease and other disorders
    Patent number: 8981083
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: March 17, 2015
    Assignee: Dana Farber Cancer Institute, Inc.
    Inventors: James Elliott Bradner, Jun Qi
  • Compositions and Methods for Treating Leukemia
    Publication number: 20140011862
    Abstract: The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Applicants: Cold Spring Harbor Laboratory, Dana-Farber Cancer Institute, Inc.
    Inventors: James Elliott Bradner, Johannes Zuber, Junwei Shi, Christopher R. Vakoc
  • COMPOSITIONS AND METHODS FOR MODULATING METABOLISM
    Publication number: 20130252331
    Abstract: The invention provides compositions comprising an effective amount of an agent that inhibits a BET protein (e.g., Brd2, Brd3, Brd4), and methods of using such compositions for treating or preventing metabolic syndrome, obesity, type II diabetes, insulin resistance, and related disorders characterized by undesirable alterations in metabolism or fat accumulation.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 26, 2013
    Inventors: James Elliott Bradner, Jonathan Brown, Jorge Plutzky
  • Male Contraceptive Compositions and Methods of Use
    Publication number: 20130210813
    Abstract: The invention relates to compositions and methods for effecting male contraception.
    Type: Application
    Filed: May 16, 2011
    Publication date: August 15, 2013
    Inventors: James Elliott Bradner, Martin Matzuk, Jun Qi
  • Compositions And Methods For Treating Neoplasia, Inflammatory Disease And Other Disorders
    Publication number: 20130184264
    Abstract: The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
    Type: Application
    Filed: May 16, 2011
    Publication date: July 18, 2013
    Inventors: James Elliott Bradner, Jun Qi